Combined Thrombophilic Mutations in Women with Unexplained Recurrent Miscarriage

To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group.

[1]  P. Langhorne,et al.  Thrombophilia in pregnancy: a systematic review , 2006, British journal of haematology.

[2]  C. Coulam,et al.  Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage. , 2004, American journal of reproductive immunology.

[3]  F. Sánchez-Jiménez,et al.  An in vitro evaluation of the effects of homocysteine thiolactone on key steps of angiogenesis and tumor invasion. , 2003, Biochemical and biophysical research communications.

[4]  C. Oberkanins,et al.  Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss. , 2003, Clinical chemistry.

[5]  G. Heinze,et al.  Combined thrombophilic polymorphisms in women with idiopathic recurrent miscarriage. , 2003, Fertility and sterility.

[6]  S. Kahn,et al.  Thrombophilic disorders and fetal loss: a meta-analysis , 2003, The Lancet.

[7]  G. Vartholomatos,et al.  Prevalence of the G20210A prothrombin gene mutation in Northwestern Greece and association with venous thromboembolism. , 2003, International angiology : a journal of the International Union of Angiology.

[8]  S. Schellong,et al.  Coagulation factor V G allele and HR2 haplotype: factor V activity, activated protein C resistance and risk of venous thrombosis , 2003, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[9]  G. Vartholomatos,et al.  Lack of association between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene and venous thromboembolism in Northwestern Greece. , 2002, International angiology : a journal of the International Union of Angiology.

[10]  F. Sánchez-Jiménez,et al.  Anti-angiogenic effects of homocysteine on cultured endothelial cells. , 2002, Biochemical and biophysical research communications.

[11]  N. Sebire,et al.  Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. , 2002, Human reproduction.

[12]  K. Blennow,et al.  Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos , 2002, European Journal of Human Genetics.

[13]  W. Hooper,et al.  Factor V Leiden and Factor V R2 Allele: High-throughput Analysis and Association with Venous Thromboembolism , 2001, Thrombosis and Haemostasis.

[14]  T. Kohlmann,et al.  Selection pressure for the factor-V-Leiden mutation and embryo implantation , 2001, The Lancet.

[15]  C. P. Morris,et al.  The factor V HR2 haplotype: prevalence and association of the A4070G and A6755G polymorphisms , 2001, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[16]  G. Vartholomatos,et al.  The prevalence of factor V Leiden as a risk factor for venous thromboembolism in the population of North-Western Greece. , 2000, International angiology : a journal of the International Union of Angiology.

[17]  F. Rosendaal,et al.  The HR2 Haplotype of Factor V Is not Associated with the Risk of Myocardial Infarction , 2000, Thrombosis and Haemostasis.

[18]  E. Yilmaz,et al.  Factor V (His 1299 Arg) in Young Turkish Patients with Cerebral Infarct , 2000, Pathophysiology of Haemostasis and Thrombosis.

[19]  T. Agorastos,et al.  Factor V leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages. , 2000, Human reproduction.

[20]  E. Gabazza,et al.  The zymogen prothrombin stimulates cell locomotion and calcium influx in murine osteosarcoma cells by different mechanism from thrombin. , 1999, International journal of oncology.

[21]  C. Conlon,et al.  A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. , 1999, Human reproduction.

[22]  R. Matalon,et al.  Methylenetetrahydrofolate reductase (MTHFR): the incidence of mutations C677T and A1298C in the Ashkenazi Jewish population. , 1999, American journal of medical genetics.

[23]  Y. Friedlander,et al.  A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. , 1999, The Journal of nutrition.

[24]  E. Oger,et al.  Hormone Replacement Therapy and Circulating ICAM-1 in Postmenopausal Women , 1999, Thrombosis and Haemostasis.

[25]  V. Nicaud,et al.  The Factor V Gene A4070G Mutation and the Risk of Venous Thrombosis , 1999, Thrombosis and Haemostasis.

[26]  B. Pentecost,et al.  Role of thrombin receptor in breast cancer invasiveness , 1999, British Journal of Cancer.

[27]  R. Rozen,et al.  A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. , 1998, Molecular genetics and metabolism.

[28]  P. Reitsma,et al.  A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. , 1996, Blood.

[29]  F. Rosendaal,et al.  Increased fetal loss in women with heritable thrombophilia , 1996, The Lancet.

[30]  B. Dahlbäck,et al.  Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. , 1994, The Journal of clinical investigation.

[31]  G. Hardy MENDELIAN PROPORTIONS IN A MIXED POPULATION. , 1908 .

[32]  E. Jauniaux,et al.  Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. , 2003, The American journal of pathology.

[33]  C. Oberkanins,et al.  Plasminogen Activator Inhibitor 1 4 G / 5 G Polymorphism and Coagulation Factor XIII Val 34 Leu Polymorphism : Impaired Fibrinolysis and Early Pregnancy Loss , 2003 .

[34]  D. Girelli,et al.  Functional Properties of Factor V and Factor Va Encoded by the R2-gene , 2001, Thrombosis and Haemostasis.

[35]  R. Matthews,et al.  A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase , 1995, Nature Genetics.