Effect of subchronic administration of agomelatine on brain energy metabolism and oxidative stress parameters in rats

The aim of this study was to investigate the effect of subchronic administration of agomelatine on energy metabolism, oxidative stress markers and antioxidant defense in the brains of rats.

[1]  A. C. Uguz,et al.  Agomelatine and Duloxetine Synergistically Modulates Apoptotic Pathway by Inhibiting Oxidative Stress Triggered Intracellular Calcium Entry in Neuronal PC12 Cells: Role of TRPM2 and Voltage-Gated Calcium Channels , 2014, The Journal of Membrane Biology.

[2]  Q. Ma.  Advances in mechanisms of anti-oxidation. , 2014, Discovery medicine.

[3]  J. O'Donnell,et al.  Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment , 2014, Current neuropharmacology.

[4]  M. Pompili,et al.  Agomelatine, a novel intriguing antidepressant option enhancing neuroplasticity: A critical review , 2013, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[5]  R. Salomon,et al.  Increased oxidative stress in patients with depression and its relationship to treatment , 2013, Psychiatry Research.

[6]  J. Thome,et al.  The role of oxidative stress in depressive disorders. , 2012, Current pharmaceutical design.

[7]  A. Brzezinski,et al.  Role of melatonin in mood disorders and the antidepressant effects of agomelatine , 2012, Expert opinion on investigational drugs.

[8]  J. Quevedo,et al.  Differential effects of escitalopram administration on metabolic parameters of cortical and subcortical brain regions of Wistar rats , 2012, Acta Neuropsychiatrica.

[9]  B. Frey,et al.  Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder , 2012, Oxidative medicine and cellular longevity.

[10]  J. Quevedo,et al.  Brain energy metabolism is increased by chronic administration of bupropion , 2012, Acta Neuropsychiatrica.

[11]  Omer Kalayci,et al.  Oxidative Stress and Antioxidant Defense , 2012, The World Allergy Organization journal.

[12]  C. Gabriel,et al.  Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression , 2011, Pharmacology Biochemistry and Behavior.

[13]  Basel A. Abdel-Wahab,et al.  Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice , 2011, Pharmacology Biochemistry and Behavior.

[14]  J. Quevedo,et al.  Activity of mitochondrial respiratory chain is increased by chronic administration of antidepressants , 2011, Acta Neuropsychiatrica.

[15]  Z. Fišar,et al.  Connectivity between mitochondrial functions and psychiatric disorders , 2011, Psychiatry and clinical neurosciences.

[16]  G. Réus,et al.  Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus , 2010, Oxidative medicine and cellular longevity.

[17]  F. Scaglia.  The role of mitochondrial dysfunction in psychiatric disease. , 2010, Developmental disabilities research reviews.

[18]  G. Réus,et al.  Effects of olanzapine, fluoxetine and olanzapine/fluoxetine on creatine kinase activity in rat brain , 2009, Brain Research Bulletin.

[19]  J. Quevedo,et al.  Brain creatine kinase activity is increased by chronic administration of paroxetine , 2009, Brain Research Bulletin.

[20]  B. Cumurcu,et al.  Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment , 2009, Psychiatry and clinical neurosciences.

[21]  J. Quevedo,et al.  Effect of acute administration of ketamine and imipramine on creatine kinase activity in the brain of rats. , 2009, Revista brasileira de psiquiatria.

[22]  G. Réus,et al.  Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm. , 2009, Journal of psychiatric research.

[23]  J. Quevedo,et al.  Mitochondrial Dysfunction and Psychiatric Disorders , 2009, Neurochemical Research.

[24]  G. Réus,et al.  Effects of chronic mild stress on the oxidative parameters in the rat brain , 2009, Neurochemistry International.

[25]  J. Quevedo,et al.  Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression , 2008, Neurochemistry International.

[26]  L. T. Kubota,et al.  Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação , 2007 .

[27]  A. Navarro,et al.  The mitochondrial energy transduction system and the aging process. , 2007, American journal of physiology. Cell physiology.

[28]  S. Selek,et al.  Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment. , 2007, Archives of medical research.

[29]  Hans-Peter Braun,et al.  Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System* , 2007, Journal of Biological Chemistry.

[30]  J. V. Bannister,et al.  Assays for superoxide dismutase. , 2006, Methods of biochemical analysis.

[31]  Barry Halliwell,et al.  Oxidative stress and neurodegeneration: where are we now? , 2006, Journal of neurochemistry.

[32]  Vera Adam-Vizi,et al.  Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. , 2005, Antioxidants & redox signaling.

[33]  N. Kolla,et al.  Amitriptyline and fluoxetine protect PC12 cells from cell death induced by hydrogen peroxide. , 2005, Journal of psychiatry & neuroscience : JPN.

[34]  Yau-Huei Wei,et al.  Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress. , 2005, The international journal of biochemistry & cell biology.

[35]  M. Papp,et al.  Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat , 2003, Neuropsychopharmacology.

[36]  Peter Herscovitch,et al.  Regional cerebral glucose utilization in patients with a range of severities of unipolar depression , 2002, Biological Psychiatry.

[37]  J. Leza,et al.  Glutathione Depletion, Lipid Peroxidation and Mitochondrial Dysfunction Are Induced by Chronic Stress in Rat Brain , 2001, Neuropsychopharmacology.

[38]  R. Radi,et al.  Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. , 1996, Archives of biochemistry and biophysics.

[39]  T. Bourgeron,et al.  Biochemical and molecular investigations in respiratory chain deficiencies. , 1994, Clinica chimica acta; international journal of clinical chemistry.

[40]  J. Berden,et al.  Differential investigation of the capacity of succinate oxidation in human skeletal muscle. , 1985, Clinica chimica acta; international journal of clinical chemistry.

[41]  B. P. Hughes.  A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera. , 1962, Clinica chimica acta; international journal of clinical chemistry.

[42]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[43]  Z. Fišar,et al.  Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers. , 2010, Neuro endocrinology letters.

[44]  E. Stadtman,et al.  Carbonyl assays for determination of oxidatively modified proteins. , 1994, Methods in enzymology.

[45]  H. H. Draper,et al.  Malondialdehyde determination as index of lipid peroxidation. , 1990, Methods in enzymology.

[46]  H. Aebi,et al.  Catalase in vitro. , 1984, Methods in enzymology.