Histology of the lacrimal gland in keratoconjunctivitis sicca.

The histology of Sjogren's syndrome, which is defined as keratoconjunctivitis sicca (KCS) with xerostomia and rheumatoid arthritis, for the purpose of this communication, has been studied post mortem either in single cases or in series of not more than three patients (Sjogren, I933; Holm, I949; Allington, I950; Bohm, I950; Ellman, Weber, and Goodier, I95I; Morgan and Raven, 1952; Cardell and Gurling, I954; Szanto, Farkas, and Gyulai 1957; Funatsu and Eguchi, I957; Bucher and Reid, 1959; Bain, I960; Bloch, Buchanan, Wohl, and Bunim, I965). The lacrimal and salivary glands, and the mucous glands of the respiratory tract, mouth, and upper oesophagus are typically involved. However, most of the observa-tions on lacrimal gland structure were recorded in severe cases of KCS and in patients who had died as a result of the severe complications of arthritis or another connective tissue disease. The primary purpose of this study was to investigate the histology of the lacrimal gland in patients currently suffering from KCS. sedimentation and duct were and x-ray and the that the had mild chronic rheumatoid when the biopsy was