论文信息 - Cardiac Dysrhythmia Following Reversal of Neuromuscular Blocking Agents in Geriatric Patients

Cardiac Dysrhythmia Following Reversal of Neuromuscular Blocking Agents in Geriatric Patients

Ninety-three patients 65 years of age or older were studied to determine the incidence of dysrhythmia following administration of 1 of 2 cholinesterase inhibitors, neostigmine or pyridostigmine. The ECG was then continuously monitored for 90 minutes. Neostigmine was associated with a higher incidence of dysrhythmia than was pyridostigmine. Neostigmine administered to patients with pre-existing coronary artery disease and/or conduction defects and to patients with hypertension was associated with a significantly higher incidence of dysrhythmia than was pyridostigmine when administered to patients with the same conditions.The incidence of dysrhythmia in patients who received a halogenated anesthetic was 5 times greater after neostigmine than after pyridostigmine.

C. R. Stephen | W. Owens | L. Waldbaum

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