Contrast enhancement of spectral domain optical coherence tomography using spectrum correction

In this paper, we propose spectrum correction method to enhance image contrast of spectral domain optical coherence tomography (SD-OCT). The proposed method firstly reshapes the light source to a Hann-shape spectral light by digital processing and then strengthens the coherence numerical value in the main lobe of the axial point spread function(PSF). Experimental results acquired from fresh rat corneas and fixed human aortic atherosclerosis tissues show that the proposed method improves image definition and clarity, and consequently provides better detailed microstructural information than the existing method. This ability of improving image quality is obtained without any hardware change, making our method a cost-effective alternative to competing with hardware approaches.

[1]  J. Schuman,et al.  Optical coherence tomography. , 2000, Science.

[2]  P. Duraisamy,et al.  Visual contrast enhancement of optical coherence tomography images by combined and image fusion methods , 2010, 2010 Second International conference on Computing, Communication and Networking Technologies.

[3]  Ping Shum,et al.  Dual spectrometer system with spectral compounding for 1-μm optical coherence tomography in vivo. , 2014, Optics letters.

[4]  K. Suslick,et al.  Engineered microsphere contrast agents for optical coherence tomography. , 2003, Optics letters.

[5]  J. Fujimoto,et al.  Three-dimensional endomicroscopy using optical coherence tomography , 2007 .

[6]  M Yu Kirillin,et al.  Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation , 2008, Physics in medicine and biology.

[7]  C Ross Ethier,et al.  Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head. , 2011, Investigative ophthalmology & visual science.

[8]  Linbo Liu,et al.  High-resolution extended source optical coherence tomography. , 2015, Optics express.

[9]  Ding Kang,et al.  CORRECTIONS FOR FREQUENCY, AMPLITUDE AND PHASE IN A FAST FOURIER TRANSFORM OF A HARMONIC SIGNAL , 1996 .

[10]  Guoguang Mu,et al.  Contrast enhancement of optical coherence tomography images using least squares fitting and histogram matching , 2007 .

[11]  Ping Shum,et al.  Micro-optical coherence tomography (μOCT) in vivo , 2014 .

[12]  Y. Yagi,et al.  Imaging the Subcellular Structure of Human Coronary Atherosclerosis Using 1-μm Resolution Optical Coherence Tomography (μOCT) , 2011, Nature Medicine.

[13]  Linbo Liu,et al.  Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography , 2014, PloS one.

[14]  Hossein Rabbani,et al.  Statistical Modeling of Retinal Optical Coherence Tomography , 2016, IEEE Transactions on Medical Imaging.

[15]  J. Mari,et al.  Enhancement of lamina cribrosa visibility in optical coherence tomography images using adaptive compensation. , 2013, Investigative Ophthalmology and Visual Science.

[16]  Masanori Hangai,et al.  Spectral-domain optical coherence tomography with multiple B-scan averaging for enhanced imaging of retinal diseases. , 2008, Ophthalmology.

[17]  P. A. Gorry.  General least-squares smoothing and differentiation by the convolution (Savitzky-Golay) method , 1990 .

[18]  J. L. Pichardo-Molina,et al.  Contrast enhancement of optical coherence tomography images using branched gold nanoparticles , 2012 .

[19]  Angelika Unterhuber,et al.  Optical coherence tomography today: speed, contrast, and multimodality , 2014, Journal of biomedical optics.

[20]  N. Zhang,et al.  Dielectric-Grating-Coupled Surface Plasmon Resonance From the Back Side of the Metal Film for Ultrasensitive Sensing , 2016, IEEE Photonics Journal.

[21]  James Fujimoto,et al.  Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation. , 2004, Optics express.

[22]  Renu Tripathi,et al.  Spectral shaping for non-Gaussian source spectra in optical coherence tomography. , 2002, Optics letters.

[23]  Eva Lankenau,et al.  OCT in Dermatology , 2008 .

[24]  J. Fujimoto.  Optical coherence tomography for ultrahigh resolution in vivo imaging , 2003, Nature Biotechnology.

[25]  K. Chu,et al.  Method for Quantitative Study of Airway Functional Microanatomy Using Micro-Optical Coherence Tomography , 2013, PloS one.

[26]  Malini Olivo,et al.  Control of optical contrast using gold nanoshells for optical coherence tomography imaging of mouse xenograft tumor model in vivo. , 2009, Journal of biomedical optics.

[27]  Jennifer K Barton,et al.  Optical coherence tomography with plasmon resonant nanorods of gold. , 2007, Optics letters.

[28]  Geoff Wyvill,et al.  Smoothing of three dimensional models by convolution , 1996, Proceedings of CG International '96.

[29]  J. Duker,et al.  Optical coherence tomography – current and future applications , 2013, Current Opinion in Ophthalmology.

[30]  J. Gardecki,et al.  An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load. , 2014, American journal of respiratory cell and molecular biology.

[31]  Linbo Liu,et al.  Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography , 2016, IEEE Photonics Journal.