Comment on “Histomorphological Factors Predicting the Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer”

http://ejbc.kr | pISSN 1738-6756 eISSN 2092-9900 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. To the Editor, I read the article by Jung et al. [1] regarding histomorphological factors predicting the response to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer. They concluded that independent predictors of pathologic complete response after NAC were a higher number of tumor-infiltrating lymphocytes (p = 0.007), absence of clear cytoplasm (p = 0.008), low levels of tumor necrosis (p= 0.018), and high histologic grade (p= 0.039). However, the authors did not include lymphovascular invasion as a histomorphological factor in univariate and multivariate analyses. Another study tested pathologic complete response to NAC in 324 patients with primary nonmetastatic breast cancer. In this study, multivariable regression analysis identified lymphovascular invasion (odds ratio, 0.05; 95% confidence interval, 0.01–0.18; p = 0.0000) as a predictive impact in patients with breast cancer receiving NAC [2]. In conclusion, lymphovascular invasion should be evaluated as a predictive factor for patients receiving NAC for triple-negative breast cancer.