Long Fiber Formation of Hydroxyapatite/Collagen Nanocomposites through a Self-Organization Mechanism

Abstract : Long fibers of bone-like hydroxyapatite/collagen nanocomposites were fabricated via a self-organization under biomimetic conditions to obtain much more suitable biomechanical and biochemical properties for artificial bone and tissue engineering scaffolds. The fiber growth was controlled with ionic strength in the reaction vessel and was explained by a crystal growth model. The composite fiber grew up to 75 mm in length and demonstrated straight extinction under a polarized microscope. The composite compacts were incorporated into bone metabolism, and their resorption was controlled with cross linkage. The composite is utilizable for the bone reconstruction materials that can gradually change into bone.

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