论文信息 - Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil

Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil

MonolixSuite is a software widely used for model‐based drug development. It contains interconnected applications for data visualization, noncompartmental analysis, nonlinear mixed effect modeling, and clinical trial simulations. Its main assets are ease of use via an interactive graphical interface, computation speed, and efficient parameter estimation even for complex models. This tutorial presents a step‐by‐step pharmacokinetic (PK) modeling workflow using MonolixSuite, including how to visualize the data, set up a population PK model, estimate parameters, and diagnose and improve the model incrementally.

[1] S L Shafer,et al. Influence of Age and Gender on the Pharmacokinetics and Pharmacodynamics of Remifentanil: I. Model Development , 1997, Anesthesiology.

[2] Marc Lavielle,et al. Automatic data binning for improved visual diagnosis of pharmacometric models , 2011, Journal of Pharmacokinetics and Pharmacodynamics.

[3] Marc Lavielle,et al. Enhanced Method for Diagnosing Pharmacometric Models: Random Sampling from Conditional Distributions , 2016, Pharmaceutical Research.

[4] Marc Lavielle,et al. Maximum likelihood estimation in nonlinear mixed effects models , 2005, Comput. Stat. Data Anal..

[5] Andrew C. Hooker,et al. Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models , 2011, The AAPS Journal.

[6] D R Mould,et al. Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development—Part 2: Introduction to Pharmacokinetic Modeling Methods , 2013, CPT: pharmacometrics & systems pharmacology.

[7] France Mentré,et al. Extension of the SAEM algorithm to left-censored data in nonlinear mixed-effects model: Application to HIV dynamics model , 2006, Comput. Stat. Data Anal..

[8] Maud Delattre,et al. A note on BIC in mixed-effects models , 2014 .

[9] D R Mould,et al. Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development , 2012, CPT: pharmacometrics & systems pharmacology.