Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

Previous studies have shown that the orbital and medial prefrontal cortex (OMPFC) is extensively connected with medial temporal and cingulate limbic structures. In this study, the organization of these projections was defined in relation to architectonic areas within the OMPFC. All of the limbic structures were substantially connected with the following posterior and medial orbital areas: the posteromedial, medial, intermediate, and lateral agranular insular areas (Iapm, Iam, Iai, and Ial, respectively) and areas 11m, 13a, 13b, 14c, and 14r. In contrast, lateral orbital areas 12o, 12m, and [12] and medial wall areas 24a, b and 32 were primarily connected with the amygdala, the temporal pole, and the cingulate cortex. Data were not obtained on the poateroventral medial wall.

[1]  D. Amaral,et al.  The entorhinal cortex of the monkey: II. Cortical afferents , 1987, The Journal of comparative neurology.

[2]  E. T. Rolls,et al.  Effects of satiety on self-stimulation of the orbitofrontal cortex in the rhesus monkey , 1979, Neuroscience Letters.

[3]  H. Klüver,et al.  PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS , 1939 .

[4]  D. Amaral,et al.  An autoradiographic study of the projections of the central nucleus of the monkey amygdala , 1981, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[5]  P. Goldman-Rakic,et al.  Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey , 1984, Neuroscience.

[6]  Mortimer Mishkin,et al.  Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys , 1986, Behavioural Brain Research.

[7]  R. E. Passingham,et al.  Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta) , 1980, Brain Research.

[8]  J. Price,et al.  Central olfactory connections in the macaque monkey , 1994, The Journal of comparative neurology.

[9]  J. W. Papez.  A PROPOSED MECHANISM OF EMOTION , 1937 .

[10]  H. Barbas,et al.  Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey , 1990, The Journal of comparative neurology.

[11]  D. R. Snyder,et al.  Effects of orbital frontal lesions on aversive and aggressive behaviors in rhesus monkeys. , 1970, Journal of comparative and physiological psychology.

[12]  Joseph E LeDoux,et al.  The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[13]  Douglas L. Rosene,et al.  The Hippocampal Formation of the Primate Brain , 1987 .

[14]  M. Witter.  A survey of the anatomy of the hippocampal formation, with emphasis on the septotemporal organization of its intrinsic and extrinsic connections. , 1986, Advances in experimental medicine and biology.

[15]  M. Inase,et al.  Two movement-related foci in the primate cingulate cortex observed in signal-triggered and self-paced forelimb movements. , 1991, Journal of neurophysiology.

[16]  David Gaffan,et al.  Amygdala and the memory of reward. , 1992 .

[17]  A. Kling.  Effects of amygdalectomy and testosterone on sexual behavior of male juvenile macaques. , 1968, Journal of comparative and physiological psychology.

[18]  L. Heimer,et al.  New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata , 1988, Neuroscience.

[19]  G. V. Van Hoesen,et al.  Cingulate input to the primary and supplementary motor cortices in the rhesus monkey: Evidence for somatotopy in areas 24c and 23c , 1992, The Journal of comparative neurology.

[20]  RP Dum,et al.  The origin of corticospinal projections from the premotor areas in the frontal lobe , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[21]  M Mishkin,et al.  The origin, course, and termination of the hippocampothalamic projections in the macaque , 1986, The Journal of comparative neurology.

[22]  H Nishijo,et al.  Single neuron responses in amygdala of alert monkey during complex sensory stimulation with affective significance , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  W. Nauta,et al.  A note on the problem of olfactory associations of the orbitofrontal cortex in the monkey , 1979, Neuroscience.

[24]  S. Carmichael,et al.  Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys , 1996 .

[25]  D L Rosene,et al.  A comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: I. Convergence in the entorhinal, prorhinal, and perirhinal cortices , 1988, The Journal of comparative neurology.

[26]  Paul D. MacLean,et al.  Vagal elicitation of respiratory-type and other unit responses in basal limbic structures of squirrel monkeys , 1981, Brain Research.

[27]  M P Witter,et al.  The subiculum: cytoarchitectonically a simple structure, but hodologically complex. , 1990, Progress in brain research.

[28]  T. Kaneko,et al.  Thalamocortical and thalamo‐amygdaloid projections from the parvicellular division of the posteromedial ventral nucleus in the cat , 1987, The Journal of comparative neurology.

[29]  D. Amaral,et al.  The afferent input to the magnocellular division of the mediodorsal thalamic nucleus in the monkey, Macaca fascicularis , 1987, The Journal of comparative neurology.

[30]  N. Geschwind.  Disconnexion syndromes in animals and man. I. , 1965, Brain : a journal of neurology.

[31]  E T Rolls,et al.  Information processing in the taste system of primates. , 1989, The Journal of experimental biology.

[32]  E. Rolls,et al.  An electrophysiological and behavioural study of self-stimulation in the orbitofrontal cortex of the rhesus monkey , 1980, Brain Research Bulletin.

[33]  M. W. Brown,et al.  Hippocampus and medial temporal cortex: Neuronal activity related to behavioural responses during the performance of memory tasks by primates , 1990, Behavioural Brain Research.

[34]  B. Vogt,et al.  Connections of the Monkey Cingulate Cortex , 1993 .

[35]  Brent A. Vogt,et al.  Structural Organization of Cingulate Cortex: Areas, Neurons, and Somatodendritic Transmitter Receptors , 1993 .

[36]  C. Rosenkilde,et al.  Functional heterogeneity of the prefrontal cortex in the monkey: a review. , 1979, Behavioral and neural biology.

[37]  J. Price,et al.  Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys , 1995, The Journal of comparative neurology.

[38]  M. Voytko.  Cooling orbital frontal cortex disrupts matching-to-sample and visual discrimination learning in monkeys , 1985 .

[39]  H. Weingartner,et al.  The effects of lateralized frontal lesions on mood regulation. , 1986, Brain : a journal of neurology.

[40]  D. Amaral,et al.  Amygdalo‐cortical projections in the monkey (Macaca fascicularis) , 1984, The Journal of comparative neurology.

[41]  D. N. Pandya,et al.  Insular interconnections with the amygdala in the rhesus monkey , 1981, Neuroscience.

[42]  Arthur P. Shimamura,et al.  Source memory impairment in patients with frontal lobe lesions , 1989, Neuropsychologia.

[43]  D. Amaral,et al.  Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex , 1991, The Journal of comparative neurology.

[44]  J. Tigges,et al.  Subcortical structures projecting to visual cortical areas in squirrel monkey , 1982, The Journal of comparative neurology.

[45]  D. Amaral,et al.  The entorhinal cortex of the monkey: I. Cytoarchitectonic organization , 1987, The Journal of comparative neurology.

[46]  J. Price,et al.  Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey , 1994, The Journal of comparative neurology.

[47]  D. Amaral,et al.  Topographical organization of the entorhinal projection to the dentate gyrus of the monkey , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[48]  J. Price,et al.  The distribution of choline acetyltransferase in the rat amygdaloid complex and adjacent cortical areas, as determined by quantitative micro‐assay and immunohistochemistry , 1986, The Journal of comparative neurology.

[49]  H. Ursin,et al.  Food preference in brain lesioned monkeys , 1969 .

[50]  A. Hendrickson,et al.  The autoradiographic demonstration of axonal connections in the central nervous system. , 1972, Brain research.

[51]  G. V. Van Hoesen,et al.  Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey. , 1977, Science.

[52]  D L Rosene,et al.  Cingulate cortex of the rhesus monkey: I. Cytoarchitecture and thalamic afferents , 1987, The Journal of comparative neurology.

[53]  P. Goldman-Rakic,et al.  The primate mediodorsal (MD) nucleus and its projection to the frontal lobe , 1985, The Journal of comparative neurology.

[54]  A. Gade,et al.  Amnesia after operations on aneurysms of the anterior communicating artery. , 1982, Surgical neurology.

[55]  M. Mesulam,et al.  Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain , 1982, The Journal of comparative neurology.

[56]  W. Nauta,et al.  Neural associations of the amygdaloid complex in the monkey. , 1962, Brain : a journal of neurology.

[57]  J. Price,et al.  The organization of projections from the mediodorsal nucleus of the thalamus to orbital and medial prefrontal cortex in macaque monkeys , 1993, The Journal of comparative neurology.

[58]  H. Niki,et al.  Hippocampal unit activity and delayed response in the monkey , 1985, Brain Research.

[59]  Deepak N. Pandya,et al.  Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents , 1975, Brain Research.

[60]  D. J. Felleman,et al.  Distributed hierarchical processing in the primate cerebral cortex. , 1991, Cerebral cortex.

[61]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[62]  E. Drewe,et al.  The effect of type and area of brain lesion on Wisconsin card sorting test performance. , 1974, Cortex; a journal devoted to the study of the nervous system and behavior.

[63]  R. Passingham,et al.  Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta). , 1981, Journal of comparative and physiological psychology.

[64]  P. Goldman-Rakic,et al.  Direct and indirect pathways from the amygdala to the frontal lobe in rhesus monkeys , 1981, The Journal of comparative neurology.

[65]  I. Riches,et al.  The effects of visual stimulation and memory on neurons of the hippocampal formation and the neighboring parahippocampal gyrus and inferior temporal cortex of the primate , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[66]  P. Maclean,et al.  Contrasting functions of limbic and neocortical systems of the brain and their relevance to psychophysiological aspects of medicine. , 1958, The American journal of medicine.

[67]  E. Drewe.  Go - No Go Learning After Frontal Lobe Lesions in Humans , 1975, Cortex.

[68]  ET Rolls,et al.  Learning and memory is reflected in the responses of reinforcement- related neurons in the primate basal forebrain , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[69]  H. Barbas,et al.  Contralateral thalamic projections predominantly reach transitional cortices in the rhesus monkey , 1994, The Journal of comparative neurology.

[70]  T. Jay,et al.  Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris‐leucoagglutinin , 1991, The Journal of comparative neurology.

[71]  D. Weinberger,et al.  Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. , 1992, The American journal of psychiatry.

[72]  H. Barbas,et al.  Diverse thalamic projections to the prefrontal cortex in the rhesus monkey , 1991, The Journal of comparative neurology.

[73]  B. Pillon,et al.  Human autonomy and the frontal lobes. Part I: Imitation and utilization behavior: A neuropsychological study of 75 patients , 1986, Annals of neurology.

[74]  D L Rosene,et al.  Comparison of the efferents of the amygdala and the hippocampal formation in the rhesus monkey: II. Reciprocal and non‐reciprocal connections , 1988, The Journal of comparative neurology.

[75]  A. Mikami,et al.  Activity of single neurons in the monkey amygdala during performance of a visual discrimination task. , 1992, Journal of neurophysiology.

[76]  Rylande r.  PERSONALITY CHANGES AFTER OPERATIONS ON THE FRONTAL LOBES , 1943 .

[77]  David P. Friedman,et al.  Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touch , 1986, The Journal of comparative neurology.

[78]  A. Damasio,et al.  Severe disturbance of higher cognition after bilateral frontal lobe ablation , 1985, Neurology.

[79]  G. Bonin,et al.  The neocortex of Macaca mulatta , 1947 .

[80]  J. A. McDonald,et al.  Orality, Preference Behavior, and Reinforcement Value of Nonfood Object in Monkeys with Orbital Frontal Lesions , 1969, Science.

[81]  D. Amaral,et al.  Cholinergic innervation of the monkey amygdala: An immunohistochemical analysis with antisera to choline acetyltransferase , 1989, The Journal of comparative neurology.