Using diffusion MRI for measuring the temperature of cerebrospinal fluid within the lateral ventricles

Aim:  Hypothermia is often induced to reduce brain injury in newborns, following perinatal hypoxic–ischaemic events, and in adults following traumatic brain injury, stroke or cardiac arrest. We aimed to devise a method, based on diffusion‐weighted MRI, to measure non‐invasively the temperature of the cerebrospinal fluid in the lateral ventricles.

[1]  R. Mills,et al.  Self-diffusion in normal and heavy water in the range 1-45.deg. , 1973 .

[2]  M. Mann,et al.  Integrated analysis of the cerebrospinal fluid peptidome and proteome. , 2008, Journal of proteome research.

[3]  Derek K. Jones,et al.  RESTORE: Robust estimation of tensors by outlier rejection , 2005, Magnetic resonance in medicine.

[4]  A. Whitelaw,et al.  The Newborn Brain: Clinical assessment and therapeutic interventions for hypoxic–ischemic encephalopathy in the full-term infant , 2010 .

[5]  L. Mcilvoy.  The effect of hypothermia and hyperthermia on acute brain injury. , 2005, AACN clinical issues.

[6]  H. Hartung,et al.  Cerebrospinal fluid biomarkers in multiple sclerosis , 2009, Neurobiology of Disease.

[7]  Single‐shot diffusion‐weighted RARE sequence: Application for temperature monitoring during hyperthermia session , 1998 .

[8]  J. Pickard.  Physiology and Pathophysiology of the Cerebrospinal Fluid , 1988 .

[9]  P. Kingsley,et al.  Selection of the optimum b factor for diffusion‐weighted magnetic resonance imaging assessment of ischemic stroke , 2004, Magnetic resonance in medicine.

[10]  E. Purcell,et al.  Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments , 1954 .

[11]  M. Horsfield,et al.  Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging , 1999, Magnetic resonance in medicine.

[12]  A. Edwards,et al.  Mild Hypothermia after Severe Transient Hypoxia-Ischemia Ameliorates Delayed Cerebral Energy Failure in the Newborn Piglet , 1995, Pediatric Research.

[13]  Diederik Dippel,et al.  Therapeutic hypothermia in acute ischemic stroke , 2007, Expert review of neurotherapeutics.

[14]  D Le Bihan,et al.  Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia. , 1989, Radiology.

[15]  Thomas Brinker,et al.  Multiplicity of cerebrospinal fluid functions: New challenges in health and disease , 2008, Cerebrospinal Fluid Research.

[16]  C. Cuénod,et al.  Simultaneous temperature and regional blood volume measurements in human muscle using an MRI fast diffusion technique , 1993, Magnetic resonance in medicine.

[17]  J. Penrice,et al.  The Estimation of Local Brain Temperature by in Vivo 1H Magnetic Resonance Spectroscopy , 1995, Magnetic resonance in medicine.

[18]  Lewis R. Lipsey,et al.  The Merck Manual of Diagnosis and Therapy , 1988, The Yale Journal of Biology and Medicine.

[19]  R. Green,et al.  Systematic review of randomized controlled trials of therapeutic hypothermia as a neuroprotectant in post cardiac arrest patients. , 2006, CJEM.

[20]  Nick C Fox,et al.  Imaging cadavers: Cold FLAIR and noninvasive brain thermometry using CSF diffusion , 2008, Magnetic resonance in medicine.

[21]  Kim Butts Pauly,et al.  MR thermometry , 2008, Journal of magnetic resonance imaging : JMRI.

[22]  R. Busto,et al.  Postischemic moderate hypothermia inhibits CA1 hippocampal ischemic neuronal injury , 1989, Neuroscience Letters.

[23]  Laura Mcilvoy,et al.  Comparison of brain temperature to core temperature: a review of the literature. , 2004, The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.

[24]  N. Ellison,et al.  The Merck Manual of Diagnosis and Therapy. 17th ed. , 1999 .

[25]  K. Il'yasov,et al.  Single-shot diffusion-weighted RARE sequence: application for temperature monitoring during hyperthermia session. , 1998, Journal of magnetic resonance imaging : JMRI.

[26]  Hugh Davson,et al.  Physiology and Pathophysiology of the Cerebrospinal Fluid , 1987 .

[27]  Ji-yao Jiang,et al.  Current status of cerebral protection with mild-to-moderate hypothermia after traumatic brain injury , 2007, Current opinion in critical care.

[28]  J. Poorter,et al.  Noninvasive MRI Thermometry with the Proton Resonance Frequency (PRF) Method: In Vivo Results in Human Muscle , 1995, Magnetic resonance in medicine.

[29]  T. A. Carpenter,et al.  Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain. , 1997, Magnetic resonance imaging.

[30]  P. Grenier,et al.  MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. , 1986, Radiology.

[31]  Nikolaus Weiskopf,et al.  A method for improving the performance of gradient systems for diffusion-weighted MRI , 2007, Magnetic resonance in medicine.

[32]  E. Cady,et al.  Improved, pathology-resilient, magnetic resonance spectroscopy measurement of regional-brain absolute temperature in newborn infants. , 2007 .