Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.

Interest in using (68)Ga is rapidly increasing for clinical PET applications due to its favorable imaging characteristics and increased accessibility. The focus of this study was to provide our long-term evaluations of the two TiO(2)-based (68)Ge/(68)Ga generators and develop an optimized automation strategy to synthesize [(68)Ga]DOTATOC by using HEPES as a buffer system. This data will be useful in standardizing the evaluation of (68)Ge/(68)Ga generators and automation strategies to comply with regulatory issues for clinical use.

[1]  C Decristoforo,et al.  Full automation of (68)Ga labelling of DOTA-peptides including cation exchange prepurification. , 2010, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[2]  E. Krenning,et al.  (68)Ga-labeled DOTA-peptides and (68)Ga-labeled radiopharmaceuticals for positron emission tomography: current status of research, clinical applications, and future perspectives. , 2011, Seminars in nuclear medicine.

[3]  M. Haratake,et al.  A new 68Ge/68Ga generator system using an organic polymer containing N-methylglucamine groups as adsorbent for 68Ge. , 2003, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[4]  C. Nanni,et al.  Gallium-68 PET: a new frontier in receptor cancer imaging. , 2007, Anticancer research.

[5]  V. Ambrosini,et al.  68Ga-DOTA-NOC PET/CT detects somatostatin receptors expression in von hippel-lindau cerebellar disease. , 2011, Clinical nuclear medicine.

[6]  D. Vaknin,et al.  Determination of HEPES in 68Ga-labeled peptide solutions , 2010 .

[7]  E. Krenning,et al.  Characteristics of SnO2-based 68Ge/68Ga generator and aspects of radiolabelling DOTA-peptides. , 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[8]  D. Rubello,et al.  Clinical indications for Gallium-68 positron emission tomography imaging. , 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[9]  Marion de Jong,et al.  Radiolabelling DOTA-peptides with 68Ga , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[10]  F. Rösch,et al.  Improved column-based radiochemical processing of the generator produced 68Ga. , 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[11]  Roland Haubner,et al.  A fully automated synthesis for the preparation of 68Ga-labelled peptides , 2007, Nuclear medicine communications.

[12]  B. Långström,et al.  Microwave-supported preparation of (68)Ga bioconjugates with high specific radioactivity. , 2004, Bioconjugate chemistry.

[13]  G. I. Gleason.  A positron cow. , 1960, The International journal of applied radiation and isotopes.

[14]  F. Rösch,et al.  NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging. , 2008, Bioorganic & medicinal chemistry letters.

[15]  Markus Jahn,et al.  Processing of Generator-Produced 68Ga for Medical Application , 2007, Journal of Nuclear Medicine.

[16]  D. Rubello,et al.  What can gallium-68 PET add to receptor and molecular imaging? , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[17]  Xiankai Sun,et al.  PET with non-standard nuclides. , 2010, Current topics in medicinal chemistry.

[18]  M. Welch,et al.  A new germanium-63/gallium-68 generator. , 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  Guy Bormans,et al.  Optimal buffer choice of the radiosynthesis of 68Ga–Dotatoc for clinical application , 2010, Nuclear medicine communications.

[20]  W. Breeman,et al.  The 68Ge/68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine? , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[21]  P. Schöffski,et al.  Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data , 2001, European Journal of Nuclear Medicine.