Need for a Specialized Metamodel for Biomedical and Health Informatics Domain

The history of computing has taught the software community significant lessons and few of them in a hard way. After spending numerous resources, the community has realized the need for establishing standards or specification for efficiently handling interoperability issues across diverse applications and tools. For example, UML for model driven development, and XML for information exchange. The domain of biomedical informatics is traversing through a similar path where numerous resources are employed for achieving interoperability among heterogeneous biomedical applications. To mitigate this issue and learning from previous experiences, the biomedical domain has to establish a modeling standard for design and development of its software applications and tools. Towards this goal, this research article proposes a minimal metamodel for the domain of biomedical and health informatics based on MOF and UMLS Semantic Network.

[1]  Laura Plaza,et al.  Retrieval of Similar Electronic Health Records Using UMLS Concept Graphs , 2010, NLDB.

[2]  Kensaku Kawamoto,et al.  Viewpoint Paper: The Clinical Document Architecture and the Continuity of Care Record: A Critical Analysis , 2006, J. Am. Medical Informatics Assoc..

[3]  Olivier Bodenreider,et al.  The Unified Medical Language System (UMLS): integrating biomedical terminology , 2004, Nucleic Acids Res..

[4]  James Geller,et al.  Rule-based support system for multiple UMLS semantic type assignments , 2013, J. Biomed. Informatics.

[5]  Sunghwan Sohn,et al.  Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES): architecture, component evaluation and applications , 2010, J. Am. Medical Informatics Assoc..

[6]  Keith W. Boone.  The CDA TM book , 2011 .

[7]  Yan Chen,et al.  Expanding the extent of a UMLS semantic type via group neighborhood auditing. , 2009, Journal of the American Medical Informatics Association : JAMIA.

[8]  Rishi Saripalle,et al.  UMLS Semantic Network as a UML Metamodel for Improving Biomedical Ontology and Application Modeling , 2015, Int. J. Heal. Inf. Syst. Informatics.

[9]  James Geller,et al.  Partitioning the UMLS semantic network , 2002, IEEE Transactions on Information Technology in Biomedicine.

[10]  B. G. Ozdemir,et al.  Alternative representations of Unified Medical Language System Semantic Network elements in Web Ontology Language , 2011, 2011 International Symposium on Innovations in Intelligent Systems and Applications.

[11]  James Geller,et al.  Overcoming an obstacle in expanding a UMLS semantic type extent , 2012, J. Biomed. Informatics.

[12]  James Geller,et al.  Research Paper: Representing the UMLS as an Object-oriented Database: Modeling Issues and Advantages , 2000, J. Am. Medical Informatics Assoc..

[13]  Ling Chen,et al.  A chemical specialty semantic network for the Unified Medical Language System , 2012, Journal of Cheminformatics.

[14]  Betsy L. Humphreys,et al.  Technical Milestone: The Unified Medical Language System: An Informatics Research Collaboration , 1998, J. Am. Medical Informatics Assoc..

[15]  Vipul Kashyap,et al.  Representing the UMLS Semantic Network Using OWL: (Or "What's in a Semantic Web Link?") , 2003, SEMWEB.