Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.
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M. Giacca | A. Bardelli | D. Delia | M. Mano | E. Fontanella | D. Lecis | Maria Teresa Majorini | A. Conti
[1] Yufeng Shen,et al. Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] E. F. da Cruz e Silva,et al. Protein phosphatase 1 is a key player in nuclear events. , 2015, Cellular signalling.
[3] N. Bradbury,et al. Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy , 2015, Oncotarget.
[4] J. Werner,et al. Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis. , 2015, Cancer cell.
[5] A. Ashworth,et al. Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway , 2015, Oncotarget.
[6] D. Lawrence,et al. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis , 2014, Science.
[7] H. Walczak,et al. Getting TRAIL back on track for cancer therapy , 2014, Cell Death and Differentiation.
[8] H. Walczak,et al. TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells , 2014, Oncogene.
[9] M. El-Bahrawy,et al. Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1 , 2013, Cell Death and Differentiation.
[10] A. Letai,et al. Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis , 2013, Apoptosis.
[11] M. Colombo,et al. Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity , 2013, Cell Death and Disease.
[12] M. Fardilha,et al. Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain , 2013, Journal of Molecular Neuroscience.
[13] M. Bolognesi,et al. Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization. , 2012, Bioorganic & medicinal chemistry.
[14] Yoo Jin Jung,et al. The transcriptional landscape and mutational profile of lung adenocarcinoma , 2012, Genome research.
[15] Alessio Vagnoni,et al. Cdk5/p35 phosphorylates lemur tyrosine kinase‐2 to regulate protein phosphatase‐1C phosphorylation and activity , 2012, Journal of neurochemistry.
[16] Margarida Fardilha,et al. Identification of the human testis protein phosphatase 1 interactome. , 2011, Biochemical pharmacology.
[17] K. Lau,et al. Lemur tyrosine kinase-2 signalling regulates kinesin light chain-2 phosphorylation and binding of Smad2 cargo , 2011, Oncogene.
[18] S. Digumarthy,et al. BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. , 2011, Cancer discovery.
[19] F. Wandosell,et al. Deconstructing GSK-3: The Fine Regulation of Its Activity , 2011, International journal of Alzheimer's disease.
[20] G. Gores,et al. A smac mimetic reduces TNF Related Apoptosis Inducing Ligand (TRAIL)‐induced invasion and metastasis of cholangiocarcinoma cells , 2010, Hepatology.
[21] Paul McCullagh,et al. Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer , 2010, BMC Cancer.
[22] M. Bolognesi,et al. Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib , 2010, British Journal of Cancer.
[23] A. Kibel. Multiple newly identified loci associated with prostate cancer susceptibility , 2009 .
[24] Ceri M. Wiggins,et al. Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene‐targeted therapeutics , 2009, The FEBS journal.
[25] F. Buss,et al. Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis , 2009, Oncogene.
[26] R. Herbst,et al. To kill a tumor cell: the potential of proapoptotic receptor agonists. , 2008, The Journal of clinical investigation.
[27] O. Ohara,et al. BREK/LMTK2 is a myosin VI‐binding protein involved in endosomal membrane trafficking , 2008, Genes to cells : devoted to molecular & cellular mechanisms.
[28] Ali Amin Al Olama,et al. Multiple newly identified loci associated with prostate cancer susceptibility , 2008, Nature Genetics.
[29] F. Buss,et al. Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment , 2007, Journal of Cell Science.
[30] N. Yoshida,et al. Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene , 2006, Proceedings of the National Academy of Sciences.
[31] D. Inta,et al. Bim and Noxa Are Candidates to Mediate the Deleterious Effect of the NF-κB Subunit RelA in Cerebral Ischemia , 2006, The Journal of Neuroscience.
[32] Andreas Untergasser,et al. Preclinical Differentiation between Apparently Safe and Potentially Hepatotoxic Applications of TRAIL Either Alone or in Combination with Chemotherapeutic Drugs , 2006, Clinical Cancer Research.
[33] Jun Qin,et al. Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin , 2005 .
[34] G. Pigino,et al. A novel CDK5‐dependent pathway for regulating GSK3 activity and kinesin‐driven motility in neurons , 2004, The EMBO journal.
[35] Tadashi Yamamoto,et al. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling , 2004, Genes to cells : devoted to molecular & cellular mechanisms.
[36] Eun Hee Kim,et al. Roscovitine sensitizes glioma cells to TRAIL-mediated apoptosis by downregulation of survivin and XIAP , 2004, Oncogene.
[37] C. Shaw,et al. Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase , 2003, The Journal of Neuroscience.
[38] Hong Wang,et al. A Novel Transmembrane Ser/Thr Kinase Complexes with Protein Phosphatase-1 and Inhibitor-2* , 2002, The Journal of Biological Chemistry.
[39] J. Woodgett,et al. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[40] Henning Walczak,et al. TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL , 1997, The EMBO journal.
[41] John Calvin Reed,et al. Immunohistochemical analysis of in vivo patterns of Bcl-X expression. , 1994, Cancer research.
[42] M. Pierotti,et al. bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. , 1992, Blood.
[43] Jun Qin,et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. , 2005, Molecular cell.