fMRI of the lumbar spinal cord during a lower limb motor task

This study applied spinal fMRI to the lumbar spinal cord during lower limb motor activity. During active ankle movement, activity was detected in the lumbar spinal cord motor areas and sensory areas bilaterally. During passive ankle movement, activity was detected in the motor and sensory areas in lower lumbar spinal cord segments and motor activity in higher lumbar spinal cord segments. Spinal fMRI detects patterns of activity consistent with known physiology and can be used to reliably assess activity in the lumbar spinal cord during lower limb motor stimulation. This study affirms spinal fMRI as an effective tool for assessing spinal cord function and increases its potential as a clinical tool. Magn Reson Med 52:411–414, 2004. © 2004 Wiley‐Liss, Inc.

[1]  S. Ogawa.  Brain magnetic resonance imaging with contrast-dependent oxygenation , 1990 .

[2]  N. Logothetis,et al.  Neurophysiological investigation of the basis of the fMRI signal , 2001, Nature.

[3]  D. Tank,et al.  Functional Brain Mapping Using Magnetic Resonance Imaging: Signal Changes Accompanying Visual Stimulation , 1992, Investigative radiology.

[4]  P. Stroman,et al.  Noninvasive assessment of the injured human spinal cord by means of functional magnetic resonance imaging , 2004, Spinal Cord.

[5]  P. W Stroman,et al.  Functional magnetic resonance imaging at 0.2 Tesla , 2003, NeuroImage.

[6]  J. Dostrovsky,et al.  Differential projections of thermoreceptive and nociceptive lamina I trigeminothalamic and spinothalamic neurons in the cat. , 2001, Journal of neurophysiology.

[7]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[8]  P W Stroman,et al.  Functional magnetic resonance imaging of the human cervical spinal cord with stimulation of different sensory dermatomes. , 2002, Magnetic resonance imaging.

[9]  P. Stroman,et al.  Functional MRI of motor and sensory activation in the human spinal cord. , 2001, Magnetic resonance imaging.

[10]  P. W. Stroman,et al.  Mapping of Neuronal Function in the Healthy and Injured Human Spinal Cord with Spinal fMRI , 2002, NeuroImage.

[11]  P. Stroman,et al.  Characterization of contrast changes in functional MRI of the human spinal cord at 1.5 T. , 2001, Magnetic Resonance Imaging.

[12]  P. Stroman,et al.  Extravascular proton‐density changes as a non‐BOLD component of contrast in fMRI of the human spinal cord , 2002, Magnetic resonance in medicine.

[13]  D. Tank,et al.  Brain magnetic resonance imaging with contrast dependent on blood oxygenation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.