Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying ANG variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is higher than expected based on chance occurrence. We therefore investigated whether ANG variants could predispose to both ALS and PD.

Edwin Cuppen | Christine Klein | Dagmar Verbaan | Daniela Berg | Thomas Gasser | Peter Heutink | Robin Lemmens | Wim Robberecht | Claudia Schulte | Ewout J. N. Groen | Nicola Ticozzi | Vincenzo Silani | Caroline Dahlberg | Hans Scheffer | R. Ophoff | Robert H. Brown | P. D. de Bakker | B. Bloem | E. Cuppen | R. Folkerth | P. Andersen | A. Birve | H. Blauw | F. Diekstra | J. Landers | W. Robberecht | P. van Damme | L. H. van den Berg | M. V. van Es | P. V. van Vught | J. Veldink | D. Berg | G. Hu | C. Mariani | J. J. van Hilten | P. Heutink | H. J. Schelhaas | T. Gasser | A. Ludolph | D. Verbaan | H. Scheffer | C. Schulte | P. Keagle | C. Klein | Markus Weber | W. van Rheenen | N. Ticozzi | V. Silani | R. Fernández-Santiago | C. Dahlberg | R. Pasterkamp | M. Koppers | K. Fumoto | S. Goldwurm | Wenhao Yu | G. Pezzoli | R. Lemmens | A. J. van der Kooi | M. de Visser | Stefano Goldwurm | Claudio Mariani | Bastiaan R. Bloem | E. Hennekam | Gianni Pezzoli | Marianne de Visser | Markus Weber | Marka van Blitterswijk | S. Waibel | A. L. Leclerc | Philip Van Damme | M. van Blitterswijk | Guo-fu Hu | Robert H. Brown | Helenius J. Schelhaas | Anna Birve | Albert C. Ludolph | Paul I. W. de Bakker | Anne-Marie Wills | H. Kishikawa | Michael A. van Es | Paul W. J. van Vught | Peter M. Andersen | Ewout J. N. Groen | Hylke M. Blauw | Max Koppers | Frank P. Diekstra | Katsumi Fumoto | Ashley Lyn LeClerc | Pamela Keagle | Bart F. L. van Nuenen | Wouter van Rheenen | Patrick P. Lowe | Wenhao Yu | Hiroko Kishikawa | David Wu | Rebecca D. Folkerth | Rubén Fernández-Santiago | Stefan Waibel | Anneke J. van der Kooi | Jacobus J. van Hilten | Eric A. M. Hennekam | Roel A. Ophoff | Jan H. Veldink | R. Jeroen Pasterkamp | John E. Landers | Bart P. van de Warrenburg | Leonard H. van den Berg | David Wu | P. Lowe | B. V. van Nuenen | A. Wills | B. V. D. van de Warrenburg | R. J. Pasterkamp | Robert H. Brown | Pamela J. Keagle

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