ADHD, Aggression, and Antisocial Behavior across the Lifespan

Abstract: The progression to adult antisocial behavior is the least desirable developmental trajectory for children with ADHD. An unremitting pattern of physical aggression appears of great import when predicting long‐term outcome. However, a profile characterized by behavioral and cognitive impulsivity and emotional lability may indicate a greater likelihood of the progression to adult antisocial behavior and violent impulse‐control disorders. This constellation of behaviors appears to be, at least in part, mediated by brain serotonergic systems. The contribution of cognitive impairments, as manifested by executive function deficits, diminished moral reasoning, and impaired empathic ability, to the emergence and persistence of antisocial behavior has yet to be discerned.

[1]  Abraham Weizman,et al.  Imipramine binding to platelets of children with attention deficit disorder with hyperactivity , 1988, Biological Psychiatry.

[2]  J. Rapoport,et al.  Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder , 1994, Psychiatry Research.

[3]  M. Linnoila,et al.  Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. , 1992, Archives of general psychiatry.

[4]  D L Newman,et al.  Behavioral observations at age 3 years predict adult psychiatric disorders. Longitudinal evidence from a birth cohort. , 1996, Archives of general psychiatry.

[5]  W. Faustman,et al.  An Association Between Low Levels of 5-HIAA and HVA in Cerebrospinal Fluid and Early Mortality in a Diagnostically Mixed Psychiatric Sample , 1993, British Journal of Psychiatry.

[6]  D. Hay,et al.  Key issues in the development of aggression and violence from childhood to early adulthood. , 1997, Annual review of psychology.

[7]  M. Åsberg,et al.  Cerebrospinal fluid studies in suicide. An overview. , 1986, Annals of the New York Academy of Sciences.

[8]  L. Siever,et al.  Age-related changes in the association between serotonergic function and aggression in boys with ADHD , 1997, Biological Psychiatry.

[9]  L. Robins,et al.  Association of Alcoholism with Antisocial Personality in Urban Men , 1985, The Journal of nervous and mental disease.

[10]  R. Loeber,et al.  Early predictors of male delinquency: a review. , 1983, Psychological bulletin.

[11]  K. Dodge,et al.  Social-information-processing factors in reactive and proactive aggression in children's peer groups. , 1987, Journal of personality and social psychology.

[12]  A. Schatzberg,et al.  Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. , 1995, Journal of clinical psychopharmacology.

[13]  E. Coccaro,et al.  An open trial of sertraline in personality disordered patients with impulsive aggression. , 1994, The Journal of clinical psychiatry.

[14]  M. Åsberg,et al.  Homicide, suicide and CSF 5‐HIAA , 1985, Acta psychiatrica Scandinavica.

[15]  R. Loeber.  Development and risk factors of juvenile antisocial behavior and delinquency. , 1990 .

[16]  D. Stoff,et al.  Reduction of (3H)-imipramine binding sites on platelets of conduct-disordered children. , 1987, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[17]  D. Magnusson,et al.  The role of early aggressive behavior in the frequency, seriousness, and types of later crime. , 1989, Journal of consulting and clinical psychology.

[18]  P. Mandel,et al.  Inhibition of mouse killing behavior by serotonin-mimetic drugs: Effects of partial alterations of serotonin neurotransmission , 1987, Pharmacology Biochemistry and Behavior.

[19]  Kenneth H. Rubin,et al.  The development and treatment of childhood aggression. , 1991 .

[20]  G. Hynd,et al.  Attention-Deficit Disorder With (ADD/H) and Without (ADD/WO) Hyperactivity: Behavioral and Neuropsychological Differentiation , 1992 .

[21]  B. Cooper,et al.  Biochemical and behavioural alterations following 5,6-dihydroxytryptamine administration into brain. , 1974, Neuropharmacology.

[22]  G. Barr,et al.  Effects of para-chlorophenylalanine and 5-hydroxytryptophan on mouse killing behavior in killer rats , 1978, Pharmacology Biochemistry and Behavior.

[23]  D. Stoff,et al.  Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents , 1992, Psychiatry Research.

[24]  I. Kolvin,et al.  Social and Parenting Factors Affecting Criminal-Offence Rates , 1988, British Journal of Psychiatry.

[25]  M Linnoila,et al.  Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. , 1983, Life sciences.

[26]  L. Siever,et al.  Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior. , 1989, Archives of general psychiatry.

[27]  M. Linnoila,et al.  Excessive mortality in young free-ranging male nonhuman primates with low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. , 1996, Archives of general psychiatry.

[28]  M. Linnoila,et al.  CSF serotonin metabolite (5-HIAA) studies in depression, impulsivity, and violence. , 1990, The Journal of clinical psychiatry.

[29]  A. Depaulis,et al.  Selective increase of offensive behavior in the rat following intrahypothalamic 5,7-DHT-induced serotonin depletion , 1988, Behavioural Brain Research.

[30]  J. Rapoport,et al.  A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Prediction by cerebrospinal fluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomic measures? , 1992, Archives of general psychiatry.

[31]  R. Tremblay,et al.  Early disruptive behavior, poor school achievement, delinquent behavior, and delinquent personality: longitudinal analyses. , 1992, Journal of consulting and clinical psychology.

[32]  David P. Farrington,et al.  Childhood aggression and adult violence: Early precursors and later-life outcomes. , 1991 .

[33]  D. Fergusson,et al.  Factors associated with continuity and changes in disruptive behavior patterns between childhood and adolescence , 1996, Journal of abnormal child psychology.

[34]  R. Barkley.  Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. , 1997, Psychological bulletin.

[35]  L. Nucci,et al.  Behavioral disordered children's conceptions of moral, conventional, and personal issues , 1982, Journal of abnormal child psychology.

[36]  J. Halperin,et al.  The factor structure of ADHD items in DSM-III-R: Internal consistency and external validation , 1993, Journal of abnormal child psychology.

[37]  W. J. Klein,et al.  Aggression, suicide, and serotonin: relationships to CSF amine metabolites. , 1982, The American journal of psychiatry.

[38]  F. Goodwin,et al.  DIAGNOSTIC, CLINICAL AND PERSONALITY CHARACTERISTICS OF AGGRESSIVE MEN WITH LOW 5-HIAA , 1984 .

[39]  P. Markowitz.  Effect of fluoxetine on self-injurious behavior in the developmentally disabled: a preliminary study. , 1992, Journal of clinical psychopharmacology.

[40]  Phil A. Silva,et al.  Temperamental qualities at age three predict personality traits in young adulthood: longitudinal evidence from a birth cohort. , 1995, Child development.

[41]  R. Milich,et al.  The hyperkinetic child grows up: Predictors of symptoms, delinquency, and achievement at follow-up , 1981 .

[42]  T. Dinan,et al.  Blunted Prolactin Responses to d-Fenfluramine in Sociopathy , 1992, British Journal of Psychiatry.

[43]  R. Loeber,et al.  Developmental sequences in the age of onset of disruptive child behaviors , 1992 .

[44]  J. Halperin,et al.  Gender Differences in the Prolactin Response to Fenfluramine Challenge in Children with Disruptive Behavior Disorders , 1996, Annals of the New York Academy of Sciences.

[45]  Yogesh K. Dwivedi,et al.  Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior. , 1995, The American journal of psychiatry.

[46]  M. Fava,et al.  Anger attacks in depressed outpatients and their response to fluoxetine , 1998, European Psychiatry.

[47]  D. Pine,et al.  Serotonergic and Cardiac Correlates of Aggression in Children a , 1996, Annals of the New York Academy of Sciences.

[48]  B. Birmaher,et al.  Platelet imipramine binding in children and adolescents with impulsive behavior. , 1990, Journal of the American Academy of Child and Adolescent Psychiatry.

[49]  J. Rapoport,et al.  Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. , 1990, Archives of general psychiatry.

[50]  R. Loeber,et al.  Developmental pathways in disruptive child behavior , 1993, Development and Psychopathology.

[51]  M. Linnoila,et al.  Stability of Interindividual Differences in Serotonin Function and Its Relationship to Severe Aggression and Competent Social Behavior in Rhesus Macaque Females , 1996, Neuropsychopharmacology.

[52]  R. Abbott,et al.  Predicting serious delinquency and substance use among aggressive boys. , 1995, Journal of consulting and clinical psychology.

[53]  B. Olivier,et al.  Rodent models of aggressive behavior and serotonergic drugs , 1992, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[54]  G. Patterson,et al.  Coercive Family Process , 1982 .

[55]  E. Coccaro,et al.  Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. , 1997, Archives of general psychiatry.

[56]  G. Barr,et al.  Manipulations of dietary tryptophan: Effects on mouse killing and brain serotonin in the rat , 1979, Brain Research.

[57]  F. Goodwin,et al.  Cerebrospinal fluid monoamine metabolite levels in male arsonists. , 1987, Archives of general psychiatry.

[58]  John M. Davis,et al.  Platelet serotonin-2 receptor binding sites in depression and suicide , 1990, Biological Psychiatry.

[59]  G. Weiss,et al.  Psychiatric status of hyperactives as adults: a controlled prospective 15-year follow-up of 63 hyperactive children. , 1985, Journal of the American Academy of Child Psychiatry.

[60]  M. Linnoila,et al.  Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. , 1994, The American journal of psychiatry.

[61]  L. Frank.  The Society for Research in Child Development , 1935 .

[62]  D. Stoff,et al.  Instrumental and hostile aggression in childhood disruptive behavior disorders , 1993, Journal of abnormal child psychology.

[63]  L. Siever,et al.  Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. , 1994, The American journal of psychiatry.

[64]  G. Barr,et al.  L-tryptophan's effects on mouse killing, feeding, drinking, locomotion, and brain serotonin , 1981, Pharmacology Biochemistry and Behavior.

[65]  D. Stoff,et al.  Platelet 3H-imipramine binding, serotonin uptake, and plasma α 1 acid glycoprotein in disruptive behavior disorders , 1991, Biological Psychiatry.

[66]  Thomas A. Kent,et al.  Blood platelet uptake of serotonin in episodic aggression , 1989, Psychiatry Research.

[67]  Y. Sarne,et al.  Imipramine binding to blood platelets and aggressive behavior in offenders, schizophrenics and normal volunteers. , 1995, Neuropsychobiology.

[68]  J. Zubieta,et al.  Is there a role of serotonin in the disruptive behavior disorders? A literature review. , 1993, Journal of child and adolescent psychopharmacology.

[69]  K. Dodge,et al.  The structure and function of reactive and proactive aggression. , 1991 .

[70]  V. Arango,et al.  Alterations in Monoamine Receptors in the Brain of Suicide Victims , 1992, Journal of clinical psychopharmacology.