Cutaneous Tuberculosis

M ycobacterium tuberculosis, Mycobacterium bovis, and rarely, the attenuated Bacillus Calmette-Cuerin vaccine (BCG) are responsible for causing cutaneous tuberculosis,^ "* The vole bacillius' used for vaccination in the past has been reported to cause lupus murinus at the site of inoculation, M, tuberculosis is a facultative, intracellular, aerobic, acid-fast bacillus, naturally pathogenic only for humans. Tubercle bacilli are slender, curved, delicate, often beaded or banded rods, 1 -4 jum long and about 0,5 /um in diameter,^'' occurring either singly, in pairs, or clumps. The bacilli are nonmotile, nonsporing, and noncapsulated.® They do not stain easily with the Gram stain because of their high lipid cell content, but once stained by the Ziehl-Neelsen method, they strongly resist decolorization with acid and alcohol,' The highly complex cell wall components (cord factor, high molecular weight lipids and waxes. Wax D, tuberculo-protein) determine the mycobacterial physiology and may influence the pattern of host re-

[1]  E. Wolinsky.  Nontuberculous mycobacteria and associated diseases. , 2015, The American review of respiratory disease.

[2]  G. Youmans,et al.  Relation between delayed hypersensitivity and immunity in tuberculosis. , 2015, The American review of respiratory disease.

[3]  T. Egsmose.  The effect of an exorbitant intracutaneous dose of 200 micrograms PPD tuberculin compared with 0.02 micrograms PPD tuberculin. , 2015, American Review of Respiratory Disease.

[4]  G. Mackaness.  The immunology of antituberculous immunity. , 2015, The American review of respiratory disease.

[5]  R. Vasanthi,et al.  Tuberculous cavernositis of the penis: case report. , 1989, Genitourinary medicine.

[6]  V. Sharma,et al.  Unusual Clinical Manifestations of Cutaneous Tuberculosis , 1988, The Journal of dermatology.

[7]  P. Sarojini,et al.  Primary Inoculation Tuberculosis. , 1988, Indian journal of dermatology, venereology and leprology.

[8]  V. Sharma,et al.  An Appraisal of Epidemiologic, Clinical, Bacteriologic, Histopathologic, and Immunologic Parameters in Cutaneous Tuberculosis , 1987, International journal of dermatology.

[9]  V. Sharma,et al.  Lupus vulgaris, caries of the spine and lichen scrofulosorum—an intriguing association , 1987, Clinical and experimental dermatology.

[10]  S. Kaufmann,et al.  Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. , 1987, Journal of immunology.

[11]  R. O'brien,et al.  Short-course chemotherapy of pulmonary tuberculosis. , 1987, The American review of respiratory disease.

[12]  B. Hudspith,et al.  Inhibition of virulent Mycobacterium tuberculosis by murine peritoneal macrophages and human alveolar lavage cells: the effects of lymphokines and recombinant gamma interferon. , 1986, Tubercle.

[13]  B. Champion,et al.  Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages. , 1986, Immunology.

[14]  M. Spiteri,et al.  Life threatening reaction to tuberculin testing. , 1986, British medical journal.

[15]  V. Spence,et al.  Patterns of blood flow in the microcirculation of the skin during the course of the tuberculin reaction in normal human subjects. , 1986, Immunology.

[16]  M. Hirata,et al.  Lack of tuberculin activity of synthetic peptides , 1985, Infection and immunity.

[17]  A. J. Crowle,et al.  Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria , 1985, Infection and immunity.

[18]  S. Debanne,et al.  ELISA of IgG antibody toM. tuberculosis antigen 5 for serodiagnosis of tuberculosis , 1985, Indian journal of pediatrics.

[19]  K. thestrup-pedersen,et al.  In vivo and in vitro changes in cell‐mediated immunity following tuberculin skin testing in humans , 1985, The British journal of dermatology.

[20]  D. Snider.  Bacille Calmette-Guérin vaccinations and tuberculin skin tests. , 1985, JAMA.

[21]  N. Tyagi,et al.  Tuberculin sensitivity in rural children. , 1985, Indian pediatrics.

[22]  B. Champion,et al.  I-A restricted activation by T cell lines of anti-tuberculosis activity in murine macrophages. , 1985, Clinical and experimental immunology.

[23]  L. Baldini,et al.  Variability in the intradermal and in vitro lymphocyte responses to PPD in patients receiving isoniazid chemoprophylaxis. , 1985, American Review of Respiratory Disease.

[24]  R. W. Baldwin,et al.  Liposomal encapsulation augments delayed hypersensitivity reactions to tuberculin proteins. , 1984, Journal of medical microbiology.

[25]  J. Morrison.  Lymphangitis after tuberculin tests , 1984, British medical journal.

[26]  N. Bhandari,et al.  Diagnostic value of BCG test in childhood tuberculosis. , 1984, Indian pediatrics.

[27]  A. Gupta,et al.  Antibodies to purified protein derivative in tuberculosis patients and its relationship with pulmonary lesion. , 1984, Indian journal of chest diseases & allied sciences.

[28]  J. Stanford,et al.  The use of a sonicate preparation of Mycobacterium tuberculosis (new tuberculin) in the assessment of BCG vaccination. , 1983, Tubercle.

[29]  J. Šavrda.  Synthesis and biological assays of peptides from a tuberculin-active protein , 1983, Infection and immunity.

[30]  W. van Eden,et al.  HLA-DR3 associated genetic control of response to multiple skin tests with new tuberculins. , 1983, Clinical and experimental immunology.

[31]  A. Kelso,et al.  Production of macrophage-activating factor by T lymphocyte clones and correlation with other lymphokine activities. , 1982, Journal of immunology.

[32]  A. Izumi,et al.  BCG vaccine-induced lupus vulgaris. , 1982, Archives of dermatology.

[33]  S. C. Stein.  Mycobacteria and the Skin , 1982, International journal of dermatology.

[34]  T. Datta,et al.  B.C.G. versus tuberculin test in the diagnosis of childhood tuberculosis. , 1982, Indian pediatrics.

[35]  P. Rottoli,et al.  Immune complexes in the spectrum of tuberculosis. , 1981, Tubercle.

[36]  M. McCray,et al.  Cutaneous eruptions in congenital tuberculosis. , 1981, Archives of dermatology.

[37]  V. N. Sehgal,et al.  Cell‐mediated immunity in cutaneous tuberculosis , 1981, The British journal of dermatology.

[38]  I. Azuma,et al.  Persistence of protein, carbohydrate and was components of tubercle bacilli in dermal BCG lesions. , 1981, The American review of respiratory disease.

[39]  G. Bahr,et al.  The effect of two distinct forms of cell-mediated response to mycobacteria on the protective efficacy of BCG. , 1981, Tubercle.

[40]  G. Rook,et al.  How environmental mycobacteria may predetermine the protective efficacy of BCG. , 1981, Tubercle.

[41]  A. Eisen,et al.  Cutaneous mycobacteriosis: analysis of 34 cases with a new classification of the disease. , 1981, Medicine.

[42]  A. J. Crowle,et al.  Preliminary demonstration of human tuberculoimmunity in vitro , 1981, Infection and immunity.

[43]  J. Grange,et al.  Immunological and clinical features of smear-positive pulmonary tuberculosis in East Java. , 1980, Tubercle.

[44]  D. Boros,et al.  The artificial granuloma 1: in vitro lymphokine production by pulmonary artificial hypersensitivity granulomas. , 1980, Clinical immunology and immunopathology.

[45]  D. Bateman,et al.  Miliary tuberculosis in association with chronic cutaneous tuberculosis , 1980, The British journal of dermatology.

[46]  R. Steinman,et al.  Dendritic cells of the mouse: identification and characterization. , 1980, The Journal of investigative dermatology.

[47]  J. Marks,et al.  Lupus vulgaris and cutaneous lymphoma , 1980, Clinical and experimental dermatology.

[48]  M. Desai,et al.  Cutaneous primary complex following venepuncture. , 1978, Indian Pediatrics.

[49]  G. Rook,et al.  Three forms of delayed skin-test response evoked by mycobacteria , 1978, Nature.

[50]  J. R. Fisher.  Miliary tuberculosis with unusual cutaneous manifestations. , 1977, JAMA.

[51]  R. Bhatnagar,et al.  Spectrum of immune response abnormalities in different clinical forms of tuberculosis. , 1977, The American review of respiratory disease.

[52]  P. Rottoli,et al.  The spectrum of human tuberculosis. , 1977, Clinical and experimental immunology.

[53]  A. Warin,et al.  Cutaneous tuberculosis of the nose with unusual clinical and histological features leading to delay in diagnosis , 1976, Clinical and experimental dermatology.

[54]  C. Schmitt,et al.  Lupus vulgaris: recovery of living tubercle bacilli 35 years after onset. , 1976, Cutis.

[55]  K. Saha,et al.  Tuberculin hypersensitivity before and after B.C.G. vaccination in Indian children of an urban community--a pilot study. , 1976, Indian Pediatrics.

[56]  A. Ajdukiewicz,et al.  Miliary tuberculosis presenting with multifocal oral lesions. , 1976, British medical journal.

[57]  S. Anand,et al.  Systemic amyloidosis in psoriasis, lepromatous leprosy & cutaneous tuberculosis. , 1976, Indian journal of dermatology.

[58]  B. Webber,et al.  Primary tuberculous complex of the skin. , 1976, JAMA.

[59]  G. Knowles,et al.  Miliary Tuberculosis Presenting with skin lesions. , 1975, British medical journal.

[60]  S. Sahn,et al.  Primary cutaneous inoculation drug-resistant tuberculosis. , 1974, The American journal of medicine.

[61]  J. Grange,et al.  The meaning and structure of species as applied to mycobacteria. , 1974, Tubercle.

[62]  R. Rickert,et al.  Verrucous tuberculosis of the anal canal: Report of a case , 1974, Diseases of the colon and rectum.

[63]  I. D. London.  Primary cutaneous inoculation tuberculosis. , 1972, Archives of dermatology.

[64]  H. R. Vickers,et al.  Lupus vulgaris and Hodgkin's disease. , 1972, Archives of dermatology.

[65]  E. Hunt,et al.  Serial tuberculin testing and isoniazid therapy in general hospital employees. , 1971, JAMA.

[66]  D. Alarcón-Segovia,et al.  Serum immunoglobulins in pulmonary tuberculosis. , 1971, Chest.

[67]  R. Fine,et al.  PSORIASIFORM LUPUS VULGARIS: A CASE REPORT , 1970, International journal of dermatology.

[68]  W. Howard,et al.  The loss of tuberculin sensitivity in certain patients with active pulmonary tuberculosis. , 1970, Chest.

[69]  F. Glickman,et al.  Primary inoculation complex (tuberculous chancre). , 1969, Archives of dermatology.

[70]  G. Wilner,et al.  Fluorescent staining for mycobacteria in sarcoid and tuberculous granulomas. , 1969, American journal of clinical pathology.

[71]  K. J. Carruthers.  Comparison of the Heaf (multiple puncture) and Mantoux tests using several tuberculins. , 1969, Tubercle.

[72]  S. Minkowitz,et al.  "Prosector's wart" (cutaneous tuberculosis) in a medical student. , 1969, American journal of clinical pathology.

[73]  S. Chiu,et al.  TUBERCULOSIS OF THE SKIN IN HONG KOKG (A REVIEW OF 160 CASES) , 1968, The British journal of dermatology.

[74]  R. Patnode,et al.  Serum protein and immunoglobulin levels in tuberculosis. , 1967, American journal of clinical pathology.

[75]  P. D. Hart,et al.  Efficacy and applicability of mass B. C.G. vaccination in tuberculosis control. , 1967, British medical journal.

[76]  T. M. Daniel,et al.  Reversion of recently acquired tuberculin reactivity during isoniazid prophylaxis. , 1967, The American review of respiratory disease.

[77]  C. Palmer,et al.  Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis. , 1966, The American review of respiratory disease.

[78]  M. Orkin,et al.  Primary tuberculosis of the skin. Primary complex. , 1966, JAMA.

[79]  K. Heilman,et al.  Primary cutaneous tuberculosis resulting from mouth-to-mouth respiration. , 1965, The New England journal of medicine.

[80]  H. Braunstein,et al.  Fluorescent Stain for Tubercle Bacilli in Histologic Sections , 1965 .

[81]  R. Côté,et al.  COMPARISON OF FLUORESCENCE MICROSCOPY WITH ZIEHL-NEELSEN STAIN FOR DEMONSTRATION OF ACID-FAST BACILLI IN SMEAR PREPARATIONS AND TISSUE SECTIONS. , 1965, The American review of respiratory disease.

[82]  R. Johnston,et al.  Declining Tuberculin Sensitivity with Advancing Age , 1963, British medical journal.

[83]  T. Noble,et al.  Four cases of syringe-transmitted tuberculosis. , 1961, Tubercle.

[84]  O. Horwitz,et al.  Numerical estimates of the extent of the lesion in lupus vulgaris cutis and their significance for epidemiologic and clinical research. , 1960, The American review of respiratory disease.

[85]  H. Hurley,et al.  Sarcoid granulomas after intradermal tuberculin in normal human skin. , 1960, Archives of dermatology.

[86]  J. Bene,et al.  [Tuberculosis of the tongue]. , 1960, Tuberkulozis.

[87]  J. Zoon.  Tuberculosis of the skin; considerations about pathogenesis. , 1957, A.M.A. archives of dermatology.

[88]  F. Miller,et al.  The natural history of peripheral tuberculous lymphadenitis associated with a visible primary focus. , 1955, Lancet.

[89]  B. Russell.  The History of Lupus Vulgaris: Its Recognition, Nature, Treatment and Prevention , 1955, Proceedings of the Royal Society of Medicine.

[90]  P. C. Mitchell.  TUBERCULOSIS VERRUCOSA CUTIS AMONG CHINESE IN HONG KONG. , 1954, The British journal of dermatology.

[91]  E. Escalona,et al.  Isoniazid (isonicotinic acid hydrazide) in skin tuberculosis; preliminary report of sixteen cases. , 1954, A.M.A. archives of dermatology and syphilology.

[92]  A. Lees,et al.  Skin Lesions and Deafness in Disseminated Tuberculosis , 1954, British medical journal.

[93]  C. N. Iland,et al.  Electrophoretic studies of the serum proteins in tuberculosis. , 1953, American review of tuberculosis.

[94]  F. Miller.  Recognition of primary tuberculous infection of skin and mucosae. , 1953, Lancet.

[95]  H. Ustvedt,et al.  The relation between tuberculosis of the skin and primary infection , 1951 .

[96]  R. Dubos,et al.  VIRULENCE AND MORPHOLOGICAL CHARACTERISTICS OF MAMMALIAN TUBERCLE BACILLI , 1947, The Journal of experimental medicine.

[97]  R. Scott.  PRIMARY INOCULATION TUBERCULOSIS OF THE SKIN: ITS OCCURRENCE IN A FOUR YEAR OLD CHILD , 1941 .

[98]  H. K. Fidler.  THE PRIMARY CUTANEOUS TUBERCULOSIS COMPLEX , 1937 .

[99]  H. Montgomery.  HISTOPATHOLOGY OF VARIOUS TYPES OF CUTANEOUS TUBERCULOSIS , 1937 .

[100]  H. Michelson.  THE PRIMARY COMPLEX OF TUBERCULOSIS OF THE SKIN: REVIEW OF THE LITERATURE , 1935 .

[101]  A. Griffith.  INVESTIGATIONS OF STRAINS OF TUBERCLE BACILLI DERIVED FROM SPUTUM. , 1916 .

[102]  H. Mendes.  Tuberculosis Acquired through Ritual Circumcision , 1913 .

[103]  G. Rook.  Role of activated macrophages in the immunopathology of tuberculosis. , 1988, British medical bulletin.

[104]  P. Fine,et al.  BCG vaccination against tuberculosis and leprosy. , 1988, British medical bulletin.

[105]  S. Lucas,et al.  Histopathology of leprosy and tuberculosis--an overview. , 1988, British medical bulletin.

[106]  G. Bothamley,et al.  Immunodiagnostic assays for tuberculosis and leprosy. , 1988, British medical bulletin.

[107]  G. Rook,et al.  Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. , 1986, Immunology.

[108]  อรทัย พูาชีรัตน์,et al.  Tuberculosis Cutis Miliaris Acuta Generalisata รายงานผู้ป่วยและทบทวนวารสาร , 1984 .

[109]  G. Rook,et al.  Environmental mycobacteria and immunization with BCG , 1983 .

[110]  C. Wan Ihm,et al.  Lupus tumidus involving facial skin, nasal cavity, throat and eye (with 1 color plate). , 1983, Dermatologica.

[111]  J. Šavrda.  Synthesis and biological assays of peptides from a tuberculin-active protein. , 1983, Infection and Immunity.

[112]  Effectiveness of BCG vaccination in Great Britain in 1978. A report from the Research Committee of the British Thoracic Association. , 1980, British journal of diseases of the chest.

[113]  Trial of BCG vaccines in south India for tuberculosis prevention: first report--Tuberculosis Prevention Trial. , 1979, Bulletin of the World Health Organization.

[114]  Trial of BCG vaccines in south India for tuberculosis prevention. , 1979, The Indian journal of medical research.

[115]  U. Chaturvedi,et al.  Immunological classification of pulmonary tuberculosis. , 1978 .

[116]  A. Kanwar,et al.  Cutaneous tuberculosis--a clinical and investigative study. , 1977, Indian journal of dermatology.

[117]  R. Gupta,et al.  Levels of serum immunoglobulins in pulmonary tuberculosis patients. , 1974, The Indian journal of chest diseases.

[118]  A. Orfuss.  Lupus vulgaris and superimposed basal cell epitheliomas. , 1971, Archives of dermatology.

[119]  K. P. Glynn.  Isolated subcutaneous abscesses caused by Mycobacterium tuberculosis. , 1969, The American review of respiratory disease.

[120]  J. R. Johnson,et al.  Serum proteins in pulmonary tuberculosis. , 1967, Diseases of the chest.

[121]  C. Brück,et al.  Treatment of lupus vulgaris with INH exclusively. , 1964, Acta dermato-venereologica.

[122]  B. Waksman,et al.  TUBERCULIN SENSITIVITY. IMMUNOLOGIC CONSIDERATIONS. , 1964, Bibliotheca tuberculosea.

[123]  B. Magnusson.  THE INFLUENCE OF CORTISONE AND HYDROCORTISONE ON THE TUBERCULIN REACTION. , 1963, Acta dermato-venereologica.

[124]  P. Marcussen,et al.  Treatment of lupus vulgaris with INH, PAS, and Tebamine. , 1961, Acta dermato-venereologica.

[125]  O. Horwitz.  Lupus vulgaris cutis in Denmark, 1895-1954. Its relation to the epidemiology of other forms of tuberculosis. Epidemiology and course of the tuberculous infection, based on 3902 cases from the Finsen Institue, Copenhagen. , 1960, Acta tuberculosea Scandinavica. Supplementum.

[126]  R. V. Platou,et al.  Tuberculous cutaneous complexes in children. , 1957, The Bulletin of the Tulane Medical Faculty.

[127]  O. Horwitz,et al.  The safety record of BCG vaccination and untoward reactions observed after vaccination. , 1957, Bibliotheca tuberculosea.

[128]  J. Hoey.  Tuberculosis today. , 1956, Nursing Outlook.

[129]  M. Wiggins,et al.  Self-inoculation with M. tuberculosis and Ps. Aeruginosa by a diabetic woman. , 1954, American review of tuberculosis.

[130]  S. Hellerstróm.  Collected cases of inoculation lupus vulgaris. , 1951, Acta dermato-venereologica.

[131]  Z. Kovacs.  Sarcoma in lupo. , 1951, Dermatologica.

[132]  D. I. Williams.  Tuberculosis of the skin. , 1950, The Practitioner.

[133]  G. Riehl,et al.  [Tuberculosis of the skin and its treatment]. , 1950, Wiener Beitrage zur Dermatologie.

[134]  H. Schwabacher,et al.  The Effect of the Desensitisation of Tuberculous Guinea-Pigs. , 1940 .