The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization

[1]  A. Rohou,et al.  Structural basis of α-scorpion toxin action on Nav channels , 2019, Science.

[2]  A. Rohou,et al.  Structural basis of alpha-scorpion toxin action on Navchannels. , 2019 .

[3]  Hui Xu,et al.  Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin , 2019, Cell.

[4]  Alexis Rohou,et al.  Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin , 2019, Cell.

[5]  R. Stroud,et al.  Structural basis for activation of voltage sensor domains in an ion channel TPC1 , 2018, Proceedings of the National Academy of Sciences.

[6]  V. A. Klenchin,et al.  Bipolar switching by HCN voltage sensor underlies hyperpolarization activation , 2018, Proceedings of the National Academy of Sciences.

[7]  W. N. Zagotta,et al.  Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels , 2018, Proceedings of the National Academy of Sciences.

[8]  W. N. Zagotta,et al.  Visualizing conformational dynamics of proteins in solution and at the cell membrane , 2018, bioRxiv.

[9]  W. N. Zagotta,et al.  Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels , 2018, The Journal of general physiology.

[10]  X. Bai,et al.  Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel , 2018, Nature.

[11]  W. N. Zagotta,et al.  Structural insights into the mechanisms of CNBD channel function , 2018, The Journal of general physiology.

[12]  William A Catterall,et al.  The chemical basis for electrical signaling. , 2017, Nature chemical biology.

[13]  E. Isacoff,et al.  A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore , 2017, The Journal of general physiology.

[14]  W. N. Zagotta,et al.  Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels , 2017, eLife.

[15]  R. MacKinnon,et al.  Structures of the Human HCN1 Hyperpolarization-Activated Channel , 2017, Cell.

[16]  W. N. Zagotta,et al.  Regulation of CNGA1 Channel Gating by Interactions with the Membrane* , 2016, The Journal of Biological Chemistry.

[17]  Sharona E. Gordon,et al.  Transition metal ion FRET to measure short-range distances at the intracellular surface of the plasma membrane , 2016, The Journal of general physiology.

[18]  Sharona E. Gordon,et al.  Measuring distances between TRPV1 and the plasma membrane using a noncanonical amino acid and transition metal ion FRET , 2016, The Journal of general physiology.

[19]  Youxing Jiang,et al.  Structure of Voltage-gated Two-pore Channel TPC1 from Arabidopsis thaliana , 2015, Nature.

[20]  L. Pardo,et al.  Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains , 2015, Nature Communications.

[21]  David Baker,et al.  High-resolution comparative modeling with RosettaCM. , 2013, Structure.

[22]  P. Schultz,et al.  A genetically encoded fluorescent probe in mammalian cells. , 2013, Journal of the American Chemical Society.

[23]  R. Blunck,et al.  Dynamics of internal pore opening in KV channels probed by a fluorescent unnatural amino acid , 2013, Proceedings of the National Academy of Sciences.

[24]  G. Yellen,et al.  Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate , 2012, The Journal of general physiology.

[25]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[26]  Gunnar Jeschke,et al.  DEER distance measurements on proteins. , 2012, Annual review of physical chemistry.

[27]  J. Morais-Cabral,et al.  310 helices in channels and other membrane proteins , 2010, The Journal of general physiology.

[28]  Xiao Tao,et al.  A Gating Charge Transfer Center in Voltage Sensors , 2010, Science.

[29]  W. N. Zagotta,et al.  Short-distance probes for protein backbone structure based on energy transfer between bimane and transition metal ions , 2009, Proceedings of the National Academy of Sciences.

[30]  C. Wahl-Schott,et al.  Hyperpolarization-activated cation channels: from genes to function. , 2009, Physiological reviews.

[31]  W. N. Zagotta,et al.  Mapping the structure and conformational movements of proteins with transition metal ion FRET , 2009, Nature Methods.

[32]  E. Campbell,et al.  Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment , 2007, Nature.

[33]  A. Bruening-Wright,et al.  Kinetic Relationship between the Voltage Sensor and the Activation Gate in spHCN Channels , 2007, The Journal of general physiology.

[34]  S. Siegelbaum,et al.  Modulation of cyclic nucleotide-regulated HCN channels by PIP2 and receptors coupled to phospholipase C , 2007, Pflügers Archiv - European Journal of Physiology.

[35]  Banumathi Sankaran,et al.  Structure and rearrangements in the carboxy-terminal region of SpIH channels. , 2007, Structure.

[36]  W. N. Zagotta,et al.  CNG and HCN channels: two peas, one pod. , 2006, Annual review of physiology.

[37]  F. Bezanilla,et al.  Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer , 2005, Nature.

[38]  Francisco Bezanilla,et al.  Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement , 2005, Nature.

[39]  E. Campbell,et al.  Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling , 2005, Science.

[40]  Brad S Rothberg,et al.  Inactivation in HCN Channels Results from Reclosure of the Activation Gate Desensitization to Voltage , 2004, Neuron.

[41]  S. Siegelbaum,et al.  Changes in Local S4 Environment Provide a Voltage-sensing Mechanism for Mammalian Hyperpolarization–activated HCN Channels , 2004, The Journal of general physiology.

[42]  H. Larsson,et al.  S4 Movement in a Mammalian HCN Channel , 2004, The Journal of general physiology.

[43]  Jie Zheng,et al.  Patch-Clamp Fluorometry Recording of Conformational Rearrangements of Ion Channels , 2003, Science's STKE.

[44]  F. Elinder,et al.  Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages , 2002, Nature.

[45]  B. Hille,et al.  Ionic channels of excitable membranes , 2001 .

[46]  Francisco Bezanilla,et al.  Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy , 1999, Nature.

[47]  E. Isacoff,et al.  Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel , 1999, Nature.

[48]  M. Biel,et al.  A family of hyperpolarization-activated mammalian cation channels , 1998, Nature.

[49]  U. Kaupp,et al.  Molecular identification of a hyperpolarization-activated channel in sea urchin sperm , 1998, Nature.

[50]  Eric R Kandel,et al.  Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain , 1998, Cell.

[51]  Bertil Hille,et al.  Voltage-Gated Ion Channels and Electrical Excitability , 1998, Neuron.

[52]  Ehud Y. Isacoff,et al.  Transmembrane Movement of the Shaker K+ Channel S4 , 1996, Neuron.

[53]  W. N. Zagotta,et al.  Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels , 1995, Neuron.

[54]  R. Horn,et al.  Evidence for voltage-dependent S4 movement in sodium channels , 1995, Neuron.

[55]  Y. Jan,et al.  Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence , 1991, Nature.

[56]  F. Conti,et al.  Structural parts involved in activation and inactivation of the sodium channel , 1989, Nature.

[57]  Dario DiFrancesco,et al.  Characterization of single pacemaker channels in cardiac sino-atrial node cells , 1986, Nature.

[58]  G. Jeschke,et al.  Prediction of favourable sites for spin labelling of proteins , 2010 .

[59]  David Baker,et al.  Protein Structure Prediction Using Rosetta , 2004, Numerical Computer Methods, Part D.

[60]  Paul R Selvin,et al.  Principles and biophysical applications of lanthanide-based probes. , 2002, Annual review of biophysics and biomolecular structure.

[61]  L. Stryer.  Fluorescence energy transfer as a spectroscopic ruler. , 1978, Annual review of biochemistry.

[62]  M. Kodama,et al.  Equilibria and kinetics of complex formation between zinc(II), lead(II), and cadmium(II), and 12-, 13-, 14-, and 15-membered macrocyclic tetra-amines , 1977 .

[63]  J. Morais-Cabral,et al.  helices in channels and other membrane proteins , 2022 .