Technique development of 3D dynamic CS‐EPSI for hyperpolarized 13C pyruvate MR molecular imaging of human prostate cancer

The purpose of this study was to develop a new 3D dynamic carbon‐13 compressed sensing echoplanar spectroscopic imaging (EPSI) MR sequence and test it in phantoms, animal models, and then in prostate cancer patients to image the metabolic conversion of hyperpolarized [1‐13C]pyruvate to [1‐13C]lactate with whole gland coverage at high spatial and temporal resolution.

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