Analysis, fate and effects of the antibiotic sulfadiazine in soil ecosystems

This review summarizes current knowledge about the interplay between fate and effects of the antibiotic sulfadiazine in soil ecosystems. In applying manure from antibiotic-treated animals to arable soils, sulfadiazine can reach the environment, but fate and transformation processes and the consequences for soil microorganisms and soil functions have not been studied adequately. Since antibiotics are explicitly designed to affect microorganisms, they are likely to affect “non-target” microbes in the soil ecosystem. Recent papers provide new insights into the disappearance dynamics of sulfadiazine, its effects on distinct microbial communities and the development of antibiotic resistance.

[1]  H. Heuer,et al.  Manure and sulfadiazine synergistically increased bacterial antibiotic resistance in soil over at least two months. , 2007, Environmental microbiology.

[2]  A. Focks,et al.  Fate of sulfadiazine administered to pigs and its quantitative effect on the dynamics of bacterial resistance genes in manure and manured soil , 2008 .

[3]  C. Stamm,et al.  Exhaustive extraction of sulfonamide antibiotics from aged agricultural soils using pressurized liquid extraction. , 2006, Journal of chromatography. A.

[4]  S. Schrader,et al.  Chemical and biological characterization of non-extractable sulfonamide residues in soil. , 2006, Chemosphere.

[5]  H. Heuer,et al.  Impact of the antibiotic sulfadiazine and pig manure on the microbial community structure in agricultural soils , 2008 .

[6]  S. Jørgensen,et al.  Algal Toxicity of Antibacterial Agents Applied in Danish Fish Farming , 1999, Archives of environmental contamination and toxicology.

[7]  Bent Halling-Sørensen,et al.  Biodegradability properties of sulfonamides in activated sludge , 2000 .

[8]  Kornelia Smalla,et al.  Exogenous Isolation of Antibiotic Resistance Plasmids from Piggery Manure Slurries Reveals a High Prevalence and Diversity of IncQ-Like Plasmids , 2000, Applied and Environmental Microbiology.

[9]  G. K. Elmund,et al.  Role of excreted chlortetracycline in modifying the decomposition process in feedlot waste , 1971, Bulletin of environmental contamination and toxicology.

[10]  J. Tarazona,et al.  Effect Assessment of Antimicrobial Pharmaceuticals on the Aquatic Plant Lemna minor , 2003, Bulletin of environmental contamination and toxicology.

[11]  R. Kreuzig,et al.  Investigations on the fate of sulfadiazine in manured soil: Laboratory experiments and test plot studies , 2005, Environmental toxicology and chemistry.

[12]  S. Thiele-Bruhn,et al.  Effects of sulfonamide and tetracycline antibiotics on soil microbial activity and microbial biomass. , 2005, Chemosphere.

[13]  Juan Gao,et al.  Adsorption of sulfonamide antimicrobial agents to clay minerals. , 2005, Environmental science & technology.

[14]  M. Schloter,et al.  Dynamics and functional relevance of ammonia-oxidizing archaea in two agricultural soils. , 2009, Environmental microbiology.

[15]  L. Dijkshoorn,et al.  An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii , 2007, Nature Reviews Microbiology.

[16]  H. Heuer,et al.  Gentamicin resistance genes in environmental bacteria: prevalence and transfer. , 2002, FEMS microbiology ecology.

[17]  J. Tolls,et al.  The effect of pH and ionic strength on the sorption of sulfachloropyridazine, tylosin, and oxytetracycline to soil , 2006, Environmental toxicology and chemistry.

[18]  Sören Thiele-Bruhn,et al.  Pharmaceutical antibiotic compounds in soils – a review , 2003 .

[19]  A. Boxall,et al.  Are veterinary medicines causing environmental risks? , 2003, Environmental science & technology.

[20]  K. Jones,et al.  Assessment of organic contanhnant fate in waste water treatment plants I: Selected compounds and physicochemical properties , 1999 .

[21]  A. Boxall,et al.  A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. , 2006, Chemosphere.

[22]  Jaap Bloem,et al.  Effects of tylosin as a disturbance on the soil microbial community , 2001 .

[23]  T. Urich,et al.  Archaea predominate among ammonia-oxidizing prokaryotes in soils , 2006, Nature.

[24]  M. Alexander,et al.  Aging, bioavailability, and overestimation of risk from environmental pollutants , 2000 .

[25]  C. Adams,et al.  Effects of sorbate speciation on sorption of selected sulfonamides in three loamy soils. , 2007, Journal of agricultural and food chemistry.

[26]  C. Stamm,et al.  Surface runoff and transport of sulfonamide antibiotics and tracers on manured grassland. , 2005, Journal of environmental quality.

[27]  T. Pütz,et al.  Analysis of aged sulfadiazine residues in soils using microwave extraction and liquid chromatography tandem mass spectrometry , 2008, Analytical and bioanalytical chemistry.

[28]  A. Pollio,et al.  Environmental risk assessment of six human pharmaceuticals: Are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment? , 2004, Environmental toxicology and chemistry.

[29]  H. Vereecken,et al.  Impact of sulfadiazine and chlorotetracycline on soil bacterial community structure and respiratory activity , 2006 .

[30]  J. Pignatello Slowly reversible sorption of aliphatic halocarbons in soils. II. Mechanistic aspects , 1990 .

[31]  T. O'Brien Emergence, spread, and environmental effect of antimicrobial resistance: how use of an antimicrobial anywhere can increase resistance to any antimicrobial anywhere else. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[32]  Richard A Brain,et al.  Herbicidal effects of sulfamethoxazole in Lemna gibba: using p-aminobenzoic acid as a biomarker of effect. , 2008, Environmental science & technology.

[33]  A. Schäffer,et al.  Fate in soil of 14C-sulfadiazine residues contained in the manure of young pigs treated with a veterinary antibiotic , 2008, Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.

[34]  H. Nau,et al.  Different behavior of tetracyclines and sulfonamides in sandy soils after repeated fertilization with liquid manure , 2005, Environmental toxicology and chemistry.

[35]  M. Spiteller,et al.  Metabolism of 14C-labelled and non-labelled sulfadiazine after administration to pigs , 2007, Analytical and bioanalytical chemistry.

[36]  A. Summers Generally overlooked fundamentals of bacterial genetics and ecology. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[37]  M. Matthies,et al.  A mechanistical model for the uptake of sulfonamides by bacteria. , 2008, Chemosphere.

[38]  Christa S. McArdell,et al.  Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. , 2002, Journal of chromatography. A.

[39]  Sören Thiele-Bruhn,et al.  Alterations in soil microbial activity and N-transformation processes due to sulfadiazine loads in pig-manure. , 2008, Environmental pollution.

[40]  A. Pühler,et al.  The complete sequences of plasmids pB2 and pB3 provide evidence for a recent ancestor of the IncP-1beta group without any accessory genes. , 2004, Microbiology.

[41]  Heike Schmitt,et al.  Effects of antibiotics on soil microorganisms: time and nutrients influence pollution-induced community tolerance , 2005 .

[42]  B. Halling‐Sørensen,et al.  Inhibition of Aerobic Growth and Nitrification of Bacteria in Sewage Sludge by Antibacterial Agents , 2001, Archives of environmental contamination and toxicology.

[43]  G. Brown,et al.  The biosynthesis of folic acid. II. Inhibition by sulfonamides. , 1962, The Journal of biological chemistry.

[44]  T. Vree,et al.  In vitro effects of sulfadiazine and its metabolites alone and in combination with pyrimethamine on Toxoplasma gondii , 1995, Antimicrobial Agents and Chemotherapy.

[45]  V. Perreten,et al.  A New Sulfonamide Resistance Gene (sul3) in Escherichia coli Is Widespread in the Pig Population of Switzerland , 2003, Antimicrobial Agents and Chemotherapy.

[46]  J. Bailar,et al.  Review of assessments of the human health risk associated with the use of antimicrobial agents in agriculture. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[47]  K. Smalla,et al.  Manure Enhances Plasmid Mobilization and Survival of Pseudomonas putida Introduced into Field Soil , 1997, Applied and environmental microbiology.

[48]  R. Brain,et al.  Effects of 25 pharmaceutical compounds to Lemna gibba using a seven‐day static‐renewal test , 2004, Environmental toxicology and chemistry.

[49]  H. Heuer,et al.  Piggery manure used for soil fertilization is a reservoir for transferable antibiotic resistance plasmids. , 2008, FEMS microbiology ecology.

[50]  H. Nau,et al.  Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. , 2002, Analytical chemistry.

[51]  Ola Sköld,et al.  Sulfonamide resistance: mechanisms and trends. , 2000, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[52]  C. Stamm,et al.  Time and pH-dependent sorption of the veterinary antimicrobial sulfathiazole to clay minerals and ferrihydrite. , 2007, Chemosphere.

[53]  J. Gregory,et al.  Folate Synthesis and Metabolism in Plants and Prospects For Biofortification , 2005 .

[54]  J. Pedersen,et al.  NMR investigation of enzymatic coupling of sulfonamide antimicrobials with humic substances. , 2008, Environmental science & technology.

[55]  Carlos Fernández,et al.  Effects of sulfachlorpyridazine in MS·3‐arable land: A multispecies soil system for assessing the environmental fate and effects of veterinary medicines , 2005, Environmental toxicology and chemistry.

[56]  C. van Leeuwen,et al.  Pollution-induced community tolerance of soil microbial communities caused by the antibiotic sulfachloropyridazine. , 2004, Environmental science & technology.

[57]  L. Migliore,et al.  Laboratory models to evaluate phytotoxicity of sulphadimethoxine on terrestrial plants , 1998 .