Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy
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[1] E. Pravatà,et al. Reply , 2001, British Journal of Cancer.
[2] M Heath-Chiozzi,et al. Clinical application of pharmacogenetics. , 2001, Trends in molecular medicine.
[3] Pui-Yan Kwok,et al. Single-nucleotide polymorphisms in the public domain: how useful are they? , 2001, Nature Genetics.
[4] N. Freimer,et al. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes , 2001, Nature Genetics.
[5] Ann Daly,et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression , 2001, Nature Genetics.
[6] R. Weinshilboum,et al. Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[7] C. Meisel,et al. Frequency of single nucleotide polymorphisms in the P‐glycoprotein drug transporter MDR1 gene in white subjects , 2001, Clinical pharmacology and therapeutics.
[8] D. Filliol,et al. A Single Nucleotide Polymorphic Mutation in the Human μ-Opioid Receptor Severely Impairs Receptor Signaling* , 2001, The Journal of Biological Chemistry.
[9] M. Oscarson. Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[10] U. Meyer. Pharmacogenetics and adverse drug reactions , 2000, The Lancet.
[11] A. Kjellin,et al. Omeprazole and CYP2C19 polymorphism: effects of long‐term treatment on gastrin, pepsinogen I, and chromogranin A in patients with acid related disorders , 2000, Alimentary pharmacology & therapeutics.
[12] M. Pirmohamed,et al. Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study , 2000, Journal of clinical pharmacy and therapeutics.
[13] R. Tyndale,et al. Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking. , 2000, Molecular pharmacology.
[14] D M Roden,et al. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[15] R S Judson,et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[16] W. Evans,et al. Genetic Polymorphism of Thiopurine S-Methyltransferase: Molecular Mechanisms and Clinical Importance , 2000, Pharmacology.
[17] Y. Wing,et al. Occurrence of CYP2D6 gene duplication in Hong Kong Chinese. , 2000, Clinical chemistry.
[18] S. Liggett. Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors , 2000, Pharmacology.
[19] T. Baglin,et al. Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. , 2000, Blood.
[20] M. Kool,et al. A family of drug transporters: the multidrug resistance-associated proteins. , 2000, Journal of the National Cancer Institute.
[21] S. Imaoka,et al. The decreased in vivo clearance of CYP2D6 substrates by CYP2D6*10 might be caused not only by the low-expression but also by low affinity of CYP2D6. , 2000, Archives of biochemistry and biophysics.
[22] J. Azuma,et al. CYP2D6 genotypes in a Japanese population: low frequencies of CYP2D6 gene duplication but high frequency of CYP2D6*10. , 2000, Pharmacogenetics.
[23] R. Tyndale,et al. Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking , 2000, Clinical pharmacology and therapeutics.
[24] A. Roses. Pharmacogenetics and the practice of medicine , 2000, Nature.
[25] C. Heyser,et al. mu-Opioid receptor knockout mice do not self-administer alcohol. , 2000, The Journal of pharmacology and experimental therapeutics.
[26] I. Leclercq,et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. , 2000, The Journal of clinical investigation.
[27] H. Sugimura,et al. Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. , 2000, Clinical pharmacology and therapeutics.
[28] U. Brinkmann,et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[29] L. Bertilsson,et al. Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes. , 2000, British journal of clinical pharmacology.
[30] M. Ingelman-Sundberg,et al. Duplication, multiduplication, and amplification of genes encoding drug-metabolizing enzymes: evolutionary, toxicological, and clinical pharmacological aspects. , 1999, Drug metabolism reviews.
[31] L. Bertilsson,et al. Disposition of debrisoquine in Caucasians with different CYP2D6-genotypes including those with multiple genes. , 1999, Pharmacogenetics.
[32] M. Relling,et al. Pharmacogenomics: translating functional genomics into rational therapeutics. , 1999, Science.
[33] M. Ingelman-Sundberg,et al. Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine. , 1999, Pharmacogenetics.
[34] M. Ingelman-Sundberg,et al. Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment. , 1999, Trends in pharmacological sciences.
[35] Nicholas Schork,et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment , 1999, Nature Genetics.
[36] M. Keating,et al. MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia , 1999, Cell.
[37] G. Aithal,et al. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications , 1999, The Lancet.
[38] R. Hauer,et al. Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management , 2022 .
[39] P. Tu,et al. No evidence for association of serotonin-2A receptor variant (102T/C) with schizophrenia or clozapine response in a Chinese population. , 1999, Neuroreport.
[40] P. Padfield,et al. Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure. , 1998, Journal of cardiovascular pharmacology.
[41] M. Ratain,et al. Pharmacogenetics and cancer chemotherapy. , 1998, European journal of cancer.
[42] J. Miners,et al. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. , 1998, British journal of clinical pharmacology.
[43] L. Bertilsson,et al. 10‐hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes , 1998, Clinical pharmacology and therapeutics.
[44] J W Jukema,et al. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. , 1998, The New England journal of medicine.
[45] M. Ingelman-Sundberg,et al. Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity. , 1997, Molecular pharmacology.
[46] M. Dahl,et al. Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine. , 1997, Therapeutic drug monitoring.
[47] M Ingelman-Sundberg,et al. Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians. , 1997, Pharmacogenetics.
[48] D. Clapham,et al. Ion channels--basic science and clinical disease. , 1997, The New England journal of medicine.
[49] D. Classen,et al. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. , 1997, JAMA.
[50] F. Cambien,et al. Influence of the angiotensin II type 1 receptor gene polymorphism on the effects of perindopril and nitrendipine on arterial stiffness in hypertensive individuals. , 1996, Hypertension.
[51] D. Collier,et al. Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine , 1996, Neuroscience Letters.
[52] M. Kreek. Opiates, opioids and addiction. , 1996, Molecular psychiatry.
[53] H. Scheffer,et al. Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy , 1996, The Lancet.
[54] S. Gauthier,et al. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[55] I. Ichikawa,et al. Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. , 1995, The Journal of clinical investigation.
[56] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[57] P Corvol,et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. , 1990, The Journal of clinical investigation.
[58] C. Alm,et al. Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in luman beings , 1989, Clinical pharmacology and therapeutics.
[59] U. Meyer,et al. MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. , 1987, Biochemical and biophysical research communications.
[60] D. Collier,et al. Pharmacogenetics for the Individualization of Psychiatric Treatment , 2001, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.
[61] N. Malats,et al. Why study metabolic susceptibility to cancer? , 1999, IARC scientific publications.
[62] A. Marshall. Getting the right drug into the right patient , 1998, Nature Biotechnology.
[63] J Drews,et al. The role of innovation in drug development. , 1997, Nature biotechnology.