Fermentative Biohydrogen Modelling and Optimization Research in Light of Miniaturized Parallel Bioreactors

ABSTRACT In the last decade, there has been an upsurge of interest to make a transition from the depleting fossil-based energy sources to renewable ones. Fermentative biohydrogen has been repeatedly flagged as a potential future alternative energy carrier in recent publications. Research towards its scale-up requires accurate and high throughput optimization data on key process parameters. This has been hampered by conflicting findings, potentially owing to research procedures and bioreactor equipments used. This paper reviews the current state of fermentative biohydrogen optimization research on agricultural wastes, using miniaturized parallel bioreactors (MPBs). The monitoring and control of physicochemical parameters on these bioreactors is discussed and the prospect of enhancing biohydrogen process development with a novel featured parallel miniaturized bioreactor is presented.

[1]  F. Wurm,et al.  Small-scale bioreactor system for process development and optimization. , 2001, Biochemical engineering journal.

[2]  Qiang Liu,et al.  Optimization of fermentative biohydrogen production by response surface methodology using fresh leachate as nutrient supplement. , 2011, Bioresource technology.

[3]  F. Meng,et al.  Effect of hydraulic retention time on membrane fouling and biomass characteristics in submerged membrane bioreactors , 2007, Bioprocess and biosystems engineering.

[4]  Bo Jin,et al.  Process optimization of biological hydrogen production from molasses by a newly isolated Clostridium butyricum W5. , 2009, Journal of bioscience and bioengineering.

[5]  Heguang Zhu,et al.  Evaluation of alternative methods of preparing hydrogen producing seeds from digested wastewater sludge , 2006 .

[6]  J. Teixeira,et al.  Proof‐of‐concept of a novel micro‐bioreactor for fast development of industrial bioprocesses , 2006, Biotechnology and bioengineering.

[7]  Jo-Shu Chang,et al.  Cellulosic hydrogen production with a sequencing bacterial hydrolysis and dark fermentation strategy. , 2008, Bioresource technology.

[8]  Michael J. Gramer,et al.  Comparison of cell growth in T-flasks, in micro hollow fiber bioreactors, and in an industrial scale hollow fiber bioreactor system , 2000, Cytotechnology.

[9]  Jay D Keasling,et al.  Microbioreactor arrays with parametric control for high‐throughput experimentation , 2004, Biotechnology and bioengineering.

[10]  Joo-Hwa Tay,et al.  Production of hydrogen in a granular sludge-based anaerobic continuous stirred tank reactor , 2007 .

[11]  H. Argun,et al.  Biohydrogen production by dark fermentation of wheat powder solution: Effects of C/N and C/P ratio on hydrogen yield and formation rate , 2008 .

[12]  Debabrata Das,et al.  RECENT DEVELOPMENTS IN BIOLOGICAL HYDROGEN PRODUCTION PROCESSES , 2008 .

[13]  N. Ren,et al.  Continuous hydrogen production of auto-aggregative Ethanoligenens harbinense YUAN-3 under non-sterile condition , 2008 .

[14]  Luis Manuel Rosales-Colunga,et al.  Estimation of hydrogen production in genetically modified E. coli fermentations using an artificial neural network , 2010 .

[15]  Zhengxiao Guo,et al.  Artificial neural network modelling of hydrogen storage properties of Mg-based alloys , 2004 .

[16]  J. Büchs,et al.  Device for sterile online measurement of the oxygen transfer rate in shaking flasks. , 2001, Biochemical engineering journal.

[17]  Dirk Weuster-Botz,et al.  Miniature bioreactors for automated high‐throughput bioprocess design (HTBD): reproducibility of parallel fed‐batch cultivations with Escherichia coli , 2005, Biotechnology and applied biochemistry.

[18]  You-Kwan Oh,et al.  Fermentative biohydrogen production by a new chemoheterotrophic bacterium Citrobacter sp. Y19 , 2003 .

[19]  Chin-Chao Chen,et al.  Thermophilic dark fermentation of untreated rice straw using mixed cultures for hydrogen production , 2012 .

[20]  J. Auniņš,et al.  Large-scale mammalian cell culture. , 1997, Current opinion in biotechnology.

[21]  Nicolas Szita,et al.  A well‐mixed, polymer‐based microbioreactor with integrated optical measurements , 2006, Biotechnology and bioengineering.

[22]  I. Eroglu,et al.  Hydrogen gas production by combined systems of Rhodobacter sphaeroides O.U.001 and Halobacterium salinarum in a photobioreactor , 2006 .

[23]  Han-Qing Yu,et al.  Simulation of biological hydrogen production in a UASB reactor using neural network and genetic algorithm , 2007 .

[24]  Bea-Ven Chang,et al.  Using filtrate of waste biosolids to effectively produce bio-hydrogen by anaerobic fermentation. , 2003, Water research.

[25]  Dae Sung Lee,et al.  Prediction of Biological Hydrogen Production in a Packed-Bed Bioreactor Using a Genetically Evolved Artificial Neural Network , 2011 .

[26]  F. Kargı,et al.  Bio-hydrogen production from waste materials , 2006 .

[27]  Zhong Fang,et al.  Effects of sludge pretreatments and organic acids on hydrogen production by anaerobic fermentation. , 2010, Bioresource technology.

[28]  Debabrata Das,et al.  Biohydrogen as a renewable energy resource—Prospects and potentials , 2008 .

[29]  B Allen,et al.  Design of a prototype miniature bioreactor for high throughput automated bioprocessing , 2003 .

[30]  Jie Ding,et al.  Biohydrogen production from ethanol-type fermentation of molasses in an expanded granular sludge bed (EGSB) reactor , 2008 .

[31]  C. Pan,et al.  Bioconversion of corncob to hydrogen using anaerobic mixed microflora , 2010 .

[32]  J. S. Hunter,et al.  Statistics for experimenters : an introduction to design, data analysis, and model building , 1979 .

[33]  Shih-Chi Lee,et al.  Co-fermentation of water hyacinth and beverage wastewater in powder and pellet form for hydrogen production. , 2013, Bioresource technology.

[34]  Chin-Chao Chen,et al.  Acid–base enrichment enhances anaerobic hydrogen production process , 2001, Applied Microbiology and Biotechnology.

[35]  Yuansong Wei,et al.  Enhanced biohydrogen production from sewage sludge with alkaline pretreatment. , 2004, Environmental science & technology.

[36]  T. Swanson,et al.  Development and Field Confirmation of a Mathematical Model for Amyloglucosidase/Pullulanase Saccharification , 1986 .

[37]  Rachel Legmann,et al.  A predictive high‐throughput scale‐down model of monoclonal antibody production in CHO cells , 2009, Biotechnology and bioengineering.

[38]  S Venkata Mohan,et al.  Biohydrogen production from chemical wastewater treatment in biofilm configured reactor operated in periodic discontinuous batch mode by selectively enriched anaerobic mixed consortia. , 2007, Water research.

[39]  Ashraf Amanullah,et al.  Twenty‐four‐well plate miniature bioreactor high‐throughput system: Assessment for microbial cultivations , 2007, Biotechnology and bioengineering.

[40]  Jonathan I. Betts,et al.  Miniature bioreactors: current practices and future opportunities , 2006, Microbial cell factories.

[41]  Gustavo Davila-Vazquez,et al.  Fermentative hydrogen production in batch experiments using lactose, cheese whey and glucose: Influence of initial substrate concentration and pH , 2008 .

[42]  U. Bach,et al.  Comment on \"Measurement of Ultrafast Photoinduced Electron Transfer from Chemically Anchored Ru-Dye Molecules into Empty Electronic States in a Colloidal Anatase TiO2 Film\" , 1998 .

[43]  Patrick Vermette,et al.  Bioreactors for tissue mass culture: design, characterization, and recent advances. , 2005, Biomaterials.

[44]  Zhang Jing-nan,et al.  Enhanced bio-hydrogen production from corn stalk by anaerobic fermentation using response surface me , 2011 .

[45]  M. Inui,et al.  Enhanced hydrogen production from glucose using ldh- and frd-inactivated Escherichiacoli strains , 2006, Applied Microbiology and Biotechnology.

[46]  P. Hallenbeck,et al.  Optimization of the hydrogen yield from single-stage photofermentation of glucose by Rhodobacter capsulatus JP91 using response surface methodology. , 2012, Bioresource technology.

[47]  G. Nakhla,et al.  The effect of heat pretreatment temperature on fermentative hydrogen production using mixed cultures , 2008 .

[48]  G. Mtui.  Recent advances in pretreatment of lignocellulosic wastes and production of value added products , 2009 .

[49]  A. R. Zinsmeister,et al.  Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building, by G. E. P. Box, W. G. Hunter, and J. S. Hunter , 1981 .

[50]  Haijun Yang,et al.  Continuous bio-hydrogen production from citric acid wastewater via facultative anaerobic bacteria , 2006 .

[51]  T. Nejat Veziroglu,et al.  “Green” path from fossil-based to hydrogen economy: An overview of carbon-neutral technologies , 2008 .

[52]  J. Lay,et al.  Biohydrogen production as a function of pH and substrate concentration. , 2001, Environmental science & technology.

[53]  S. Kuwae,et al.  Development of a fed-batch culture process for enhanced production of recombinant human antithrombin by Chinese hamster ovary cells. , 2005, Journal of bioscience and bioengineering.

[54]  Jie Ding,et al.  Optimization of culture conditions for hydrogen production by Ethanoligenens harbinense B49 using response surface methodology. , 2009, Bioresource technology.

[55]  Annick Wilmotte,et al.  Fermentative hydrogen production from glucose and starch using pure strains and artificial co-cultures ofClostridium spp. , 2012, Biotechnology for Biofuels.

[56]  J. Lay,et al.  Biohydrogen generation by mesophilic anaerobic fermentation of microcrystalline cellulose. , 2001, Biotechnology and bioengineering.

[57]  Zhiyu Zhang,et al.  Microbioreactors for Bioprocess Development , 2007 .

[58]  W. Nakatsukasa,et al.  Response surface methods for optimizingSaccharopolyspora spinosa, a novel macrolide producer , 1993, Journal of Industrial Microbiology.

[59]  Poonsuk Prasertsan,et al.  Optimization of simultaneous thermophilic fermentative hydrogen production and COD reduction from palm oil mill effluent by Thermoanaerobacterium-rich sludge , 2008 .

[60]  Jianlong Wang,et al.  FACTORS INFLUENCING FERMENTATIVE HYDROGEN PRODUCTION: A REVIEW , 2009 .

[61]  E. Mcpherson,et al.  Urban ecosystems and the North American carbon cycle , 2006 .

[62]  Irini Angelidaki,et al.  Biohydrogen production from xylose at extreme thermophilic temperatures (70 degrees C) by mixed culture fermentation. , 2009, Water research.

[63]  Dae Sung Lee,et al.  Biological hydrogen production by immobilized cells of Clostridium tyrobutyricum JM1 isolated from a food waste treatment process. , 2008, Bioresource technology.

[64]  An Overview of Factors Influencing the Enzymatic Hydrolysis of Lignocellulosic Feedstocks , 2000 .

[65]  J. Büchs,et al.  Online monitoring in continuously shaken microtiter plates for scalable upstream bioprocessing , 2011 .

[66]  J. Lay,et al.  Feasibility of biological hydrogen production from organic fraction of municipal solid waste , 1999 .

[67]  Tong Zhang,et al.  Acidophilic biohydrogen production from rice slurry , 2006 .

[68]  Chiu-Yue Lin,et al.  A nutrient formulation for fermentative hydrogen production using anaerobic sewage sludge microflora , 2005 .

[69]  Yanling He,et al.  High hydrogen yield from a two-step process of dark- and photo-fermentation of sucrose , 2007 .

[70]  C. Thomas,et al.  Inoculum effects on fungal morphology: Shake flasks vs agitated bioreactors , 1994 .

[71]  A. Tefferi,et al.  Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms , 2008, Leukemia.

[72]  P. N. Sarma,et al.  Acidogenic fermentation of vegetable based market waste to harness biohydrogen with simultaneous stabilization. , 2009, Bioresource technology.

[73]  Peng Zhang,et al.  Efficient hydrogen gas production from cassava and food waste by a two-step process of dark fermentation and photo-fermentation , 2009 .

[74]  Oxygen limitation is a pitfall during screening for industrial strains , 2006, Applied Microbiology and Biotechnology.

[75]  M. Barton,et al.  MicroRNA binding sites in Arabidopsis class III HD-ZIP mRNAs are required for methylation of the template chromosome. , 2004, Developmental cell.

[76]  H. Argun,et al.  Optimization of media composition for hydrogen gas production from hydrolyzed wheat starch by dark fermentation , 2008 .

[77]  Hang-Sik Shin,et al.  FEASIBILITY OF BIOHYDROGEN PRODUCTION BY ANAEROBIC CO-DIGESTION OF FOOD WASTE AND SEWAGE SLUDGE , 2004 .

[78]  G. Rao,et al.  Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors , 2009, Microbial cell factories.

[79]  M. Azuma,et al.  Production of hydrogen by a hydrogenase-deficient mutant of Rhodobacter capsulatus , 1998 .

[80]  Anish Kumar,et al.  Hydrogen production by Rhodobacter sphaeroides strain O.U.001 using spent media of Enterobacter cloacae strain DM11 , 2005, Applied Microbiology and Biotechnology.

[81]  J. Cabral,et al.  Design and characterisation of an enzyme system for inulin hydrolysis , 2006 .

[82]  David Pollard,et al.  A review of advanced small‐scale parallel bioreactor technology for accelerated process development: Current state and future need , 2011, Biotechnology progress.

[83]  Jasvinder Singh,et al.  Commercialization potential of microalgae for biofuels production , 2010 .