Blood flow in distal end-to-side anastomoses with PTFE and a venous patch: results of an in vitro flow visualisation study.

OBJECTIVES non-physiological flow behaviour plays a significant role in the development of distal anastomotic intimal hyperplasia. To investigate flow patterns in four anastomotic types of femoral end-to-side distal bypass graft anastomoses, a flow visualisation study was performed. METHODS transparent 1:1 casted replicas of distal vascular graft anastomoses created by conventional technique, Miller-cuff, Taylor- and Linton-patch were fabricated. A pulsatile mock circulation with a high-speed video system was constructed. Flow pattern was determined at mean Reynolds numbers 100-500. Migrations of the stagnation points on the bottom of the anastomoses at mean Reynolds numbers 100, 230, and 350 were measured. RESULTS a vortex forms during early systole and increases to maximum systole in all anastomoses. During the diastolic phase the vortex moves in the Miller-cuff distally to the toe of the anastomosis and remains standing, while in the other anastomotic types the vortex moves proximally to the heal of the junction and breaks down. The shift of the stagnation point in the Miller-cuff was considerably smaller than in the other anastomoses. CONCLUSION conventional, Linton and Taylor anastomoses show similar flow patterns. The Miller-cuff with its wider cavity shows lower shift of the bottom stagnation point, but a persistent washout of the anastomotic cavity, which may contribute to its reported good clinical performance.

[1]  ROBERT M. NEREM,et al.  Velocity Distribution and Intimal Proliferation in Autologous Vein Grafts in Dogs , 1978, Circulation research.

[2]  J. Miller,et al.  Interposition vein cuff for anastomosis of prosthesis to small artery. , 1984, The Australian and New Zealand journal of surgery.

[3]  S Glagov,et al.  Anastomotic intimal hyperplasia: mechanical injury or flow induced. , 1992, Journal of vascular surgery.

[4]  C. R. Ethier,et al.  Steady and pulsatile flow fields in an end-to-side arterial anastomosis model. , 1990, Journal of vascular surgery.

[5]  V. Sottiurai,et al.  Linton patch angioplasty. An adjunct to distal bypass with polytetrafluoroethylene grafts. , 1984, Annals of surgery.

[6]  Hemodynamics of a side-to-end proximal arterial anastomosis model. , 1993, Journal of vascular surgery.

[7]  P. Harris,et al.  Stable vortices within vein cuffs inhibit anastomotic myointimal hyperplasia? , 1997, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[8]  K. Perktold,et al.  Flow dynamic effect of the anastomotic angle: a numerical study of pulsatile flow in vascular graft anastomoses models. , 1994, Technology and health care : official journal of the European Society for Engineering and Medicine.

[9]  A. Moritz,et al.  Compliance and formation of distal anastomotic intimal hyperplasia in Dacron mesh tube constricted veins used as arterial bypass grafts. , 1994, ASAIO journal.

[10]  R. Taylor,et al.  An investigation into the causes of failure of PTFE grafts. , 1987, European journal of vascular surgery.

[11]  F. Logerfo,et al.  Boundary layer separation in models of side-to-end arterial anastomoses. , 1979, Archives of surgery.

[12]  J. Wolfe,et al.  PTFE, collars, and patches. , 1992, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[13]  R S Cobbold,et al.  Influence of angle on wall shear stress distribution for an end-to-side anastomosis. , 1994, Journal of vascular surgery.

[14]  J. Wolfe,et al.  Is arterial reconstruction to the ankle worthwhile in the absence of autologous vein? , 1989, European journal of vascular surgery.

[15]  V. Sottiurai,et al.  Distal anastomotic intimal hyperplasia: histopathologic character and biogenesis. , 1989, Annals of vascular surgery.

[16]  K Affeld,et al.  Fluid mechanics of the stagnation point flow chamber and its platelet deposition. , 1995, Artificial organs.

[17]  A. Loh,et al.  PTFE bypass grafting to isolated popliteal segments in critical limb ischaemia. , 1993, European journal of vascular surgery.

[18]  H. Schima,et al.  Numerical study of wall mechanics and fluid dynamics in end-to-side anastomoses and correlation to intimal hyperplasia. , 1996, Journal of biomechanics.

[19]  A. Imparato,et al.  Intimal and neointimal fibrous proliferation causing failure of arterial reconstructions. , 1972, Surgery.

[20]  D. Steinman,et al.  A numerical simulation of flow in a two-dimensional end-to-side anastomosis model. , 1993, Journal of biomechanical engineering.

[21]  V. Bernhard,et al.  Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions. , 1986, Journal of vascular surgery.

[22]  U Losert,et al.  Compliance mismatch and formation of distal anastomotic intimal hyperplasia in externally stiffened and lumen-adapted venous grafts. , 1995, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[23]  W. Quist,et al.  Flow disturbance at the distal end-to-side anastomosis. Effect of patency of the proximal outflow segment and angle of anastomosis. , 1980, Archives of surgery.

[24]  Cheshire Nj,et al.  How to select the treatment of choice in critical leg ischaemia. , 1992 .

[25]  J C Woodard,et al.  Optimal management of a ventricular assist system. Contribution of flow visualization studies. , 1992, ASAIO journal.

[26]  A. Loh,et al.  Improved technique for polytetrafluoroethylene bypass grafting: Long‐term results using anastomotic vein patches , 1992, The British journal of surgery.

[27]  Kyriacos D. Papailiou,et al.  Computational fluid dynamics '98 , 1998 .