Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells

[1]  K. Hasegawa,et al.  Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human , 2016, Scientific Reports.

[2]  R. Chung,et al.  Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins , 2016, Genome Medicine.

[3]  Charles Y. Chiu,et al.  Erratum to: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing , 2016, Genome Medicine.

[4]  C. Gandhi,et al.  Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in mice , 2015, Hepatology research : the official journal of the Japan Society of Hepatology.

[5]  N. Ferreirós,et al.  Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection , 2015, Hepatology.

[6]  R. Schwabe,et al.  Hepatic inflammation and fibrosis: Functional links and key pathways , 2015, Hepatology.

[7]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[8]  C. Trautwein,et al.  ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. , 2014, Journal of hepatology.

[9]  Jing Yang,et al.  Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy. , 2014, Biological & pharmaceutical bulletin.

[10]  Paul Theodor Pyl,et al.  HTSeq – A Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[11]  J. Kornhuber,et al.  Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. , 2014, Biochimica et biophysica acta.

[12]  R. Schwabe,et al.  Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology , 2013, Nature Communications.

[13]  D. Brenner,et al.  Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts , 2013, Current Pathobiology Reports.

[14]  P. Janmey,et al.  Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[15]  R. Schwabe,et al.  Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. , 2012, Gastroenterology.

[16]  R. Weichselbaum,et al.  Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S] , 2012, Journal of Lipid Research.

[17]  Christopher K. Glass,et al.  Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis , 2012, Proceedings of the National Academy of Sciences.

[18]  Brad T. Sherman,et al.  DAVID-WS: a stateful web service to facilitate gene/protein list analysis , 2012, Bioinform..

[19]  J. Brouwers,et al.  Replacement of Retinyl Esters by Polyunsaturated Triacylglycerol Species in Lipid Droplets of Hepatic Stellate Cells during Activation , 2012, PloS one.

[20]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[21]  Jiaquan Xu,et al.  Deaths: final data for 2009. , 2011, National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System.

[22]  S. Yue,et al.  Essential roles of sphingosine 1‐phosphate receptor types 1 and 3 in human hepatic stellate cells motility and activation , 2011, Journal of cellular physiology.

[23]  J. Ladero.  Noninvasive Evaluation of Liver Fibrosis in Patients with Chronic Hepatitis C , 2011, Hepatitis monthly.

[24]  H. Tsukamoto,et al.  Epigenetic cell fate regulation of hepatic stellate cells , 2011, Hepatology research : the official journal of the Japan Society of Hepatology.

[25]  C. Bedia,et al.  Acid Ceramidase Expression Modulates the Sensitivity of A375 Melanoma Cells to Dacarbazine* , 2011, The Journal of Biological Chemistry.

[26]  Liying Li,et al.  Sphingosine 1-phosphate (S1P)/S1P receptors are involved in human liver fibrosis by action on hepatic myofibroblasts motility. , 2011, Journal of hepatology.

[27]  Y. Hannun,et al.  Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases , 2011, British journal of pharmacology.

[28]  C. Bedia,et al.  A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease , 2010, Journal of Lipid Research.

[29]  R. Bataller,et al.  Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. , 2010, The American journal of pathology.

[30]  Y. Hannun,et al.  Regulated Secretion of Acid Sphingomyelinase , 2010, The Journal of Biological Chemistry.

[31]  Y. Inoue,et al.  Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. , 2010, Clinica chimica acta; international journal of clinical chemistry.

[32]  Cole Trapnell,et al.  Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.

[33]  S. Yue,et al.  Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. , 2009, The American journal of pathology.

[34]  Eigen R. Peralta,et al.  Ceramide starves cells to death by downregulating nutrient transporter proteins , 2008, Proceedings of the National Academy of Sciences.

[35]  D. Im,et al.  Activity Change of Sphingomyelin Anabolic Enzymes during Dimethylnitrosamine-induced Hepatic Fibrosis in Rats , 2008 .

[36]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[37]  J. Kornhuber,et al.  Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. , 2008, Journal of medicinal chemistry.

[38]  D. Peake,et al.  Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization. , 2007, Biochimica et biophysica acta.

[39]  P. Gillman.  Tricyclic antidepressant pharmacology and therapeutic drug interactions updated , 2007, British journal of pharmacology.

[40]  Geoffrey J Barton,et al.  The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. , 2007, Journal of molecular biology.

[41]  Y. Hannun,et al.  Acid Ceramidase but Not Acid Sphingomyelinase Is Required for Tumor Necrosis Factor-α-induced PGE2 Production* , 2006, Journal of Biological Chemistry.

[42]  Y. Hannun,et al.  New insights on the use of desipramine as an inhibitor for acid ceramidase , 2006, FEBS letters.

[43]  A. Bielawska,et al.  Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. , 2006, Methods.

[44]  D. Brenner,et al.  Erratum: Liver fibrosis (Journal of Clinical Investigation (2005) 115 (209-218) DOI:10.1172/JCI200524282) , 2005 .

[45]  H. Tsukamoto,et al.  Adipogenic Transcriptional Regulation of Hepatic Stellate Cells* , 2005, Journal of Biological Chemistry.

[46]  S. Friedman,et al.  Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis , 2004, Gut.

[47]  Y. Hannun,et al.  Sphingolipids in inflammation: roles and implications. , 2004, Current molecular medicine.

[48]  A. Bielawska,et al.  The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts , 2004, The Prostate.

[49]  K. Sandhoff,et al.  Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine , 2004, FEBS letters.

[50]  K. Hanada,et al.  Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. , 2003, Biochimica et biophysica acta.

[51]  J. Iredale,et al.  Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells. , 2003, Matrix biology : journal of the International Society for Matrix Biology.

[52]  N. Sohara,et al.  Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate. , 2002, Journal of hepatology.

[53]  H. Rüdiger,et al.  Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. , 2001, Cancer research.

[54]  W. Potter,et al.  Metabolism of Tricyclic Antidepressants , 1999, Cellular and Molecular Neurobiology.

[55]  S. Spiegel,et al.  Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase* , 1998, The Journal of Biological Chemistry.

[56]  A. Merrill,et al.  Characterization of Ceramide Synthesis , 1997, The Journal of Biological Chemistry.

[57]  J. Iredale,et al.  Pathogenesis of liver fibrosis. , 1997, Clinical science.

[58]  D. Rockey,et al.  Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance , 1996, Hepatology.

[59]  Y. Hirabayashi,et al.  Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[60]  R. Desnick,et al.  Purification, characterization, and biosynthesis of human acid ceramidase , 1995, The Journal of Biological Chemistry.

[61]  K. Sandhoff,et al.  The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. , 1994, Biological chemistry Hoppe-Seyler.

[62]  S. Friedman,et al.  Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture , 1992, Hepatology.

[63]  R. Desnick,et al.  Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. , 1991, The Journal of biological chemistry.

[64]  S. Friedman,et al.  Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[65]  J. Hauw,et al.  Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures. , 1981, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

[66]  E. Kostetsky,et al.  A universal reagent for phospholipid analysis. , 1975, Journal of chromatography.

[67]  K. Wake.  "Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A. , 1971, The American journal of anatomy.

[68]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[69]  P. Sancho-Bru,et al.  Assessment of Liver Fibrotic Insults In Vitro. , 2015, Methods in molecular biology.

[70]  Liying Li,et al.  GASTROINTESTINAL, HEPATOBILIARY, AND PANCREATIC PATHOLOGY Intracellular Sphingosine 1-Phosphate Contributes to Collagen Expression of Hepatic Myofibroblasts in Human Liver Fibrosis Independent of Its Receptors , 2015 .

[71]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[72]  S. Friedman.  Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. , 2008, Physiological reviews.

[73]  M. Horowitz,et al.  Acid beta-glucosidase: enzymology and molecular biology of Gaucher disease. , 1990, Critical reviews in biochemistry and molecular biology.

[74]  M. Horowitz,et al.  Acid β-Glucosidase: Enzymology and Molecular Biology of Gaucher Diseas , 1990 .

[75]  F. Bianchi,et al.  Desmin and actin in the identification of Ito cells and in monitoring their evolution to myofibroblasts in experimental liver fibrosis , 1988, Virchows Archiv. B, Cell pathology including molecular pathology.