Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation.

[1]  W. Denny,et al.  A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors , 2010, Cancer Chemotherapy and Pharmacology.

[2]  G. Song,et al.  Role of hypoxia in the hallmarks of human cancer , 2009, Journal of cellular biochemistry.

[3]  C. Turro,et al.  Live cell cytotoxicity studies: documentation of the interactions of antitumor active dirhodium compounds with nuclear DNA. , 2009, Journal of the American Chemical Society.

[4]  V. Arán,et al.  Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: electrochemical behaviour and ESR spectroscopic studies. , 2009, European journal of medicinal chemistry.

[5]  B. Garat,et al.  Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs. , 2009, Bioorganic & medicinal chemistry.

[6]  H. Yasuda,et al.  Solid tumor physiology and hypoxia-induced chemo/radio-resistance: novel strategy for cancer therapy: nitric oxide donor as a therapeutic enhancer. , 2008, Nitric oxide : biology and chemistry.

[7]  H. Cerecetto,et al.  Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides. , 2008, Chemical research in toxicology.

[8]  M. Cascante,et al.  Antitumoral effect of phenazine N5,N10-dioxide derivatives on Caco-2 cells. , 2008, Chemical research in toxicology.

[9]  F. Avilés,et al.  DNA interaction and antiproliferative behavior of the water soluble platinum supramolecular squares [(en)Pt(N-N)]4(NO3)8 (en=ethylenediamine, N-N=4,4'-bipyridine or 1,4-bis(4-pyridyl)tetrafluorobenzene). , 2007, Journal of inorganic biochemistry.

[10]  J. Silber,et al.  Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives , 2005, Molecules.

[11]  M. Cascante,et al.  Effect of new antioxidant cysteinyl‐flavanol conjugates on skin cancer cells , 2005, FEBS letters.

[12]  S. Yarmoluk,et al.  Cyanine dyes as intercalating agents: kinetic and thermodynamic studies on the DNA/Cyan40 and DNA/CCyan2 systems. , 2005, Biophysical journal.

[13]  A. López de Cerain,et al.  Phenazine 5,10-dioxide derivatives as hypoxic selective cytotoxins. , 2005, Journal of medicinal chemistry.

[14]  W. Denny.  Prodrug strategies in cancer therapy. , 2001, European journal of medicinal chemistry.

[15]  M. Macleod,et al.  A novel approach for analyzing the structure of DNA modified by Benzo[a]pyrene diol epoxide at single-molecule resolution. , 2000, Chemical research in toxicology.

[16]  G. Peluffo,et al.  1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships. , 1999, Journal of medicinal chemistry.

[17]  V. Moreno,et al.  Study of the interaction of DNA with cisplatin and other Pd(II) and Pt(II) complexes by atomic force microscopy. , 1998, Nucleic acids research.

[18]  E. Clarke,et al.  Hypoxia-selective agents derived from quinoxaline 1,4-di-N-oxides. , 1995, Journal of medicinal chemistry.

[19]  S. Rockwell,et al.  Hypoxic fractions of human tumors xenografted into mice: a review. , 1990, International journal of radiation oncology, biology, physics.

[20]  M. Lemmon,et al.  Structure-activity relationships for benzotriazine di-N-oxides. , 1989, International journal of radiation oncology, biology, physics.

[21]  A. Sartorelli,et al.  Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. , 1972, Journal of medicinal chemistry.

[22]  B. Dominy,et al.  New route to phenazine 5,10-dioxides and related compounds , 1972 .