Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium.

[1]  R. Gonsette Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity , 2008, Journal of the Neurological Sciences.

[2]  Weiling Zhao,et al.  NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. , 2008, Free radical biology & medicine.

[3]  D. Busija,et al.  Cerebromicrovascular endothelial cells are resistant to L-glutamate. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[4]  G. Perry,et al.  Alzheimer disease and the role of free radicals in the pathogenesis of the disease. , 2008, CNS & neurological disorders drug targets.

[5]  K. Chung,et al.  Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain , 2007, PAIN.

[6]  R. Flower,et al.  Glutamate-stimulated peroxynitrite production in a brain-derived endothelial cell line is dependent on N-methyl-d-aspartate (NMDA) receptor activation , 2007, Biochemical pharmacology.

[7]  M. Esiri,et al.  Down‐regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease , 2006, Journal of neurochemistry.

[8]  S. Przedborski Pathogenesis of nigral cell death in Parkinson's disease. , 2005, Parkinsonism & related disorders.

[9]  C. D. Sharp,et al.  N-methyl-D-aspartate receptor activation in human cerebral endothelium promotes intracellular oxidant stress. , 2005, American journal of physiology. Heart and circulatory physiology.

[10]  M. Mattson,et al.  Cell death in HIV dementia , 2005, Cell Death and Differentiation.

[11]  N. Abbott Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation , 2005, Cellular and Molecular Neurobiology.

[12]  P. Heusler,et al.  The superoxide anion is involved in the induction of long-term potentiation in the rat somatosensory cortex in vitro , 2004, Brain Research.

[13]  M. Nedergaard,et al.  The blood–brain barrier: an overview Structure, regulation, and clinical implications , 2004, Neurobiology of Disease.

[14]  C. D. Sharp,et al.  Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. , 2003, American journal of physiology. Heart and circulatory physiology.

[15]  J. Pachter,et al.  Culture of murine brain microvascular endothelial cells that maintain expression and cytoskeletal association of tight junction-associated proteins , 2003, In Vitro Cellular & Developmental Biology - Animal.

[16]  A. Mero,et al.  Serum amino acid concentrations in aging men and women , 2003, Amino Acids.

[17]  C. Leffler,et al.  Ionotropic Glutamate Receptors in Cerebral Microvascular Endothelium are Functionally Linked to Heme Oxygenase , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  E. Klann,et al.  Role of reactive oxygen species in hippocampal long‐term potentiation: Contributory or inhibitory? , 2002, Journal of neuroscience research.

[19]  C. Bolton,et al.  Modulation of blood-brain barrier dysfunction and neurological deficits during acute experimental allergic encephalomyelitis by the N-methyl-D-aspartate receptor antagonist memantine. , 2002, The Journal of pharmacology and experimental therapeutics.

[20]  G. Horgan,et al.  Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR , 2002 .

[21]  E. Klann,et al.  Potentiation of Hippocampal Synaptic Transmission by Superoxide Requires the Oxidative Activation of Protein Kinase C , 2002, The Journal of Neuroscience.

[22]  D. Jezova,et al.  N-Acetyl-l-aspartyl-l-glutamate changes functional and structural properties of rat blood–brain barrier , 2002, Neuroscience Letters.

[23]  J. Macdonald,et al.  Convergence of PKC-dependent kinase signal cascades on NMDA receptors. , 2001, Current drug targets.

[24]  Mark Farrant,et al.  NMDA receptor subunits: diversity, development and disease , 2001, Current Opinion in Neurobiology.

[25]  Y. Michotte,et al.  Neurochemical changes and laser Doppler flowmetry in the endothelin-1 rat model for focal cerebral ischemia , 2000, Brain Research.

[26]  R. Kean,et al.  The Peroxynitrite Scavenger Uric Acid Prevents Inflammatory Cell Invasion into the Central Nervous System in Experimental Allergic Encephalomyelitis through Maintenance of Blood-Central Nervous System Barrier Integrity1 , 2000, The Journal of Immunology.

[27]  P. Maher,et al.  Signaling by reactive oxygen species in the nervous system , 2000, Cellular and Molecular Life Sciences CMLS.

[28]  R. Dempsey,et al.  Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. , 2000, Neurosurgery.

[29]  N. Abbott Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability , 2000, Cellular and Molecular Neurobiology.

[30]  H. Koprowski,et al.  Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood–CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  A. Grinberg,et al.  Increased blood–brain barrier permeability in LP-BM5 infected mice is mediated by neuroexcitatory mechanisms , 1999, Brain Research.

[32]  E. Klann,et al.  Modulation of protein kinases and protein phosphatases by reactive oxygen species: Implications for hippocampal synaptic plasticity , 1999, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[33]  S. Love Oxidative Stress in Brain Ischemia , 1999, Brain pathology.

[34]  F. Joó,et al.  Expression of glutamate receptors on cultured cerebral endothelial cells , 1998, Journal of neuroscience research.

[35]  E. Preston,et al.  Lack of evidence for direct involvement of NMDA receptors or polyamines in blood–brain barrier injury after cerebral ischemia in rats , 1998, Brain Research.

[36]  G. Mealing,et al.  Evidence that Functional Glutamate Receptors are not Expressed on Rat or Human Cerebromicrovascular Endothelial Cells , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[37]  J. Sweatt,et al.  A Role for Superoxide in Protein Kinase C Activation and Induction of Long-term Potentiation* , 1998, The Journal of Biological Chemistry.

[38]  C. Bolton,et al.  MK-801 limits neurovascular dysfunction during experimental allergic encephalomyelitis. , 1997, The Journal of pharmacology and experimental therapeutics.

[39]  G. Wilcock,et al.  Current approaches to the treatment of Alzheimer's disease. , 1996, Neurodegeneration.

[40]  S. Lipton,et al.  Excitatory amino acids as a final common pathway for neurologic disorders. , 1994, The New England journal of medicine.

[41]  J. Coyle,et al.  Oxidative stress, glutamate, and neurodegenerative disorders. , 1993, Science.

[42]  F. Fonnum Glutamate: A Neurotransmitter in Mammalian Brain , 1984, Journal of neurochemistry.

[43]  P Riederer,et al.  Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. , 2007, Journal of Alzheimer's disease : JAD.

[44]  Anthony W. Newman Free Radical Biology & Medicine , 2005 .

[45]  M. Küçük,et al.  Reduction of Edema and Infarction by Memantine and MK-801 After Focal Cerebral Ischaemia and Reperfusion in Rat , 2000, Acta Neurochirurgica.

[46]  A. Guidotti Neurotoxicity of excitatory amino acids , 1990 .

[47]  P. Mcgeer,et al.  Kainic acid as a tool in neurobiology , 1978 .