The effect of acute fenitrothion exposure on a variety of physiological indices, including avian aerobic metabolism during exercise and cold exposure

The effect of fenitrothion exposure on birds was examined by measuring aerobic metabolism, blood hemoglobin content, plasma cholinesterases, and body weight for up to 21 d postdose. Peak metabolic rate was measured in a flight chamber in three‐dose groups of house sparrows (Passer domesticus; 100 mg/kg = high, 60 mg/kg = medium, 30 mg/kg = low) and one‐dose groups of zebra finches (Taeniopygia guttata; 3 mg/kg) and king quails (Coturnix chinensis; 26 mg/kg). Aerobic metabolism was measured during 1 h of exposure to subfreezing thermal conditions in low‐dose house sparrows and king quails (26 mg/kg). Fenitrothion had no effect on metabolic rate during cold exposure or on blood hemoglobin at any time. By contrast, aerobic performance during exercise in sparrows was reduced by 58% (high), 18% (medium), and 20% (low), respectively, 2 d postdose. House sparrows (high) had the longest recovery period for peak metabolic rate (21 d) and plasma cholinesterase activity (14 d). House sparrows (high) and treated king quails had significantly lower myoglobin at 48 h postdose, whereas myoglobin was invariant in zebra finches and house sparrows (medium and low). Cholinesterase was maximally inhibited at 6 h postdose, and had recovered within 24 h, in house sparrows (low), king quails, and zebra finches. Exercise peak metabolic rate in zebra finches and king quails was reduced by 23% at 2 d and 3 d, respectively, despite these birds being asymptomatic in both behavior and plasma cholinesterase activities.

[1]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.

[2]  M. Rosenmann,et al.  Maximum oxygen consumption and heat loss facilitation in small homeotherms by He-O2. , 1974, The American journal of physiology.

[3]  W. Rautenberg,et al.  Thermoregulatory effects of intrahypothalamic injections of neurotransmitters and their inhibitors in the pigeon. , 1975, Comparative biochemistry and physiology. A, Comparative physiology.

[4]  C. Grue,et al.  Response of common grackles to dietary concentrations of four organophosphate pesticides , 1982, Archives of environmental contamination and toxicology.

[5]  J. Franson,et al.  Methyl parathion and fenvalerate toxicity in American kestrels: acute physiological responses and effects of cold. , 1984, Canadian journal of physiology and pharmacology.

[6]  J. Franson,et al.  Toxicity of abate® 4E (temephos) in mallard ducklings and the influence of cold , 1985 .

[7]  R. Baudinette,et al.  Thermoregulation, Oxygen-Consumption and Water Turnover in Stubble Quail, Coturnix-Pectoralis, and King Quail, Coturnix-Chinensis , 1986 .

[8]  T. E. Martin.  Food as a limit on breeding birds: a life-history perspective , 1987 .

[9]  B. Rattner,et al.  Enhancement of parathion toxicity to quail by heat and cold exposure , 1987 .

[10]  R. Marsh,et al.  Avian Adjustments to Cold , 1989 .

[11]  P. Boag,et al.  Effects of the organophosphorus pesticide fenitrothion on behavior and reproduction in zebra finches. , 1990, Environmental research.

[12]  M. E. Murphy,et al.  Estimates of the mass of structures other than plumage produced during molt by white-crowned sparrows , 1990 .

[13]  R. Macmillen,et al.  Maximum metabolism and the aerobic factorial scope of endotherms. , 1993, The Journal of experimental biology.

[14]  M. Hooper,et al.  AGE-DEPENDENT CHANGES IN PLASMA AND BRAIN CHOLINESTERASE ACTIVITIES OF EASTERN BLUEBIRDS AND EUROPEAN STARLINGS , 1993, Journal of wildlife diseases.

[15]  R. Dufva.  Blood parasites, health, reproductive success, and egg volume in female Great Tits Parus major , 1996 .

[16]  C. Grue,et al.  Neurophysiological and Behavioral Changes in Non-Target Wildlife Exposed to Organophosphate and Carbamate Pesticides: Thermoregulation, Food Consumption, and Reproduction , 1997 .

[17]  M. Zuk,et al.  Aerobic performance does not affect social rank in female Red Jungle Fowl , 1999 .

[18]  W. Buttemer,et al.  The relationship of central and peripheral organ masses to aerobic performance variation in house sparrows , 1999, The Journal of experimental biology.

[19]  A. Lill,et al.  Variation during breeding in parameters that influence blood oxygen carrying capacity in shearwaters , 2000 .

[20]  C. Vianna,et al.  Thermogenesis in Birds , 2001, Bioscience reports.

[21]  F. Punzo.  Effects of Carbaryl-Treated Bait on Maternal Behavior and Sprint Performance in the Meadow Jumping Mouse, Zapus hudsonius , 2003, Bulletin of environmental contamination and toxicology.

[22]  M. Hooper,et al.  Effects of sublethal fenitrothion ingestion on cholinesterase inhibition, standard metabolism, thermal preference, and prey‐capture ability in the Australian central bearded dragon (Pogona vitticeps, agamidae) , 2004, Environmental toxicology and chemistry.

[23]  C. T. Winne,et al.  Differential swimming performance of two natricine snakes exposed to a cholinesterase-inhibiting pesticide. , 2005, Environmental pollution.

[24]  J. Bicudo,et al.  Control and Regulatory Mechanisms Associated with Thermogenesis in Flying Insects and Birds , 2005, Bioscience reports.

[25]  M. Hooper,et al.  Cholinesterase response in native birds exposed to fenitrothion during locust control operations in eastern Australia , 2006, Environmental toxicology and chemistry.

[26]  M. Whiteside,et al.  Lethal risk to birds from insecticide use in the United States—a spatial and temporal analysis , 2006, Environmental toxicology and chemistry.

[27]  W. A. Hopkins,et al.  Effect of Acute Exposure to Malathion and Lead on Sprint Performance of the Western Fence Lizard (Sceloporus occidentalis) , 2006, Archives of environmental contamination and toxicology.

[28]  S. DuRant,et al.  Impaired terrestrial and arboreal locomotor performance in the western fence lizard (Sceloporus occidentalis) after exposure to an AChE-inhibiting pesticide. , 2007, Environmental pollution.

[29]  W. Buttemer,et al.  Testosterone effects on avian basal metabolic rate and aerobic performance: facts and artefacts. , 2008, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[30]  R. Baudinette,et al.  Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata). , 2008, Chemosphere.