Dorsal root projections to dorsal horn neurons in the cat spinal cord

The projection of dorsal root fibers to the dorsal horn of the spinal cord of the cat has been studied by electron microscopy. Two distinct types of synaptic degeneration are seen with the electron microscope: small knobs which exhibit a marked increase in electron density, and large knobs which fill with neurofilaments. Variations in the distribution of degenerating knobs to the six laminae of the dorsal horn are observed: dense degenerating knobs are found throughout the horn, but are quite rare in laminae I and II. Lamina III exhibits the most dense knobs, and a great many are also present in laminae IV and VI with a somewhat lesser number seen in lamina V. Knobs undergoing neurofilamentous degeneration are found only in laminae V and VI, and are much Jess frequently seen than are dense knobs.

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