Development and validation of a multiclass method for the quantification of veterinary drug residues in honey and royal jelly by liquid chromatography-tandem mass spectrometry.

The aim of this study was to develop an analytical method for the analysis of a wide range of veterinary drugs in honey and royal jelly. A modified sample preparation procedure based on the quick, easy, cheap, effective, rugged and safe (QuEChERS) method was developed, followed by liquid chromatography tandem mass spectrometry determination. Use of the single sample preparation method for analysis of 42 veterinary drugs becomes more valuable because honey and royal jelly belong to completely different complex matrices. Another main advantage of the proposed method is its ability to identify and quantify 42 veterinary drugs with higher sensitivity than reference methods of China. This work has shown that the reported method was demonstrated to be convenient and reliable for the quick monitoring of veterinary drugs in honey and royal jelly samples.

[1]  M. Montague,et al.  Laboratory and field studies on the effects of the antibiotic tylosin on honey bee Apis mellifera L. (Hymenoptera: Apidae) development and prevention of American foulbrood disease. , 1996, Journal of invertebrate pathology.

[2]  Shao-rong Lei,et al.  A multi-residue method for the determination of pesticides in tea using multi-walled carbon nanotubes as a dispersive solid phase extraction absorbent. , 2014, Food chemistry.

[3]  Ying Liu,et al.  Modified QuEChERS method combined with ultra-high performance liquid chromatography tandem mass spectrometry for the simultaneous determination of 26 mycotoxins in sesame butter. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[4]  R. Sheridan,et al.  Analysis and occurrence of 14 sulfonamide antibacterials and chloramphenicol in honey by solid-phase extraction followed by LC/MS/MS analysis. , 2008, Journal of agricultural and food chemistry.

[5]  A. Klein,et al.  Importance of pollinators in changing landscapes for world crops , 2007, Proceedings of the Royal Society B: Biological Sciences.

[6]  B. Foley,et al.  Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS) , 2010, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[7]  J. Zhao,et al.  Simultaneous determination of seven fluoroquinolones in royal jelly by ultrasonic-assisted extraction and liquid chromatography with fluorescence detection. , 2009, Journal of separation science.

[8]  Marek Biziuk,et al.  Determination of pesticide residues in food matrices using the QuEChERS methodology , 2011 .

[9]  Jianying Hu,et al.  Simultaneous analysis of 16 sulfonamide and trimethoprim antibiotics in environmental waters by liquid chromatography-electrospray tandem mass spectrometry. , 2008, Journal of chromatography. A.

[10]  K. Delaplane.  Honey bees and beekeeping , 2010 .

[11]  Jing Zhao,et al.  Floral classification of honey using liquid chromatography-diode array detection-tandem mass spectrometry and chemometric analysis. , 2014, Food chemistry.

[12]  T. Echigo,et al.  Chemical composition of royal jelly. , 1980 .

[13]  Yolanda Picó,et al.  Progress in analysis of residual antibacterials in food , 2007 .

[14]  Jian Wang.  Determination of five macrolide antibiotic residues in honey by LC-ESI-MS and LC-ESI-MS/MS. , 2004, Journal of agricultural and food chemistry.

[15]  Emmanuelle Vulliet,et al.  Determination of 136 pharmaceuticals and hormones in sewage sludge using quick, easy, cheap, effective, rugged and safe extraction followed by analysis with liquid chromatography-time-of-flight-mass spectrometry. , 2013, Journal of chromatography. A.

[16]  S. Bogdanov.  Contaminants of bee products , 2006 .

[17]  R. Sram,et al.  Genotoxicity and carcinogenicity of metronidazole. , 1994, Mutation research.

[18]  T. Hankemeier,et al.  Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery , 2012, Analytical and Bioanalytical Chemistry.

[19]  H. D. De brabander,et al.  Validation of the tetrasensor honey test kit for the screening of tetracyclines in honey. , 2007, Journal of agricultural and food chemistry.

[20]  Yiyang Dong,et al.  Development of an indirect competitive assay-based aptasensor for highly sensitive detection of tetracycline residue in honey. , 2014, Biosensors & bioelectronics.

[21]  Suxia Zhang,et al.  Simultaneous determination of nitroimidazole residues in honey samples by high-performance liquid chromatography with ultraviolet detection. , 2007, Journal of AOAC International.

[22]  M. M. Rahman,et al.  Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria. , 2010, The Journal of antimicrobial chemotherapy.

[23]  A. G. Frenich,et al.  Multiclass analysis of antibiotic residues in honey by ultraperformance liquid chromatography-tandem mass spectrometry. , 2009, Journal of agricultural and food chemistry.

[24]  Yahong Liu,et al.  Development of a modified QUick, Easy, CHeap, Effective, Rugged and Safe method for the determination of multi-class antimicrobials in vegetables by liquid chromatography tandem mass spectrometry. , 2014, Journal of chromatography. A.

[25]  J. Pettis,et al.  Multiclass determination and confirmation of antibiotic residues in honey using LC-MS/MS. , 2008, Journal of agricultural and food chemistry.

[26]  F. Lestremau,et al.  A really quick easy cheap effective rugged and safe (QuEChERS) extraction procedure for the analysis of particle-bound PAHs in ambient air and emission samples. , 2013, The Science of the total environment.

[27]  Jian Wang,et al.  The challenges of developing a generic extraction procedure to analyze multi-class veterinary drug residues in milk and honey using ultra-high pressure liquid chromatography quadrupole time-of-flight mass spectrometry. , 2012, Drug testing and analysis.

[28]  E. Dubreil-Chéneau,et al.  Confirmation of 13 sulfonamides in honey by liquid chromatography-tandem mass spectrometry for monitoring plans: validation according to European Union Decision 2002/657/EC. , 2014, Journal of chromatography. A.

[29]  Jian Wang,et al.  Analyses of macrolide antibiotic residues in eggs, raw milk, and honey using both ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and high-performance liquid chromatography/tandem mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.

[30]  R. Bottini,et al.  High-throughput method based on quick, easy, cheap, effective, rugged and safe followed by liquid chromatography-multi-wavelength detection for the quantification of multiclass polyphenols in wines. , 2014, Journal of chromatography. A.

[31]  Steven J Lehotay,et al.  Fast and easy multiresidue method employing acetonitrile extraction/partitioning and "dispersive solid-phase extraction" for the determination of pesticide residues in produce. , 2003, Journal of AOAC International.

[32]  W. Siangproh,et al.  A flow injection method for the analysis of tetracycline antibiotics in pharmaceutical formulations using electrochemical detection at anodized boron-doped diamond thin film electrode. , 2004, Talanta.

[33]  L. Malone,et al.  Effects of time, temperature, and honey on Nosema apis (Microsporidia: Nosematidae), a parasite of the honeybee, Apis mellifera (Hymenoptera: Apidae). , 2001, Journal of invertebrate pathology.