Effect of long-term treatment with sodium valproate on gonadotrophin and prolactin secretion in paediatric patients.

1 Luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin levels were measured in twenty paediatric patients receiving sodium valproate (30 mg/kg body weight daily) and in ten control subjects under control conditions and following LRH-TRH administration. In addition, baseline GH levels were measured in the two groups. 2 No significant differences were observed between the basal and stimulated hormone levels in the two groups. Although sodium valproate may act as anticonvulsant by increasing GABA levels in the central nervous system, the present data indicate that a central GABAergic pathway is probably not involved in the control of gonadotrophin and prolactin secretion.

[1]  T. Meloni,et al.  Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in children receiving phenobarbitone. , 1980, British medical journal.

[2]  C. Invitti,et al.  Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. , 1980, Acta endocrinologica.

[3]  J. Takahara,et al.  Concomitant Increases in Serum Growth Hormone and Hypothalamic Somatostatin in Rats after Injection of γ-Aminobutyric Acid, Aminooxyacetic Acid, or γ-Hydroxybutyric Acid , 1980 .

[4]  P. Batalden,et al.  Pancreatitis associated with valproic acid therapy. , 1979, Pediatrics.

[5]  A. Guidotti,et al.  gamma-Aminobutyric acid receptor function in rat anterior pituitary: evidence for control of prolactin release. , 1979, Endocrinology.

[6]  M. Koulu,et al.  Stimulatory effect of acute baclofen administration on human growth hormone secretion. , 1979, The Journal of clinical endocrinology and metabolism.

[7]  C. Invitti,et al.  Effect of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man , 1979 .

[8]  M. Koulu,et al.  The effect of methysergide, pimozide, and sodium valproate on the diazepam-stimulated growth hormone secretion in man. , 1979, The Journal of clinical endocrinology and metabolism.

[9]  B. Wilder,et al.  Effect of valproic acid on hepatic function , 1978, Neurology.

[10]  G. Knöpfle,et al.  Effects of Anticonvulsant Drugs on Thyroid Hormones in Epileptic Children , 1978, Epilepsia.

[11]  N. Andén,et al.  Biochemical effects of baclofen (beta-parachlorophenyl-GABA) on the dopamine and the noradrenaline in the rat brain. , 2009, Acta pharmacologica et toxicologica.

[12]  C. Invitti,et al.  Effects of a gamma aminobutyric acid (GABA) derivative, baclofen, on growth hormone and prolactin secretion in man. , 1977, The Journal of clinical endocrinology and metabolism.

[13]  J. Ondo,et al.  The effects of gamma-aminobutyric acid on prolactin and gonadotropin secretion in the unanesthetized rat. , 1977, Endocrinology.

[14]  J. Takahara,et al.  Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans. , 1977, The Journal of clinical endocrinology and metabolism.

[15]  A. Schally,et al.  Isolation of gamma-amino butyric acid from pig hypothalami and demonstration of its prolactin release-inhibiting (PIF) activity in vivo and in vitro. , 1977, Endocrinology.

[16]  J. Ondo.  Gamma-aminobutyric acid effects on pituitary gonadotropin secretion. , 1975, Science.

[17]  H. Bein,et al.  Sites of Action of a New Muscle Relaxant (Baclofen, Lioresal®, Ciba 34 647–Ba) , 1974 .

[18]  E. Stark,et al.  Effects of gamma-aminobutyric acid (GABA) and GABA antagonist drugs on ACTH release. , 1974, Neuroendocrinology.

[19]  P. Mandel,et al.  EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM 1 , 1969, Journal of neurochemistry.