Fixed‐effect versus random‐effect models for evaluating therapeutic preferences

A preference trial is a special form of cross‐over trial where clinical conditions determine when patients change treatment, in a prescribed order. This leads to binary responses with variable lengths. In cross‐over trials with normal responses, patient effect may be treated as either fixed or random. However, with binary responses, random‐ and fixed‐effect assumptions may lead to very different conclusions, so that one is no longer an alternative to the other. Copyright © 2002 John Wiley & Sons, Ltd.

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