Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork
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[1] P. Hieter,et al. An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development , 2013, PLoS genetics.
[2] Steven J. M. Jones,et al. Comprehensive genomic characterization of squamous cell lung cancers , 2012, Nature.
[3] Grant W. Brown,et al. Dissecting DNA damage response pathways by analyzing protein localization and abundance changes during DNA replication stress , 2012, Nature Cell Biology.
[4] Arul M Chinnaiyan,et al. PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma. , 2012, Cancer research.
[5] S. Ramaswamy,et al. Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.
[6] Adam A. Margolin,et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.
[7] P. Hieter,et al. Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators , 2012, PLoS genetics.
[8] David Pellman,et al. Causes and consequences of aneuploidy in cancer , 2012, Nature Reviews Genetics.
[9] P. Hieter,et al. R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. , 2012, Genes & development.
[10] F. Spencer,et al. Mutability and mutational spectrum of chromosome transmission fidelity genes , 2011, Chromosoma.
[11] L. Loeb,et al. Human cancers express mutator phenotypes: origin, consequences and targeting , 2011, Nature Reviews Cancer.
[12] S. Moreno,et al. Lsm1 promotes genomic stability by controlling histone mRNA decay , 2011, The EMBO journal.
[13] Zoltan Szallasi,et al. Paradoxical relationship between chromosomal instability and survival outcome in cancer. , 2011, Cancer research.
[14] Frederick S. Vizeacoumar,et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants , 2011, Nature Biotechnology.
[15] Zhijian Li,et al. The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components , 2011, PLoS genetics.
[16] S. Gruber,et al. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. , 2011, Cancer research.
[17] Alan Ashworth,et al. Searching for synthetic lethality in cancer. , 2011, Current opinion in genetics & development.
[18] C. Ponting,et al. Identification of the MMS22L-TONSL complex that promotes homologous recombination. , 2010, Molecular cell.
[19] Grant W. Brown,et al. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. , 2010, Molecular cell.
[20] C. Obuse,et al. Cul8/Rtt101 Forms a Variety of Protein Complexes That Regulate DNA Damage Response and Transcriptional Silencing* , 2010, The Journal of Biological Chemistry.
[21] M. O’Connor,et al. ATM Deficiency Sensitizes Mantle Cell Lymphoma Cells to Poly(ADP-Ribose) Polymerase-1 Inhibitors , 2010, Molecular Cancer Therapeutics.
[22] M. Kupiec,et al. Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of Mms22, a Protein Important for DNA Repair , 2010, PLoS genetics.
[23] Gary D Bader,et al. The Genetic Landscape of a Cell , 2010, Science.
[24] Gary D. Bader,et al. DRYGIN: a database of quantitative genetic interaction networks in yeast , 2009, Nucleic Acids Res..
[25] C. Myers,et al. Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe. , 2010, Methods in enzymology.
[26] P. Hieter,et al. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. , 2009, Molecular biology of the cell.
[27] D. Drubin,et al. A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms. , 2009, Developmental cell.
[28] Richard C. Jones,et al. A key role for Ctf4 in coupling the MCM2‐7 helicase to DNA polymerase α within the eukaryotic replisome , 2009, The EMBO journal.
[29] G. Giaever,et al. Quantitative Phenotyping via Deep Barcode Sequencing , 2022 .
[30] J. Hurwitz,et al. Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins , 2009, Proceedings of the National Academy of Sciences.
[31] Michael J. Emanuele,et al. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.
[32] Sridhar Ramaswamy,et al. Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells , 2009, Cell.
[33] M. Stratton,et al. The cancer genome , 2009, Nature.
[34] P. Hieter,et al. Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing , 2009, Proceedings of the National Academy of Sciences.
[35] Michel Roberge,et al. Screening for chemical inhibitors of heterologous proteins expressed in yeast using a simple growth-restoration assay. , 2009, Methods in molecular biology.
[36] Sean R. Collins,et al. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome , 2008, Nature Methods.
[37] Kathryn A. O’Donnell,et al. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. , 2008, Molecular cell.
[38] Robert P. St.Onge,et al. The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes , 2008, Science.
[39] G. Parmigiani,et al. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers , 2008, Proceedings of the National Academy of Sciences.
[40] Jean Gautier,et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. , 2008, Nature chemical biology.
[41] Eun Mi Kim,et al. DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore , 2008, PLoS genetics.
[42] Anindya Dutta,et al. Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication , 2007 .
[43] Grant W. Brown,et al. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map , 2007, Nature.
[44] F. Spencer,et al. Systematic genome instability screens in yeast and their potential relevance to cancer , 2007, Proceedings of the National Academy of Sciences.
[45] Anindya Dutta,et al. Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. , 2007, Genes & development.
[46] B. Weaver,et al. Does aneuploidy cause cancer? , 2006, Current opinion in cell biology.
[47] Inmar E. Givoni,et al. Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast , 2006, Cell.
[48] W. Kaelin. The Concept of Synthetic Lethality in the Context of Anticancer Therapy , 2005, Nature Reviews Cancer.
[49] Thomas Helleday,et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase , 2005, Nature.
[50] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[51] J. Ptak,et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. , 2004, Cancer research.
[52] V. Zakian,et al. Saccharomyces cerevisiae Rrm3p DNA Helicase Promotes Genome Integrity by Preventing Replication Fork Stalling: Viability of rrm3 Cells Requires the Intra-S-Phase Checkpoint and Fork Restart Activities , 2004, Molecular and Cellular Biology.
[53] Carlo Rago,et al. Inactivation of hCDC4 can cause chromosomal instability , 2004, Nature.
[54] T. Hubbard,et al. A census of human cancer genes , 2004, Nature Reviews Cancer.
[55] Gary D Bader,et al. Global Mapping of the Yeast Genetic Interaction Network , 2004, Science.
[56] Michael I. Jordan,et al. Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[57] P. Shannon,et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.
[58] Ronald W. Davis,et al. Functional profiling of the Saccharomyces cerevisiae genome , 2002, Nature.
[59] Tyson A. Clark,et al. Removal of a Single α-Tubulin Gene Intron Suppresses Cell Cycle Arrest Phenotypes of Splicing Factor Mutations in Saccharomyces cerevisiae , 2002, Molecular and Cellular Biology.
[60] Gary D Bader,et al. Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants , 2001, Science.
[61] A. Murray,et al. Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. , 2001, Genetics.
[62] L. Hartwell,et al. Integrating genetic approaches into the discovery of anticancer drugs. , 1997, Science.
[63] K. Nasmyth,et al. Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids , 1997, Cell.
[64] F. Spencer,et al. Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. , 1990, Genetics.