Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

[1]  R. Medema,et al.  Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras , 1994, Molecular and cellular biology.

[2]  M. Nakafuku,et al.  Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors. , 1994, The Journal of biological chemistry.

[3]  T. Okada,et al.  Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. , 1994, The Journal of biological chemistry.

[4]  E. Ravussin,et al.  Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. , 1993, The New England journal of medicine.

[5]  T. Yagi,et al.  A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice , 1993, Nature.

[6]  M. White,et al.  Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Baker,et al.  Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) , 1993, Cell.

[8]  M. White,et al.  IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. , 1993, Science.

[9]  Y. Yazaki,et al.  Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. , 1993, The Journal of biological chemistry.

[10]  T. Kadowaki,et al.  Normal insulin receptor substrate-1 phosphorylation in autophosphorylation-defective truncated insulin receptor. Evidence that phosphorylation of substrates might be sufficient for certain biological effects evoked by insulin. , 1993, The Journal of biological chemistry.

[11]  Nanxin Li,et al.  The function of GRB2 in linking the insulin receptor to Ras signaling pathways. , 1993, Science.

[12]  T. Pawson,et al.  The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. , 1993, The Journal of biological chemistry.

[13]  K. Ueki,et al.  Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. , 1993, The Journal of biological chemistry.

[14]  G. Lienhard,et al.  Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[15]  G. Lienhard,et al.  The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. , 1993, The Journal of biological chemistry.

[16]  M. DePamphilis,et al.  Origins of DNA replication in metazoan chromosomes. , 1993, The Journal of biological chemistry.

[17]  M. Kasuga,et al.  Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. , 1992, The Journal of biological chemistry.

[18]  B. Margolis,et al.  Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. , 1992, The EMBO journal.

[19]  R. Mooney,et al.  Insulin stimulates the tyrosine phosphorylation of a 61-kilodalton protein in rat adipocytes. , 1992, Endocrinology.

[20]  E. Nishida,et al.  Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. , 1991, The Journal of biological chemistry.

[21]  C. Kahn,et al.  Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein , 1991, Nature.

[22]  C. Kahn,et al.  Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. , 1991, The Journal of biological chemistry.

[23]  G. Reaven,et al.  Regulation of insulin receptor functions by a peptide derived from a major histocompatibility complex class I antigen , 1990, Cell.

[24]  L. Chasin,et al.  Nonsense mutations in the dihydrofolate reductase gene affect RNA processing , 1989, Molecular and cellular biology.

[25]  M. Kasuga,et al.  Insulin-induced tyrosine-phosphorylation in intact rat adipocytes. , 1988, Biochemical and biophysical research communications.

[26]  A. Ullrich,et al.  Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity , 1988, Cell.

[27]  M. Kasuga,et al.  Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell. , 1987, The Journal of biological chemistry.

[28]  C. Kahn,et al.  Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells , 1985, Nature.