EMT: when epithelial cells decide to become mesenchymal-like cells.

Epithelial-mesenchymal transition (EMT) is critical for appropriate embryonic development, and this process is re-engaged in adults during wound healing, tissue regeneration, organ fibrosis, and cancer progression. Inflammation is a crucial conspirator in the emergence of EMT in adults but is absent during embryonic development. As highlighted in this Review series, EMT is now a recognized mechanism for dispersing cells in embryos, forming fibroblasts/mesenchymal cells in injured tissues, and initiating metastasis of epithelial cancer cells. Also discussed are proposals to classify EMT into three subtypes, each of which has different functional consequences.

[1]  M. Nieto,et al.  Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. , 2009, The Journal of clinical investigation.

[2]  J. Thiery.  Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.

[3]  R. McKay,et al.  Plasticity, niches, and the use of stem cells. , 2002, Developmental cell.

[4]  M. Rastaldi,et al.  Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies. , 2002, Kidney international.

[5]  Anne Vincent-Salomon,et al.  Epithelial–mesenchymal transition in breast cancer development , 2003 .

[6]  R. Knuechel,et al.  Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[7]  B. Boyer,et al.  Induction and regulation of epithelial-mesenchymal transitions. , 2000, Biochemical pharmacology.

[8]  E. Neilson,et al.  Biomarkers for epithelial-mesenchymal transitions. , 2009, The Journal of clinical investigation.

[9]  J. Downward,et al.  Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis , 2002, The Journal of Cell Biology.

[10]  R. Kalluri,et al.  Epithelial-mesenchymal transition and its implications for fibrosis. , 2003, The Journal of clinical investigation.

[11]  Raghu Kalluri,et al.  Fibroblasts in cancer , 2006, Nature Reviews Cancer.

[12]  M. Nieto,et al.  The snail superfamily of zinc-finger transcription factors , 2002, Nature Reviews Molecular Cell Biology.

[13]  E. Neilson,et al.  The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. , 2003, Cancer research.

[14]  P. Ekblom.  Genetics of kidney development. , 1996, Current opinion in nephrology and hypertension.

[15]  C. Rohrmeier,et al.  Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease , 2008, Inflammatory bowel diseases.

[16]  Marc D. H. Hansen,et al.  Cell polarity: Versatile scaffolds keep things in place , 1999, Current Biology.

[17]  Charis Eng,et al.  Direct evidence for epithelial-mesenchymal transitions in breast cancer. , 2008, Cancer research.

[18]  Raghu Kalluri,et al.  The basics of epithelial-mesenchymal transition. , 2009, The Journal of clinical investigation.

[19]  R. Figlin,et al.  Tumor Response to Combination Celecoxib and Erlotinib Therapy in Non-small Cell Lung Cancer Is Associated with a Low Baseline Matrix Metalloproteinase-9 and a Decline in Serum-Soluble E-Cadherin , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[20]  A. Kiemer,et al.  Identification of genes involved in epithelial-mesenchymal transition and tumor progression , 2001, Oncogene.