Arterial elastic modulus reconstruction from in-vivo strain image using arterial pressure equalization

A non-invasive free-hand ultrasound scanning procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. An elastic modulus reconstruction procedure was developed to estimate the nonlinear elastic properties of the vascular wall from intramural strain measurements. The undistended elastic modulus of the diseased group is about an order of magnitude larger than that of the normal group. In-vivo measurements demonstrate the feasibility of the clinical application of this technique.

[1]  J. Cohn,et al.  Relationship between periventricular or deep white matter lesions and arterial elasticity indices in very old people. , 2001, Age and ageing.

[2]  A. Bank,et al.  In vivo human brachial artery elastic mechanics: effects of smooth muscle relaxation. , 1999, Circulation.

[3]  T. Loupas,et al.  Arterial pulse wave velocity with tissue Doppler imaging. , 2002, Ultrasound in medicine & biology.

[4]  K. Leunissen,et al.  Arterial compliance in patients on long-treatment-time dialysis. , 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[5]  O. Bonnefous,et al.  New TDI developments for vascular and cardiac applications , 2000, 2000 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.00CH37121).

[6]  J. Blacher,et al.  Impact of aortic stiffness on survival in end-stage renal disease. , 1999, Circulation.

[7]  G. Langewouters,et al.  The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model. , 1984, Journal of biomechanics.

[8]  T. Shoji,et al.  Femoral artery wall thickness and stiffness in evaluation of peripheral vascular disease in type 2 diabetes mellitus. , 2001, Atherosclerosis.

[9]  J M Rubin,et al.  Vascular intramural strain imaging using arterial pressure equalization. , 2004, Ultrasound in medicine & biology.

[10]  O. Bonnefous,et al.  Non invasive echographic techniques for arterial wall characterization , 1996, 1996 IEEE Ultrasonics Symposium. Proceedings.

[11]  M.A. Lubinski,et al.  Speckle tracking methods for ultrasonic elasticity imaging using short-time correlation , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[12]  Michael F Insana,et al.  Strain imaging of internal deformation. , 2002, Ultrasound in medicine & biology.