Shapes of membrane permeability-lipophilicity curves: extension of theoretical models with an aqueous pore pathway.

[1]  G Folkers,et al.  Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. , 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[2]  John R. King,et al.  Percutaneous absorption: a multiple pathway model , 1997 .

[3]  R. Borchardt,et al.  How structural features influence the biomembrane permeability of peptides. , 1996, Journal of pharmaceutical sciences.

[4]  O. H. Chan,et al.  Physicochemical and drug-delivery considerations for oral drug bioavailability , 1996 .

[5]  G Folkers,et al.  Review of theoretical passive drug absorption models: historical background, recent developments and limitations. , 1996, Pharmaceutica acta Helvetiae.

[6]  L. Benet,et al.  Active secretion and enterocytic drug metabolism barriers to drug absorption 1 PII of original artic , 1996 .

[7]  Han van de Waterbeemd,et al.  Lipophilicity in Drug Action and Toxicology: Pliška/Lipophilicity , 1996 .

[8]  C. Pidgeon,et al.  Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability. , 1996, Journal of chromatography. A.

[9]  H. Girault,et al.  Mechanism of transfer of a basic drug across the water 1,2-dichloroethane interface: The case of quinidine , 1996 .

[10]  G. Camenisch Drug transport across membranes , 1996 .

[11]  Han van de Waterbeemd,et al.  Estimation of Caco‐2 Cell Permeability using Calculated Molecular Descriptors , 1996 .

[12]  Han van de Waterbeemd,et al.  Lipophilicity in drug action and toxicology , 1996 .

[13]  Thomas J. Raub,et al.  Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers. , 1995, Journal of pharmaceutical sciences.

[14]  R. Conradi,et al.  A biophysical model of passive and polarized active transport processes in Caco-2 cells: approaches to uncoupling apical and basolateral membrane events in the intact cell. , 1995, Journal of pharmaceutical sciences.

[15]  Thomas J. Raub,et al.  Quantitative approaches to delineate paracellular diffusion in cultured epithelial cell monolayers. , 1994, Journal of pharmaceutical sciences.

[16]  Thomas J. Raub,et al.  Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers. , 1993, Journal of drug targeting.

[17]  N. Vermeulen,et al.  Comprehensive medicinal chemistry , 1991 .

[18]  M. Bermejo,et al.  Gastric absorption of acidic xenobiotics in the rat : biophysical interpretation of an apparently atypical behaviour , 1990 .

[19]  W. Nimmo,et al.  Novel drug delivery and its therapeutic application , 1989 .

[20]  J. K. Seydel,et al.  QSAR and strategies in the design of bioactive compounds , 1985 .

[21]  W. Higuchi,et al.  Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and humans , 1983 .

[22]  E. Kutter,et al.  11 - Absorption, Distribution, and Metabolism of Drugs , 1983 .

[23]  W. Crouthamel,et al.  Animal models for oral drug delivery in man : in situ and in vivo approaches , 1983 .

[24]  J. Topliss Quantitative structure-activity relationships of drugs , 1983 .

[25]  H Kubinyi,et al.  Lipophilicity and drug activity. , 1979, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

[26]  Edward B. Roche,et al.  Design of biopharmaceutical properties through prodrugs and analogs , 1977 .

[27]  H. Kubinyi Quantitative structure-activity relationships. IV. Non-linear dependence of biological activity on hydrophobic character: a new model. , 1976, Arzneimittel-Forschung.

[28]  D B Black,et al.  Diffusion layer effects on permeation of phenylbutazone through polydimethylsiloxane. , 1974, Journal of pharmaceutical sciences.

[29]  S. Yalkowsky,et al.  Effects of alkyl chain length on biological activity: alkyl p-aminobenzoate-induced narcosis in goldfish. , 1974, Journal of pharmaceutical sciences.

[30]  S. Yalkowsky,et al.  Mass transport phenomena and models: theoretical concepts. , 1974, Journal of pharmaceutical sciences.

[31]  W. R. Lieb,et al.  The Molecular Basis of Simple Diffusion within Biological Membranes , 1972 .

[32]  W. Higuchi,et al.  In vitro model for transport of solutes in three-phase system. I. Theoretical principles. , 1972, Journal of pharmaceutical sciences.

[33]  A. Leo,et al.  Partition coefficients and their uses , 1971 .

[34]  W. Higuchi,et al.  Quantitative interpretation of in vivo buccal absorption of n-alkanoic acids by the physical model approach. , 1971, Journal of pharmaceutical sciences.

[35]  C. Hansch Quantitative approach to biochemical structure-activity relationships , 1969 .

[36]  T. Arita,et al.  Absorption and excretion of drugs. XXX. Absorption of barbituric acid derivatives from rat stomach. , 1967, Chemical & pharmaceutical bulletin.

[37]  R. Scheuplein Analysis of permeability data for the case of parallel diffusion pathways. , 1966, Biophysical journal.

[38]  B. Brodie,et al.  The gastric secretion of drugs: a pH partition hypothesis. , 1957, The Journal of pharmacology and experimental therapeutics.

[39]  R. Collander,et al.  The Partition of Organic Compounds Between Higher Alcohols and Water. , 1951 .

[40]  R. Collander,et al.  The Distribution of Organic Compounds Between iso-Butanol and Water. , 1950 .