Generation of diversity in thymic epithelial cells
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Graham Anderson | Y. Takahama | G. Anderson | Yousuke Takahama | Izumi Ohigashi | Song Baik | I. Ohigashi | Song Baik
[1] G. Anderson,et al. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium , 2006, Nature.
[2] Kathy E. O’Neill,et al. Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus , 2016, Cell reports.
[3] L. Peltonen,et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains , 1997, Nature Genetics.
[4] B. Kyewski,et al. Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells , 2007, European journal of immunology.
[5] Natalie A. Roberts,et al. Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium , 2012, Immunity.
[6] T. Abe,et al. Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma , 2011, The Journal of Immunology.
[7] M. Fallahi,et al. Spatial mapping of thymic stromal microenvironments reveals unique features influencing T lymphoid differentiation. , 2009, Immunity.
[8] Y. Nakagawa,et al. Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes , 2012, Proceedings of the National Academy of Sciences.
[9] C. Ponting,et al. Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla , 2016, European journal of immunology.
[10] E. Stanley,et al. Rewiring immunity: generating a functional thymus from hESCs… are we there yet? , 2013, Cell stem cell.
[11] The Celluar Basis of the Immune Response , 1982 .
[12] Shinsei Minoshima,et al. Positional cloning of the APECED gene , 1997, Nature Genetics.
[13] J. Coligan,et al. Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development , 1994, The Journal of experimental medicine.
[14] A. Silverstein. History of immunology. , 1996 .
[15] R. Kingston,et al. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3 , 2010, Proceedings of the National Academy of Sciences.
[16] K. Mita,et al. Loss of SDF-1 receptor expression during positive selection in the thymus. , 1998, International immunology.
[17] K. Rohr,et al. Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity , 2013, Proceedings of the National Academy of Sciences.
[18] N. L. La Gruta,et al. Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection , 2016, The Journal of experimental medicine.
[19] T. Boehm,et al. Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage , 2010, Proceedings of the National Academy of Sciences.
[20] Y. Hayashi,et al. CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. , 2006, Immunity.
[21] J. D. Di Santo,et al. Thymocyte Selection Regulates the Homeostasis of IL-7–Expressing Thymic Cortical Epithelial Cells In Vivo , 2013, The Journal of Immunology.
[22] J. Penninger,et al. RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla , 2007, The Journal of Experimental Medicine.
[23] J. D. Di Santo,et al. Cutting Edge: A Thymocyte-Thymic Epithelial Cell Cross-Talk Dynamically Regulates Intrathymic IL-7 Expression In Vivo , 2010, The Journal of Immunology.
[24] S. Yagi,et al. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator , 2016, The Journal of experimental medicine.
[25] F. Jotereau,et al. Tracing of cells of the avian thymus through embryonic life in interspecific chimeras , 1975, The Journal of experimental medicine.
[26] D. Roopenian,et al. Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence , 2011, PLoS genetics.
[27] H. Ploegh,et al. Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83 , 2016, The Journal of experimental medicine.
[28] Keiji Tanaka,et al. Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t , 2011, European journal of immunology.
[29] Y. Takahama,et al. Development and function of cortical thymic epithelial cells. , 2014, Current topics in microbiology and immunology.
[30] H. Petrie,et al. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. , 2007, Annual review of immunology.
[31] D. Gray,et al. Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus. , 2014, Cell reports.
[32] Y. Takahama,et al. Development and developmental potential of cortical thymic epithelial cells , 2016, Immunological reviews.
[33] R. de Waal Malefyt,et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development , 2011, The Journal of experimental medicine.
[34] Y. Takahama,et al. Lymphotoxin β Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells , 2013, The Journal of Immunology.
[35] B. Kyewski,et al. Adult Thymus Contains FoxN1− Epithelial Stem Cells that Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages , 2014, Immunity.
[36] A. Carrier,et al. Thymus‐specific serine protease regulates positive selection of a subset of CD4+ thymocytes , 2009, European journal of immunology.
[37] N. Bredenkamp,et al. Regeneration of the aged thymus by a single transcription factor , 2014, Development.
[38] T. Hara,et al. Identification of IL-7–Producing Cells in Primary and Secondary Lymphoid Organs Using IL-7–GFP Knock-In Mice , 2012, The Journal of Immunology.
[39] C. Ware,et al. The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells1 , 2008, The Journal of Immunology.
[40] Zicheng Hu,et al. CCR4 promotes medullary entry and thymocyte–dendritic cell interactions required for central tolerance , 2015, The Journal of experimental medicine.
[41] Scott N. Mueller,et al. Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. , 2011, Blood.
[42] L. Klein,et al. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see) , 2014, Nature Reviews Immunology.
[43] T. Boehm,et al. Regenerative capacity of adult cortical thymic epithelial cells , 2012, Proceedings of the National Academy of Sciences.
[44] N. Manley,et al. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment , 2008 .
[45] J. Timmer,et al. A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β , 2016, Cell reports.
[46] L. Klein,et al. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self , 2001, Nature Immunology.
[47] H. Takayanagi,et al. The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. , 2008, Immunity.
[48] Y. Takahama,et al. Journey through the thymus: stromal guides for T-cell development and selection , 2006, Nature Reviews Immunology.
[49] D. Roop,et al. Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[50] I. Gimenez-Conti,et al. Cutting Edge: Thymocyte-Independent and Thymocyte-Dependent Phases of Epithelial Patterning in the Fetal Thymus1 , 2002, The Journal of Immunology.
[51] Mark S. Anderson,et al. Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein , 2002, Science.
[52] D. Gray,et al. CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes , 2004, The Journal of experimental medicine.
[53] S. Tonegawa,et al. Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development. , 1990, Journal of immunology.
[54] S. Parnell,et al. Checkpoints in the Development of Thymic Cortical Epithelial Cells1 , 2009, The Journal of Immunology.
[55] Jürgen Schulte Mönting,et al. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell , 2006, Nature.
[56] B. Kyewski,et al. Lymphoepithelial interactions in the mouse thymus: phenotypic and kinetic studies on thymic nurse cells. , 1982, Journal of immunology.
[57] G. Conteduca. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance , 2009 .
[58] H. Takayanagi,et al. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. , 2008, Immunity.
[59] Keiji Tanaka,et al. Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells , 2013, Proceedings of the National Academy of Sciences.
[60] G. Anderson,et al. Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors , 2016, European journal of immunology.
[61] A. Cumano,et al. Characterization of the thymic IL-7 niche in vivo , 2009, Proceedings of the National Academy of Sciences.
[62] C. Benoist,et al. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity , 2009, The Journal of experimental medicine.
[63] Mark S. Anderson,et al. AIRE expands: new roles in immune tolerance and beyond , 2016, Nature Reviews Immunology.
[64] E. Levanon,et al. Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells , 2016, Genome Biology.
[65] N. Manley,et al. Developing a new paradigm for thymus organogenesis , 2004, Nature Reviews Immunology.
[66] B. Becher,et al. Alternative NF‐κB signaling regulates mTEC differentiation from podoplanin‐expressing precursors in the cortico‐medullary junction , 2015, European journal of immunology.
[67] C. Ponting,et al. Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells , 2016, Nature Immunology.
[68] T. Boehm,et al. Laser capture microdissection‐based expression profiling identifies PD1‐ligand as a target of the nude locus gene product , 2001, European journal of immunology.
[69] David Zemmour,et al. Aire controls gene expression in the thymic epithelium with ordered stochasticity , 2015, Nature Immunology.
[70] D. Gray,et al. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. , 2006, Blood.
[71] Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes , 2013 .
[72] G. Anderson,et al. CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells , 2016, Cell reports.
[73] J. Dudakov,et al. Thymus: the next (re)generation , 2016, Immunological reviews.
[74] G. Anderson,et al. Generation of both cortical and Aire+ medullary thymic epithelial compartments from CD205+ progenitors , 2013, European journal of immunology.
[75] B. Kyewski,et al. Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism , 2008, Proceedings of the National Academy of Sciences.
[76] J. Heremans,et al. Nude Mouse Embryo: Ectodermal Nature of the Primordial Thymic Defect , 1975, Scandinavian journal of immunology.
[77] Natalie A. Roberts,et al. Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult , 2009, European journal of immunology.
[78] H. Wekerle,et al. Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation? , 1980, Nature.
[79] Qi-hua He,et al. Differentiation of Human Embryonic Stem Cells into Thymic Epithelial Progenitor-like Cells Reconstitutes the Thymic Microenvironment In Vivo , 2013 .
[80] Jingjun Jin,et al. Generation of Thymic Epithelial Cell Progenitors by Mouse Embryonic Stem Cells , 2009, Stem cells.
[81] Y. Takahama,et al. Serial progression of cortical and medullary thymic epithelial microenvironments , 2013, European journal of immunology.
[82] G. Morahan,et al. The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[83] Kathy E. O’Neill,et al. An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts , 2014, Nature Cell Biology.
[84] N. Minato,et al. Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance. , 2014, Immunity.
[85] Yinhong Song,et al. Efficient in vitro generation of functional thymic epithelial progenitors from human embryonic stem cells , 2015, Scientific Reports.
[86] H. Rodewald,et al. Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus , 2015, The Journal of Immunology.
[87] J. Caamaño,et al. Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells , 2010, The Journal of Immunology.
[88] N. Manley,et al. Functional evidence for a single endodermal origin for the thymic epithelium , 2004, Nature Immunology.
[89] P. Rodrigues,et al. Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymus , 2014, European journal of immunology.
[90] Wolfgang Huber,et al. Single-cell transcriptome analysis reveals coordinated ectopic gene expression patterns in medullary thymic epithelial cells , 2015, Nature Immunology.
[91] S. Parnell,et al. Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development , 2015, The Journal of Immunology.
[92] L. Peltonen,et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels , 2005, The Journal of experimental medicine.
[93] A. Sergé,et al. Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive αβT Cells in the Adult Thymus , 2014, The Journal of Immunology.
[94] H. Bluethmann,et al. Thymus medulla consisting of epithelial islets each derived from a single progenitor , 2001, Nature.
[95] B. Kyewski,et al. Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapy. , 2007, Cancer research.
[96] S. Scheu,et al. Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR , 2003, The Journal of experimental medicine.
[97] M. Duvic. New member of the winged-helix protein family disrupted in mouse and rat nude mutations , 1995 .
[98] J. Gordon,et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. , 2014, Immunity.
[99] G. Holländer,et al. Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes , 1995, Nature.
[100] B. Kyewski,et al. The thymic medulla: a unique microenvironment for intercellular self-antigen transfer , 2009, The Journal of experimental medicine.
[101] L. Davis,et al. Cutting Edge: Thymic Crosstalk Regulates Delta-Like 4 Expression on Cortical Epithelial Cells1 , 2008, The Journal of Immunology.
[102] K. Willecke,et al. Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells , 2010, Proceedings of the National Academy of Sciences.
[103] A. Rudensky,et al. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. , 1998, Science.
[104] C. Benoist,et al. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated , 2008, Proceedings of the National Academy of Sciences.
[105] A. Cordier,et al. Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice. , 1980, The American journal of anatomy.
[106] S. Parnell,et al. Control of the thymic medulla and its influence on αβT‐cell development , 2016, Immunological reviews.
[107] P. Peterson,et al. Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens , 2012, Front. Immun..
[108] E. Stanley,et al. FOXN1GFP/w Reporter hESCs Enable Identification of Integrin-β4, HLA-DR, and EpCAM as Markers of Human PSC-Derived FOXN1+ Thymic Epithelial Progenitors , 2014, Stem cell reports.
[109] T. Kodama,et al. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance , 2015, Cell.
[110] C. Benoist,et al. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire , 2007, The Journal of experimental medicine.
[111] Satoru Takahashi,et al. Temporal Lineage Tracing of Aire-Expressing Cells Reveals a Requirement for Aire in Their Maturation Program , 2014, The Journal of Immunology.
[112] Y. Takahama,et al. Thymic epithelial cells: working class heroes for T cell development and repertoire selection. , 2012, Trends in immunology.
[113] N. Minato,et al. Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors. , 2015, Cell reports.
[114] Reidar Andreson,et al. AIRE activated tissue specific genes have histone modifications associated with inactive chromatin , 2009, Human molecular genetics.
[115] C. Blackburn,et al. FOXN1 in thymus organogenesis and development , 2016, European journal of immunology.
[116] H. Rodewald. Thymus organogenesis. , 2008, Annual review of immunology.
[117] C. Ponting,et al. Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia , 2014, Genome research.
[118] G. Anderson,et al. An Epithelial Progenitor Pool Regulates Thymus Growth1 , 2008, The Journal of Immunology.
[119] Mark S. Anderson,et al. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. , 2013, Cell stem cell.
[120] A. Denman,et al. The Cellular Basis of the Immune Response , 1982 .
[121] Mark S. Anderson,et al. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. , 2013, Cell reports.