Heart Rate Recovery and Cancer Risk: Prospective Cohort Study

This study aims to determine the association between 2-minute heart rate recovery (HRR) and cancer risk. Each participant (5379 women; 8485 men) provided HRR obtained from treadmill tests. The outcome was site-specific cancer. Over 9 years of follow-up, 630 cancer events (258 women) were accrued. Slower HRR was associated with increased thyroid cancer risk in women (P for trend = .0121) and colorectal cancer risk in men (P for trend = .0034). The lowest HRR (<13 bpm) had higher hazards of thyroid cancer (hazard ratio [HR] = 2.20; 95% CI = 1.28-3.77) in women and colorectal cancer (HR = 3.08; 95% CI = 1.32-7.15) in men. In women, slower HRR and lower proportions of heart rate recovery (PHRR) were associated with higher hazards of thyroid cancer in women and metabolically related cancers (liver and colorectal) in men. Slower HRR and lower PHRR were independent risk factors for thyroid cancer in women and metabolically related cancers in men.

[1]  I. Janszky,et al.  Resting heart rate and the risk of cardiovascular disease, total cancer, and all-cause mortality - A systematic review and dose-response meta-analysis of prospective studies. , 2017, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[2]  Gyu Jang Lee,et al.  Physical Activity Level and Colorectal Cancer Mortality , 2016, Asia-Pacific journal of public health.

[3]  Yoon-Ho Choi,et al.  Exercise Heart Rate Reserve and Recovery as Predictors of Incident Type 2 Diabetes. , 2016, The American journal of medicine.

[4]  S. Jee,et al.  Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans , 2016, Epidemiology and health.

[5]  R. Rauramaa,et al.  Cardiorespiratory fitness, C-reactive protein and lung cancer risk: A prospective population-based cohort study. , 2015, European journal of cancer.

[6]  Thomas G. Allison,et al.  Cardiopulmonary Fitness and Heart Rate Recovery as Predictors of Mortality in a Referral Population , 2014, Journal of the American Heart Association.

[7]  M. Leitzmann,et al.  Physical activity, diabetes, and risk of thyroid cancer: a systematic review and meta-analysis , 2013, European Journal of Epidemiology.

[8]  S. Jee,et al.  Physical Activity Level and Risk of Death: The Severance Cohort Study , 2012, Journal of epidemiology.

[9]  E. Platz,et al.  Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies , 2012, Cancer Causes & Control.

[10]  D. Laaksonen,et al.  Two‐minute heart rate recovery after cycle ergometer exercise and all‐cause mortality in middle‐aged men , 2011, Journal of internal medicine.

[11]  Sun-Mi Lee,et al.  Risk Factors and a Predictive Model for Thyroid Cancer in Korean Women , 2010, Cancer nursing.

[12]  S. Grundy,et al.  Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International As , 2009, Circulation.

[13]  Yasuo Ohashi,et al.  Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. , 2009, JAMA.

[14]  S. Andò,et al.  17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30 , 2006, Molecular Pharmacology.

[15]  D. Jacobs,et al.  A longitudinal study of physical activity and heart rate recovery: CARDIA, 1987-1993. , 2005, Medicine and science in sports and exercise.

[16]  Chung S. Yang,et al.  Mechanisms of cancer prevention by tea constituents. , 2003, The Journal of nutrition.

[17]  M. Lauer,et al.  Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. , 2003, Diabetes care.

[18]  C. Friedenreich,et al.  Physical activity and cancer prevention: etiologic evidence and biological mechanisms. , 2002, The Journal of nutrition.

[19]  R. Zeballos,et al.  Clinical exercise testing. , 2001, Clinics in chest medicine.

[20]  G. Schuler,et al.  Physical Activity , 2005, International Journal of Obesity.

[21]  V. Froelicher,et al.  A survey of exercise testing: methods, utilization, interpretation, and safety in the VAHCS. , 2000, Journal of cardiopulmonary rehabilitation.

[22]  E. Howley,et al.  Criteria for maximal oxygen uptake: review and commentary. , 1995, Medicine and science in sports and exercise.

[23]  W. Kannel,et al.  Some health benefits of physical activity. The Framingham Study. , 1979, Archives of internal medicine.

[24]  D. Hosmer,et al.  Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. , 1973, American heart journal.

[25]  S. Blair,et al.  Cardiorespiratory fitness determined by exercise heart rate as a predictor of mortality in the Aerobics Center Longitudinal Study. , 1998, Journal of sports sciences.

[26]  M. Karvonen,et al.  The effects of training on heart rate; a longitudinal study. , 1957, Annales medicinae experimentalis et biologiae Fenniae.

[27]  IARC Handbooks of Cancer Prevention Vitamin , 2022 .