Analysis of excitability for the FitzHugh-Nagumo model via a stochastic sensitivity function technique.

We study excitability phenomena for the stochastically forced FitzHugh-Nagumo system modeling a neural activity. Noise-induced changes in the dynamics of this model can be explained by the high stochastic sensitivity of its attractors. Computational methods based on the stochastic sensitivity functions technique are suggested for the analysis of these attractors. Our method allows us to construct confidence ellipses and estimate a threshold value of a noise intensity corresponding to the neuron excitement. On the basis of the proposed technique, a supersensitive limit cycle is found for the FitzHugh-Nagumo model.

[1]  J. García-Ojalvo,et al.  Effects of noise in excitable systems , 2004 .

[2]  J. Doyne Farmer,et al.  Deterministic noise amplifiers , 1992 .

[3]  L. Ryashko,et al.  NOISE-INDUCED BACKWARD BIFURCATIONS OF STOCHASTIC 3D-CYCLES , 2010 .

[4]  G. Mil’shtein,et al.  A first approximation of the quasipotential in problems of the stability of systems with random non-degenerate perturbations , 1995 .

[5]  Klaus Schulten,et al.  NOISE INDUCED LIMIT CYCLES OF THE BONHOEFFER-VAN DER POL MODEL OF NEURAL PULSES. , 1985 .

[6]  R. FitzHugh Impulses and Physiological States in Theoretical Models of Nerve Membrane. , 1961, Biophysical journal.

[7]  Irina A. Bashkirtseva,et al.  Stochastic sensitivity of 3D-cycles , 2004, Math. Comput. Simul..

[8]  Irina A. Bashkirtseva,et al.  Confidence tori in the analysis of stochastic 3D-cycles , 2009, Math. Comput. Simul..

[9]  Ichiro Tsuda,et al.  Noise-induced order , 1983 .

[10]  Klaus Schulten,et al.  Effect of noise and perturbations on limit cycle systems , 1991 .

[11]  K. Schulten,et al.  Noise-induced neural impulses , 1986, European Biophysics Journal.

[12]  J. Kurths,et al.  Coherence Resonance in a Noise-Driven Excitable System , 1997 .

[13]  Gabriel J. Lord,et al.  Stochastic Methods in Neuroscience , 2009 .

[14]  Jianbo Gao,et al.  When Can Noise Induce Chaos , 1999 .

[15]  L Schimansky-Geier,et al.  Analytical approach to the stochastic FitzHugh-Nagumo system and coherence resonance. , 1999, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[16]  L. Ryashko,et al.  Constructive analysis of noise-induced transitions for coexisting periodic attractors of the Lorenz model. , 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

[17]  Eric Vanden-Eijnden,et al.  Two distinct mechanisms of coherence in randomly perturbed dynamical systems. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[18]  F. Gassmann,et al.  Noise-induced chaos-order transitions , 1997 .

[19]  Irina Bashkirtseva,et al.  Sensitivity analysis of the stochastically and periodically forced Brusselator , 2000 .

[20]  J. M. Sancho,et al.  Coherence and anticoherence resonance tuned by noise. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[21]  L. Schimansky-Geier,et al.  Noise induced complexity: from subthreshold oscillations to spiking in coupled excitable systems. , 2005, Chaos.

[22]  F. Baras,et al.  Stochastic analysis of limit cycle behavior , 1997 .

[23]  V I Nekorkin,et al.  Spiking behavior in a noise-driven system combining oscillatory and excitatory properties. , 2001, Physical review letters.

[24]  A. Longtin Stochastic resonance in neuron models , 1993 .