Leptin action in pubertal development: recent advances and unanswered questions

[1]  R. Frisch.  Fatness, Menarche, and Female Fertility , 2015, Perspectives in biology and medicine.

[2]  J. Elmquist,et al.  The Acute Effects of Leptin Require PI3K Signaling in the Hypothalamic Ventral Premammillary Nucleus , 2011, The Journal of Neuroscience.

[3]  U. Boehm,et al.  Female reproductive maturation in the absence of kisspeptin/GPR54 signaling , 2011, Nature Neuroscience.

[4]  A. Read,et al.  Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene. , 2011, European journal of endocrinology.

[5]  L. Coolen,et al.  Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. , 2011, Endocrinology.

[6]  J. Roa,et al.  Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. , 2011, Endocrinology.

[7]  O. Rønnekleiv,et al.  Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. , 2011, Endocrinology.

[8]  A. Bookout,et al.  Characterization of Kiss1 neurons using transgenic mouse models , 2011, Neuroscience.

[9]  J. Friedman,et al.  Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. , 2011, The Journal of clinical investigation.

[10]  S. Radovick,et al.  Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons , 2010, Proceedings of the National Academy of Sciences.

[11]  C. Elias,et al.  Hypothalamic Sites of Leptin Action Linking Metabolism and Reproduction , 2010, Neuroendocrinology.

[12]  E. Walvoord.  The timing of puberty: is it changing? Does it matter? , 2010, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[13]  C. Elias,et al.  Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons. , 2010, Endocrinology.

[14]  M. Tena-Sempere,et al.  Energy balance and puberty onset: emerging role of central mTOR signaling , 2010, Trends in Endocrinology & Metabolism.

[15]  P. Succop,et al.  Pubertal Assessment Method and Baseline Characteristics in a Mixed Longitudinal Study of Girls , 2010, Pediatrics.

[16]  Christopher R McCartney,et al.  Obesity and the pubertal transition in girls and boys. , 2010, Reproduction.

[17]  E. Littlejohn,et al.  LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity , 2010, International journal of pediatric endocrinology.

[18]  A. Sharif,et al.  Function-related structural plasticity of the GnRH system A role for neuronal–glial–endothelial interactions , 2010, Frontiers in Neuroendocrinology.

[19]  M. Tena-Sempere.  Kisspeptin signaling in the brain: Recent developments and future challenges , 2010, Molecular and Cellular Endocrinology.

[20]  C. Elias,et al.  Male and female odors induce Fos expression in chemically defined neuronal population , 2010, Physiology & Behavior.

[21]  F. Gaytán,et al.  The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. , 2009, Endocrinology.

[22]  P. Leung,et al.  Leptin interferes with 3',5'-Cyclic Adenosine Monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells , 2009, Reproductive biology and endocrinology : RB&E.

[23]  R. Steiner,et al.  Kisspeptin signaling in the brain. , 2009, Endocrine reviews.

[24]  J. Polkowska,et al.  Effect of intracerebroventricular infusion of leptin on the secretory activity of the GnRH/LH axis in fasted prepubertal lambs. , 2009, Animal reproduction science.

[25]  D. Dunger,et al.  Childhood obesity and the timing of puberty , 2009, Trends in Endocrinology & Metabolism.

[26]  C. Kemp,et al.  Leptin indirectly regulates gonadotropin-releasing hormone neuronal function. , 2009, Endocrinology.

[27]  D. Dunger,et al.  Infancy weight gain predicts childhood body fat and age at menarche in girls. , 2009, The Journal of clinical endocrinology and metabolism.

[28]  W. Colledge.  Kisspeptins and GnRH neuronal signalling , 2009, Trends in Endocrinology & Metabolism.

[29]  H. Münzberg,et al.  Direct Innervation of GnRH Neurons by Metabolic- and Sexual Odorant-Sensing Leptin Receptor Neurons in the Hypothalamic Ventral Premammillary Nucleus , 2009, The Journal of Neuroscience.

[30]  R. Lipton,et al.  Thelarche, Pubarche, and Menarche Attainment in Children With Normal and Elevated Body Mass Index , 2009, Pediatrics.

[31]  J. Baik,et al.  Kinesin superfamily-associated protein 3 is preferentially expressed in glutamatergic neurons and contributes to the excitatory control of female puberty. , 2008, Endocrinology.

[32]  J. D. Hahn,et al.  Fasting Reduces KiSS‐1 Expression in the Anteroventral Periventricular Nucleus (AVPV): Effects of Fasting on the Expression of KiSS‐1 and Neuropeptide Y in the AVPV or Arcuate Nucleus of Female Rats , 2008, Journal of neuroendocrinology.

[33]  Jianxin Xie,et al.  The Creb1 coactivator Crtc1 is required for energy balance and fertility , 2008, Nature Medicine.

[34]  R. Lustig,et al.  Adolescent Obesity and Puberty: The “Perfect Storm” , 2008, Annals of the New York Academy of Sciences.

[35]  R. Steiner,et al.  The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction. , 2008, Annual review of physiology.

[36]  S. Swan,et al.  Examination of US Puberty-Timing Data from 1940 to 1994 for Secular Trends: Panel Findings , 2008, Pediatrics.

[37]  P. Lønning,et al.  Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels , 2007, The Journal of Steroid Biochemistry and Molecular Biology.

[38]  P. Kaplowitz.  Pubertal development in girls: secular trends , 2006, Current opinion in obstetrics & gynecology.

[39]  C. Peterson,et al.  Obesity and male reproductive potential. , 2006, Journal of andrology.

[40]  Jun-Fen Fu,et al.  Early activation of the inhibin B/FSH axis in obese Tanner stage G1PH1 boys , 2006, Clinical endocrinology.

[41]  A. Herbison,et al.  Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty , 2006, Molecular and Cellular Endocrinology.

[42]  D. Dunger,et al.  Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size): The European trend , 2006, Molecular and Cellular Endocrinology.

[43]  King-Jen Chang,et al.  Leptin interferes with adrenocorticotropin/3',5'-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-phosphatidylinositol 3-kinase/Akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI- , 2006, The Journal of clinical endocrinology and metabolism.

[44]  J. T. Smith,et al.  KiSS‐1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse , 2006, Journal of neuroendocrinology.

[45]  S. Ojeda,et al.  Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach? , 2006, Endocrinology.

[46]  R. Steiner,et al.  Behavioral / Systems / Cognitive Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty , 2005 .

[47]  Thomas Ludwig,et al.  Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. , 2005, The Journal of clinical investigation.

[48]  D. Dunger,et al.  Effects of obesity on growth and puberty. , 2005, Best practice & research. Clinical endocrinology & metabolism.

[49]  F. Casanueva,et al.  Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. , 2005, Endocrinology.

[50]  C. Elias,et al.  Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats , 2004, Neuroscience.

[51]  C. Sisk,et al.  The neural basis of puberty and adolescence , 2004, Nature Neuroscience.

[52]  L. Coolen,et al.  The Premammillary Hypothalamic Area of the Ewe: Anatomical Characterization of a Melatonin Target Area Mediating Seasonal Reproduction1 , 2004, Biology of reproduction.

[53]  S. O’Rahilly,et al.  The GPR54 gene as a regulator of puberty. , 2004, The New England journal of medicine.

[54]  J. E. Schneider.  Energy balance and reproduction , 2004, Physiology & Behavior.

[55]  T. Horvath,et al.  Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[56]  E. Simpson,et al.  Aromatase: Biologic Relevance of Tissue-Specific Expression , 2004, Seminars in reproductive medicine.

[57]  D. Apter.  The Role of Leptin in Female Adolescence , 2003, Annals of the New York Academy of Sciences.

[58]  E. Génin,et al.  Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Alexander S. Banks,et al.  STAT3 signalling is required for leptin regulation of energy balance but not reproduction , 2003, Nature.

[60]  M. Shahab,et al.  Neuroendocrine mechanisms that delay and initiate puberty in higher primates , 2002, Physiology & Behavior.

[61]  Youfa Wang.  Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. , 2002, Pediatrics.

[62]  Graham M Lord,et al.  Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. , 2002, The Journal of clinical investigation.

[63]  A. Sahu,et al.  A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding , 2002, Nature Neuroscience.

[64]  I. Farooqi,et al.  Leptin and the Onset of Puberty: Insights from Rodent and Human Genetics , 2002, Seminars in reproductive medicine.

[65]  V. Castracane,et al.  When did leptin become a reproductive hormone? , 2002, Seminars in reproductive medicine.

[66]  J. Friedman,et al.  Selective deletion of leptin receptor in neurons leads to obesity. , 2001, The Journal of clinical investigation.

[67]  I. Huhtaniemi,et al.  Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression. , 2001, The Journal of endocrinology.

[68]  E. Terasawa,et al.  Neurobiological mechanisms of the onset of puberty in primates. , 2001, Endocrine reviews.

[69]  J. Bourguignon,et al.  Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y , 2000, Regulatory Peptides.

[70]  D. Foster,et al.  Appearance of a Nocturnal Peak of Leptin Secretion in the Pubertal Rat , 2000, Hormones and Behavior.

[71]  J Licinio,et al.  Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defe , 1999, The Journal of clinical endocrinology and metabolism.

[72]  J. Kitawaki,et al.  Leptin directly stimulates aromatase activity in human luteinized granulosa cells. , 1999, Molecular human reproduction.

[73]  D. Foster,et al.  Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty. , 1999, Biology of reproduction.

[74]  K. Clément,et al.  A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction , 1998, Nature.

[75]  S. Mccann,et al.  Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland. , 1997, Endocrinology.

[76]  G. Koch,et al.  Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. , 1997, Pediatrics.

[77]  K. Mounzih,et al.  Leptin treatment rescues the sterility of genetically obese ob/ob males. , 1997, Endocrinology.

[78]  Hongping,et al.  Leptin is a metabolic signal to the reproductive system. , 1996, Endocrinology.

[79]  R. Frisch.  The right weight: body fat, menarche, and fertility. , 1996, Nutrition.

[80]  D. Brann,et al.  Excitatory Amino Acids: Function and Significance in Reproduction and Neuroendocrine Regulation , 1994, Frontiers in Neuroendocrinology.

[81]  L W Swanson,et al.  Projections of the ventral premammillary nucleus , 1992, The Journal of comparative neurology.

[82]  L. Swanson,et al.  Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study , 1990, The Journal of comparative neurology.

[83]  R. Frisch,et al.  Evidence for a secular trend in age of menarche. , 1982, The New England journal of medicine.

[84]  M. Wilkinson,et al.  Investigation into the hypogonadism of the obese mouse (genotype ob/ob). , 1982, Journal of reproduction and fertility.

[85]  R. Sidman,et al.  A reproductive endocrine profile in the diabetes (db) mutant mouse. , 1979, Biology of reproduction.

[86]  D. Coleman.  Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice , 1978, Diabetologia.

[87]  R. Revelle,et al.  Height and Weight at Menarche and a Hypothesis of Critical Body Weights and Adolescent Events , 1970, Science.

[88]  G. C. Kennedy,et al.  Body weight and food intake as initiating factors for puberty in the rat , 1963, The Journal of physiology.

[89]  M. Korbonits,et al.  Leptin and Puberty: A Review , 2004, Pituitary.

[90]  M. G. Myers.  Leptin receptor signaling and the regulation of mammalian physiology. , 2004, Recent progress in hormone research.

[91]  T. Plant,et al.  Neurobiological mechanisms of puberty in higher primates. , 2004, Human reproduction update.

[92]  J. Bourguignon,et al.  Printed in U.S.A. Copyright © 2000 by The Endocrine Society In Vitro Stimulation of the Prepubertal Rat Gonadotropin-Releasing Hormone Pulse Generator , 2022 .

[93]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.