Definition of phenotype.

[1]  J. Shields,et al.  Genetic Theorizing and Schizophrenia , 1973, British Journal of Psychiatry.

[2]  E. Alf,et al.  The use of extreme groups in assessing relationships , 1975 .

[3]  David B. Allison,et al.  The Rev.: An IBM BASIC program for Bayesian test interpretation , 1992 .

[4]  T. Beaty,et al.  Mendelian inheritance of familial prostate cancer. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[5]  G. Goodwin,et al.  Polymorphism in serotonin transporter gene associated with susceptibility to major depression , 1996, The Lancet.

[6]  Cristina Barlassina,et al.  Polymorphisms of α-adducin and salt sensitivity in patients with essential hypertension , 1997, The Lancet.

[7]  L Zagato,et al.  Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. , 1997, Lancet.

[8]  H. Grönberg,et al.  Segregation analysis of prostate cancer in Sweden: support for dominant inheritance. , 1997, American journal of epidemiology.

[9]  N. Craddock,et al.  Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT) , 1997, Molecular Psychiatry.

[10]  D. Schaid,et al.  Evidence for autosomal dominant inheritance of prostate cancer. , 1998, American journal of human genetics.

[11]  D. Easton,et al.  Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. , 1998, American journal of medical genetics.

[12]  B. Gutiérrez,et al.  Variability in the serotonin transporter gene and increased risk for major depression with melancholia , 1998, Human Genetics.

[13]  D. Ellsworth,et al.  The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping. , 1999, Annals of epidemiology.

[14]  M. Province,et al.  Association between the α-adducin gene and hypertension in the HyperGEN Study , 2000 .

[15]  J. Connell,et al.  &agr;-Adducin and Angiotensin I–Converting Enzyme Polymorphisms in Essential Hypertension , 2000, Hypertension.

[16]  E. Boerwinkle,et al.  Lack of association of 3 functional gene variants with hypertension in African Americans. , 2000, Hypertension.

[17]  C. Bogardus,et al.  A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. , 2000, The Journal of clinical investigation.

[18]  Tom H. Lindner,et al.  Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus , 2000, Nature Genetics.

[19]  E. Boerwinkle,et al.  Association and linkage analysis of the α-adducin gene and blood pressure , 2000 .

[20]  Pak C. Sham,et al.  Analysis of multifactorial disease , 2000 .

[21]  L. Groop,et al.  Role of the Gly460Trp polymorphism of the α-adducin gene in primary hypertension in Scandinavians , 2000, Journal of Human Hypertension.

[22]  N. Liyou,et al.  The 460Trp polymorphism of the human α-adducin gene is not associated with isolated systolic hypertension in elderly Australian Caucasians , 2000, Journal of Human Hypertension.

[23]  T G Schulze,et al.  Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. , 2000, American journal of medical genetics.

[24]  R. Olshen,et al.  Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations. , 2000, American journal of hypertension.

[25]  M. Fornage,et al.  Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. , 2000, American journal of hypertension.

[26]  E. Boerwinkle,et al.  Association and linkage analysis of the alpha-adducin gene and blood pressure. , 2000, American journal of hypertension.

[27]  J. Rice,et al.  Definition of the phenotype. , 2001, Advances in genetics.

[28]  P. Talmud,et al.  Genetic polymorphisms, lipoproteins and coronary artery disease risk , 2001, Current opinion in lipidology.

[29]  alpha-Adducin gene and essential hypertension in China. , 2001, Clinical and experimental hypertension.

[30]  J. Staessen,et al.  Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population , 2001, Journal of hypertension.

[31]  Li Jin,et al.  α-ADDUCIN GENE AND ESSENTIAL HYPERTENSION IN CHINA , 2001 .

[32]  M. Province,et al.  Genetic dissection of complex traits , 2001 .

[33]  K. Lesch,et al.  Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders. , 2001, American journal of medical genetics.

[34]  R. Drozd,et al.  Lack of Association between Gly460Trp Polymorphism of Alpha-Adducin Gene and Salt Sensitivity of Blood Pressure in Polish Hypertensives , 2001, Kidney and Blood Pressure Research.

[35]  H. Tsai,et al.  Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association. , 2001, American journal of human genetics.

[36]  B. Zinman,et al.  Absence of association of type 2 diabetes with CAPN10 and PC-1 polymorphisms in Oji-Cree. , 2001, Diabetes care.

[37]  M. McCarthy,et al.  Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. , 2001, American journal of human genetics.

[38]  D. Moczulski,et al.  Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population. , 2002, European journal of endocrinology.

[39]  Kaisa Silander,et al.  Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort. , 2002, Diabetes.

[40]  C. Hanis,et al.  Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians. , 2002, The Journal of clinical endocrinology and metabolism.

[41]  Alex P. Reiner,et al.  Diuretic Therapy, the α-Adducin Gene Variant, and the Risk of Myocardial Infarction or Stroke in Persons With Treated Hypertension , 2002 .

[42]  C. Lindgren,et al.  Variants in the calpain-10 gene predispose to insulin resistance and elevated free fatty acid levels. , 2002, Diabetes.

[43]  Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms. , 2002, The Journal of clinical endocrinology and metabolism.

[44]  J. Staessen,et al.  Association between hypertension and variation in the alpha- and beta-adducin genes in a white population. , 2002, Kidney international.

[45]  Weiping Jia,et al.  [The UCSNP44 variation of calpain 10 gene on NIDDM1 locus and its impact on plasma glucose levels in type 2 diabetic patients]. , 2002, Zhonghua yi xue za zhi.

[46]  Wei Huang,et al.  Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China. , 2002, Biomedical and environmental sciences : BES.

[47]  J. Staessen,et al.  Association between hypertension and variation in the α- and β-adducin genes in a white population , 2002 .

[48]  T. Hansen,et al.  Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. , 2002, Diabetes.

[49]  Yutaka Imai,et al.  Alpha-adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study , 2002, Journal of hypertension.

[50]  J. Ott,et al.  Power and Sample Size Calculations for Case-Control Genetic Association Tests when Errors Are Present: Application to Single Nucleotide Polymorphisms , 2002, Human Heredity.

[51]  Alan E. Jackson,et al.  Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. , 2002, Diabetes.

[52]  E. Boerwinkle,et al.  SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities Study. , 2002, Diabetes.

[53]  T. Frayling,et al.  Variation in the calpain-10 gene affects blood glucose levels in the British population. , 2002, Diabetes.

[54]  Thomas Lumley,et al.  Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension. , 2002, JAMA.

[55]  M. Igarashi,et al.  Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese. , 2002, Diabetes research and clinical practice.

[56]  David B Allison,et al.  "Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. , 2003, American journal of human genetics.

[57]  L. Cubeddu,et al.  Alpha-adducin polymorphism, salt sensitivity, nitric oxide excretion, and cardiovascular risk factors in normotensive Hispanics. , 2003, American journal of hypertension.

[58]  R. Hui,et al.  Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case–control and family-based study , 2003, Journal of hypertension.

[59]  J. Takeda,et al.  Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese. , 2003, The Journal of clinical endocrinology and metabolism.

[60]  Cristina Barlassina,et al.  ACE and &agr;-Adducin Polymorphism as Markers of Individual Response to Diuretic Therapy , 2003, Hypertension.

[61]  N E Day,et al.  The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? , 2003, International journal of epidemiology.

[62]  I. Gottesman,et al.  The endophenotype concept in psychiatry: etymology and strategic intentions. , 2003, The American journal of psychiatry.

[63]  R. Holle,et al.  Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. , 2003, American journal of human genetics.

[64]  E. Boerwinkle,et al.  Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide. , 2003, American journal of hypertension.

[65]  Alpha-Adducin Gly460Trp Polymorphism and Essential Hypertension in Korea , 2004, Journal of Korean medical science.

[66]  T. Miyata,et al.  The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. , 2004, Hypertension research : official journal of the Japanese Society of Hypertension.

[67]  Y. Kokubo,et al.  Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study. , 2004, Hypertension research : official journal of the Japanese Society of Hypertension.

[68]  E. Bel Clinical phenotypes of asthma. , 2004, Current opinion in pulmonary medicine.

[69]  Y. Kokubo,et al.  Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study. , 2004, Hypertension research : official journal of the Japanese Society of Hypertension.

[70]  J. Manson,et al.  Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies. , 2004, American journal of human genetics.

[71]  Chad Haynes,et al.  Power and sample size calculations in the presence of phenotype errors for case/control genetic association studies , 2005, BMC Genetics.

[72]  W. Spiering,et al.  &agr;-Adducin Gly460Trp Polymorphism and Renal Hemodynamics in Essential Hypertension , 2004, Hypertension.

[73]  Thomas G. Schulze,et al.  Defining the Phenotype in Human Genetic Studies: Forward Genetics and Reverse Phenotyping , 2005, Human Heredity.

[74]  J. Gulcher,et al.  The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke , 2004, Nature Genetics.

[75]  Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population , 2005, Journal of Human Genetics.

[76]  Wen-Chung Lee,et al.  Case recruitment in genetic association studies: larger sample size or greater homogeneity? , 2005, International journal of epidemiology.

[77]  G. Papanicolaou,et al.  Dissection of heterogeneous phenotypes for quantitative trait mapping , 2005, Genetic epidemiology.

[78]  Gang Zheng,et al.  The impact of diagnostic error on testing genetic association in case–control studies , 2005, Statistics in medicine.

[79]  J. Hirschhorn,et al.  Genetic association studies of complex traits: design and analysis issues. , 2005, Mutation research.

[80]  T. Hansen,et al.  Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. , 2006, Molecular genetics and metabolism.

[81]  A. Hofman,et al.  The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes , 2006, Diabetes.

[82]  N. Freimer,et al.  Endophenotypes for psychiatric disorders: ready for primetime? , 2006, Trends in genetics : TIG.

[83]  B. Stricker,et al.  Interactions between five candidate genes and antihypertensive drug therapy on blood pressure , 2006, The Pharmacogenomics Journal.

[84]  M. Winawer,et al.  Phenotype definition in epilepsy , 2006, Epilepsy & Behavior.

[85]  A. Hofman,et al.  The alpha-adducin gene is associated with macrovascular complications and mortality in patients with type 2 diabetes. , 2006, Diabetes.

[86]  W. Drevets,et al.  Toward Constructing an Endophenotype Strategy for Bipolar Disorders , 2006, Biological Psychiatry.

[87]  F. Veglio,et al.  CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly. , 2006, The Journal of clinical endocrinology and metabolism.

[88]  M. Rietschel,et al.  What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics. , 2006, Archives of general psychiatry.

[89]  P. Heutink,et al.  Genetic and clinical analysis of a large Dutch Gilles de la Tourette family , 2006, Molecular Psychiatry.

[90]  Nicholas J Schork,et al.  Methods for handling multiple testing. , 2008, Advances in genetics.