Pathological fracture prediction in patients with metastatic lesions can be improved with quantitative computed tomography based computer models.

[1]  K. Harrington.  New trends in the management of lower extremity metastases. , 1982, Clinical orthopaedics and related research.

[2]  H. Mirels.  Metastatic Disease in Long Bones A Proposed Scoring System for Diagnosing Impending Pathologic Fractures , 1989, Clinical orthopaedics and related research.

[3]  K. An,et al.  Structural consequences of transcortical holes in long bones loaded in torsion. , 1990, Journal of biomechanics.

[4]  H. Boxma,et al.  Impending and actual pathological fractures in patients with bone metastases of the long bones. A retrospective study of 233 surgically treated fractures. , 1994, The European journal of surgery = Acta chirurgica.

[5]  W. Hayes,et al.  Predicting pathologic fracture risk in the management of metastatic bone defects. , 1995, Clinical orthopaedics and related research.

[6]  G. Mundy,et al.  Mechanisms of bone metastasis , 1997, Cancer.

[7]  R. Coleman.  Skeletal complications of malignancy , 1997, Cancer.

[8]  H K Genant,et al.  Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength. , 1997, Bone.

[9]  H. Harvey.  Issues concerning the role of chemotherapy and hormonal therapy of bone metastases from breast carcinoma. , 1997, Cancer.

[10]  H. Skinner,et al.  Prediction of femoral fracture load using automated finite element modeling. , 1997, Journal of biomechanics.

[11]  S. Goldstein,et al.  Femoral strength is better predicted by finite element models than QCT and DXA. , 1999, Journal of biomechanics.

[12]  A J van den Bogert,et al.  An analysis of hip joint loading during walking, running, and skiing. , 1999, Medicine and science in sports and exercise.

[13]  E Y Chao,et al.  The open section effect in a long bone with a longitudinal defect - a theoretical modeling study. , 2000, Journal of biomechanics.

[14]  G. Bergmann,et al.  Hip contact forces and gait patterns from routine activities. , 2001, Journal of biomechanics.

[15]  Aivars Berzins,et al.  Accuracy and precision of radiostereometric analysis in the measurement of THR femoral component translations: human and canine in vitro models , 2001, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  J. Keyak.  Improved prediction of proximal femoral fracture load using nonlinear finite element models. , 2001, Medical engineering & physics.

[17]  S. Beer,et al.  Strength , 1875, Cybern. Hum. Knowing.

[18]  A. Lipton.  Bisphosphonates and metastatic breast carcinoma , 2003, Cancer.

[19]  Hwj Rik Huiskes,et al.  Trabecular Bone Tissue Strains in the Healthy and Osteoporotic Human Femur , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  J. Lok,et al.  Simple radiographic parameter predicts fracturing in metastatic femoral bone lesions: results from a randomised trial. , 2003, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[21]  Ursula Falkmer,et al.  A Systematic Overview of Radiation Therapy Effects in Skeletal Metastases , 2003, Acta oncologica.

[22]  Isao Ohnishi,et al.  Prediction of the strength and fracture location of the femoral neck by CT-based finite-element method: a preliminary study on patients with hip fracture , 2004, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.

[23]  E. Noordijk,et al.  Comparative analysis of risk factors for pathological fracture with femoral metastases. , 2004, The Journal of bone and joint surgery. British volume.

[24]  Jamshid Tehranzadeh,et al.  Predicting Proximal Femoral Strength Using Structural Engineering Models , 2005, Clinical orthopaedics and related research.

[25]  Hisatoshi Baba,et al.  Dynamic analysis of the resultant force acting on the hip joint during level walking. , 2005, Artificial organs.

[26]  G Bergmann,et al.  Determination of muscle loading at the hip joint for use in pre-clinical testing. , 2005, Journal of biomechanics.

[27]  Harrie Weinans,et al.  Prediction of torsional failure in 22 cadaver femora with and without simulated subtrochanteric metastatic defects: A CT scan-based finite element analysis , 2006, Acta orthopaedica.

[28]  B. Snyder,et al.  Predicting fracture through benign skeletal lesions with quantitative computed tomography. , 2006, The Journal of bone and joint surgery. American volume.

[29]  Taeyong Lee.  Predicting Failure Load of the Femur with Simulated Osteolytic Defects using Noninvasive Imaging Technique in a Simplified Load Case , 2007, Annals of Biomedical Engineering.

[30]  Marco Viceconti,et al.  Subject-specific finite element models of long bones: An in vitro evaluation of the overall accuracy. , 2006, Journal of biomechanics.

[31]  Nico Verdonschot,et al.  Densitometry test of bone tissue: Validation of computer simulation studies , 2008, Comput. Biol. Medicine.

[32]  B. van Rietbergen,et al.  Predictive value of femoral head heterogeneity for fracture risk. , 2009, Bone.

[33]  Z. Lidar,et al.  Surgical management of metastatic bone disease. , 2009, The Journal of bone and joint surgery. American volume.