Phosphodiesterase delta governs the mechanical properties of erythrocytes infected with Plasmodium falciparum gametocytes.

[1]  Marie-Esther N’Dri,et al.  The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Mice , 2022, Frontiers in Cellular and Infection Microbiology.

[2]  W. Moss,et al.  Functional Analysis of the Expanded Phosphodiesterase Gene Family in Toxoplasma gondii Tachyzoites , 2021, bioRxiv.

[3]  C. Lavazec,et al.  Tadalafil impacts the mechanical properties of Plasmodium falciparum gametocyte-infected erythrocytes. , 2021, Molecular and biochemical parasitology (Print).

[4]  M. Blackman,et al.  Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress , 2021, mBio.

[5]  G. Bouyer,et al.  Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability , 2020, bioRxiv.

[6]  G. Baillie,et al.  Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond , 2019, Nature Reviews Drug Discovery.

[7]  G. Nicastro,et al.  Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery , 2019, PLoS biology.

[8]  M. Blackman,et al.  Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion , 2019, PLoS biology.

[9]  A. Miele,et al.  The oligomeric assembly of the phosphodiesterase-5 is a mixture of dimers and tetramers: A putative role in the regulation of function. , 2018, Biochimica et biophysica acta. General subjects.

[10]  J. Gorelik,et al.  The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains , 2018, Journal of cardiovascular development and disease.

[11]  D. Baker,et al.  Cyclic nucleotide signalling in malaria parasites , 2017, Open Biology.

[12]  C. Lavazec.  Molecular mechanisms of deformability of Plasmodium-infected erythrocytes. , 2017, Current opinion in microbiology.

[13]  J. Scholz,et al.  Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission. , 2016, Blood.

[14]  B. Le Pioufle,et al.  Splenic Retention of Plasmodium falciparum Gametocytes To Block the Transmission of Malaria , 2015, Antimicrobial Agents and Chemotherapy.

[15]  D. Taramelli,et al.  cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission , 2015, PLoS pathogens.

[16]  A. Vaughan,et al.  Cyclic GMP Balance Is Critical for Malaria Parasite Transmission from the Mosquito to the Mammalian Host , 2015, mBio.

[17]  Esther G. L. Koh,et al.  Plasmodium vivax: restricted tropism and rapid remodeling of CD71-positive reticulocytes. , 2015, Blood.

[18]  Niseema D. Pachikara,et al.  The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes , 2014, PLoS pathogens.

[19]  K. Williamson,et al.  Plasmodium falciparum transmission stages accumulate in the human bone marrow , 2014, Science Translational Medicine.

[20]  R. Sprague,et al.  Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3′,5′ monophosphate accumulation and adenosine 3′5′ triphosphate release from human erythrocytes , 2013, Experimental biology and medicine.

[21]  M. Strath,et al.  Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress , 2013, PLoS pathogens.

[22]  C. Lim,et al.  Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum , 2012, Cellular microbiology.

[23]  R. Sauerwein,et al.  A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages. , 2012, Blood.

[24]  L. Tilley,et al.  Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes , 2012, Journal of Cell Science.

[25]  K. Williamson,et al.  Protein Targeting to the Parasitophorous Vacuole Membrane of Plasmodium falciparum , 2011, Eukaryotic Cell.

[26]  S. Kunz,et al.  The N Terminus of Phosphodiesterase TbrPDEB1 of Trypanosoma brucei Contains the Signal for Integration into the Flagellar Skeleton , 2010, Eukaryotic Cell.

[27]  Anthony A. Holder,et al.  The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony , 2009, Eukaryotic Cell.

[28]  Oliver Billker,et al.  A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite , 2009, PLoS pathogens.

[29]  A. Olivieri,et al.  The Plasmodium falciparum protein Pfg27 is dispensable for gametocyte and gamete production, but contributes to cell integrity during gametocytogenesis , 2009, Molecular microbiology.

[30]  J. Klar,et al.  Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein. , 2008, International journal for parasitology.

[31]  L. McRobert,et al.  Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase , 2008, PLoS biology.

[32]  L. McRobert,et al.  Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis , 2008, Molecular microbiology.

[33]  G. Bouyer,et al.  Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance , 2008, PLoS pathogens.

[34]  C. Lavazec,et al.  Expression switching in the stevor and Pfmc‐2TM superfamilies in Plasmodium falciparum , 2007, Molecular microbiology.

[35]  S. Kunz,et al.  A FYVE‐containing unusual cyclic nucleotide phosphodiesterase from Trypanosoma cruzi , 2005, The FEBS journal.

[36]  J. Kotera,et al.  PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum. , 2005, The Biochemical journal.

[37]  Melanie Rug,et al.  Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte , 2004, Science.

[38]  Travis Harrison,et al.  A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection , 2004, Science.

[39]  J. Beavo,et al.  Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. , 2000, Current opinion in cell biology.

[40]  R. Rosenberg,et al.  Pore size of the malaria parasite's nutrient channel. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  S. Bhakdi,et al.  Protein sorting in Plasmodium falciparum-infected red blood cells permeabilized with the pore-forming protein streptolysin O. , 1996, The Biochemical journal.

[42]  J. Corbin,et al.  Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase. , 1994, The Journal of biological chemistry.

[43]  C. Newbold,et al.  Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel. , 1994, The Journal of biological chemistry.

[44]  E. Mccleskey,et al.  A nutrient-permeable channel on the intraerythrocytic malaria parasite , 1993, Nature.

[45]  H. Ginsburg,et al.  New permeability pathways induced in membranes of Plasmodium falciparum infected erythrocytes. , 1983, Molecular and biochemical parasitology.

[46]  G. Milon,et al.  Microsphiltration: a microsphere matrix to explore erythrocyte deformability. , 2013, Methods in molecular biology.

[47]  N. Artemyev,et al.  Analysis of dimerization determinants of PDE6 catalytic subunits. , 2005, Methods in molecular biology.