Prenatal administration of vaginal progesterone and frequency of uterine contractions in asymptomatic twin pregnancies

A previous study indicated that progesterone reduces the mean uterine contraction frequency in singleton pregnancy at high risk for preterm birth. The aim of this study was to investigate the effect of vaginal progesterone on the frequency of uterine contractions in twin pregnancies.

[1]  James W. MacDonald,et al.  Uterine overdistention induces preterm labor mediated by inflammation: observations in pregnant women and nonhuman primates. , 2015, American journal of obstetrics and gynecology.

[2]  A. Liao,et al.  Vaginal progesterone for the prevention of preterm birth in twin gestations: a randomized placebo-controlled double-blind study. , 2015, American journal of obstetrics and gynecology.

[3]  K. Nicolaides,et al.  Effectiveness of progestogens to improve perinatal outcome in twin pregnancies: an individual participant data meta‐analysis , 2015, BJOG : an international journal of obstetrics and gynaecology.

[4]  S. Fisher,et al.  Preterm labor: One syndrome, many causes , 2014, Science.

[5]  V. Serra,et al.  Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double‐blind multicentre trial , 2013, BJOG : an international journal of obstetrics and gynaecology.

[6]  N. Uldbjerg,et al.  Cytokines and the Risk of Preterm Delivery in Twin Pregnancies , 2012, Obstetrics and gynecology.

[7]  K. Nicolaides,et al.  Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. , 2012, American journal of obstetrics and gynecology.

[8]  K. Nicolaides,et al.  Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo‐controlled trial on the effect of vaginal micronized progesterone , 2011, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[9]  M. Harnett,et al.  Effect of Prolonged In Vivo Administration of Progesterone in Pregnancy on Myometrial Gene Expression, Peripheral Blood Leukocyte Activation, and Circulating Steroid Hormone Levels , 2011, Reproductive Sciences.

[10]  J. Brosens,et al.  Uterine stretch and progesterone action. , 2011, The Journal of clinical endocrinology and metabolism.

[11]  M. Norusis.  IBM SPSS Statistics 19 Advanced Statistical Procedures Companion , 2011 .

[12]  Vincenzo Berghella,et al.  Twins: prevalence, problems, and preterm births. , 2010, American journal of obstetrics and gynecology.

[13]  C. Mendelson.  Minireview: fetal-maternal hormonal signaling in pregnancy and labor. , 2009, Molecular endocrinology.

[14]  Steven Thornton,et al.  Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis , 2009, The Lancet.

[15]  Elizabeth A Thom,et al.  A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. , 2007, The New England journal of medicine.

[16]  S. Dymarkowski,et al.  Placental sharing, birthweight discordance, and vascular anastomoses in monochorionic diamniotic twin placentas. , 2006, American journal of obstetrics and gynecology.

[17]  B. Sibai,et al.  A prospective masked observational study of uterine contraction frequency in twins. , 2006, American journal of obstetrics and gynecology.

[18]  J. Derks,et al.  The Natural Course of Monochorionic and Dichorionic Twin Pregnancies: A Historical Cohort , 2006, Twin Research and Human Genetics.

[19]  S. Witkin,et al.  Differential expression of immune system-related components in midtrimester amniotic fluid from singleton and twin pregnancies. , 2005, American journal of obstetrics and gynecology.

[20]  M. Dombrowski,et al.  Frequency of uterine contractions in asymptomatic pregnant women with or without a short cervix on transvaginal ultrasound scan. , 2004, American journal of obstetrics and gynecology.

[21]  M. Zugaib,et al.  Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. , 2003, American journal of obstetrics and gynecology.

[22]  A. Liao,et al.  Reference range for cervical length in twin pregnancies , 2002, Acta obstetricia et gynecologica Scandinavica.

[23]  V. Berghella,et al.  230 Most asymptomatic pregnant women with a short cervix on ultrasound are having uterine contractions , 2001 .

[24]  K. Nicolaides,et al.  Cervical length at 23 weeks of gestation: relation to demographic characteristics and previous obstetric history , 1998, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[25]  G. Saade,et al.  Control and assessment of the uterus and cervix during pregnancy and labour. , 1998, Human reproduction update.

[26]  P. Illingworth,et al.  Progesterone control of interleukin-8 production in endometrium and chorio-decidual cells underlines the role of the neutrophil in menstruation and parturition. , 1994, Human reproduction.

[27]  R. Newman,et al.  Uterine activity during pregnancy in ambulatory patients: comparison of singleton and twin gestations. , 1986, American journal of obstetrics and gynecology.

[28]  R. Newman,et al.  Correlation of antepartum uterine activity and cervical change in twin gestation. , 1997, Acta geneticae medicae et gemellologiae.

[29]  B. Parks.  The influence of fetal number on antepartum uterine activity. , 1989, Obstetrics and gynecology.