Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic.

Trichomonas vaginalis (TV) can be infected with double-stranded RNA (dsRNA) viruses that may have important implications for trichomonal virulence and disease pathogenesis. A cross-sectional study was conducted in a sexually transmitted diseases clinic to determine the prevalence and clinical significance of dsRNA viral infection of TV infecting men and women. Overall, dsRNA virus was present in 21 (75%) of 28 TV isolates (95% confidence interval [CI], 55%-89%). dsRNA viral infection of TV was not associated with the presence of discharge, dysuria, genital pruritus, or genital irritation or odor. However, patients with virus-positive isolates were significantly older than patients with virus-negative isolates (median age, 38 vs. 23 years; P=.003), and virus-positive isolates were more prevalent among women (19 [86%] of 22 isolates; 95% CI, 65%-97%) than among men (2 [33%] of 6 isolates; P=.02). The age and sex specificity of virus-positive isolates may aid in understanding the differences in chronicity and clinical presentation of TV in men and women.

[1]  R. McClelland,et al.  The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1. , 2001, The Journal of infectious diseases.

[2]  J. Douglas,et al.  Comparative Prevalence of Infection With Trichomonas vaginalis Among Men Attending a Sexually Transmitted Diseases Clinic , 2000, Sexually transmitted diseases.

[3]  W. Miller,et al.  Trichomonas vaginalis as a cause of urethritis in Malawian men. , 1999, Sexually transmitted diseases.

[4]  M. Krohn,et al.  Trichomonas vaginalis Associated With Low Birth Weight and Preterm Delivery , 1997, Sexually transmitted diseases.

[5]  J. Krieger Trichomoniasis in Men: Old Issues and New Data , 1995, Sexually transmitted diseases.

[6]  J. Alderete,et al.  Two Trichomonas vaginalis surface proteinases bind to host epithelial cells and are related to levels of cytoadherence and cytotoxicity. , 1995, Archives of medical research.

[7]  J. Alderete,et al.  Trichomonas vaginalis with a double-stranded RNA virus has upregulated levels of phenotypically variable immunogen mRNA , 1994, Journal of virology.

[8]  K. Holmes,et al.  Clinical Manifestations of Trichomoniasis in Men , 1993, Annals of Internal Medicine.

[9]  P. Piot,et al.  Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. , 1993 .

[10]  D. Campbell Diagnosis of trichomoniasis. Comparison of conventional wet-mount examination with cytologic studies, cultures, and monoclonal antibody staining of direct specimens , 1988 .

[11]  K. Holmes,et al.  Diagnosis of trichomoniasis. Comparison of conventional wet-mount examination with cytologic studies, cultures, and monoclonal antibody staining of direct specimens. , 1988, JAMA.

[12]  C. Wang,et al.  Trichomonas vaginalis phenotypic variation occurs only among trichomonads infected with the double-stranded RNA virus , 1987, The Journal of experimental medicine.

[13]  J. Feldman,et al.  Risk factors for prematurity and premature rupture of membranes: a prospective study of the vaginal flora in pregnancy. , 1984, American journal of obstetrics and gynecology.

[14]  P. Hardy,et al.  PREVALENCE OF SIX SEXUALLY TRANSMITTED DISEASE AGENTS AMONG PREGNANT INNER-CITY ADOLESCENTS AND PREGNANCY OUTCOME , 1984, The Lancet.

[15]  L. S. Diamond Techniques of axenic cultivation of Entamoeba histolytica Schaudinn, 1903 and E. histolytica-like amebae. , 1968, The Journal of parasitology.