Monitoring biomedical motion and flow by means of coherent light fluctuations

Laser light, when scattered from a moving object or fluid, fluctuates in intensity. These fluctuations can yield information about the velocity of the scatterers involved. Two approaches have been used over the past twenty years or so. The techniques of photon correlation spectroscopy and laser Doppler effectively measure the frequency shift that occurs when light is scattered from moving objects. Regarding the phenomenon as a time-varying speckle pattern, however, opens up several other measurement possibilities. This review paper describes some recent biomedical applications of these techniques.

[1]  M. Stern,et al.  Laser Doppler velocimetry in blood and multiply scattering fluids: theory. , 1985, Applied optics.

[2]  G. Tribillon,et al.  Biological Activity Measurement on Botanical Specimen Surfaces Using a Temporal Decorrelation Effect of Laser Speckle , 1989 .

[3]  A. F. Fercher,et al.  Velocity measurement by first order statistics of time-differentiated laser speckles , 1980 .

[4]  Toyoichi Tanaka,et al.  Blood Velocity Measurements in Human Retinal Vessels , 1974, Science.

[5]  J. David Briers.  Laser speckle techniques in biology and medicine , 1994, Other Conferences.

[6]  J. D. Briers,et al.  Holographic, speckle and moiré techniques in optical metrology , 1993 .

[7]  J. Briers.  The Measurement of Plant Elongation Rates by Means of Holographic Interferometry: Possibilities and Limitations , 1977 .

[8]  H Fujii,et al.  Blood flow observed by time-varying laser speckle. , 1985, Optics letters.

[9]  V. Twersky.  Absorption and multiple scattering by biological suspensions. , 1970, Journal of the Optical Society of America.

[10]  M. Stern,et al.  In vivo evaluation of microcirculation by coherent light scattering , 1975, Nature.

[11]  C S Ih,et al.  Feature information extraction from dynamic biospeckle. , 1994, Applied optics.

[12]  J. D. Briers,et al.  Wavelength dependence of intensity fluctuations in laser speckle patterns from biological specimens , 1975 .

[13]  Evaluation of Skin Blood Flow Using Laser Speckle Phenomena (II) , 1984 .

[14]  Toshimitsu Asakura,et al.  Velocity measurement of the diffuse object based on time-differentiated speckle intensity fluctuations , 1979 .

[15]  Charles Joenathan,et al.  Temporal and spatial properties of the time-varying speckles of botanical specimens , 1995 .

[16]  Benno L. Petrig,et al.  Scattering process in LDV from retinal vessels. , 1989, Applied optics.

[17]  E. R. Pike,et al.  Laser Doppler anemometry , 1974 .

[18]  L. Allen,et al.  An analysis of the granularity of scattered optical maser light , 1963 .

[19]  E. Ingelstam,et al.  Eye refraction examined by aid of speckle pattern produced by coherent light. , 1972, Vision research.

[20]  Richard P. C. Johnson.  Laser Doppler Microscopy: Especially as a Method for Studying Brownian Motion and Flow in the Sieve Tubes of Plants , 1983 .