Polyimide-polyethylene glycol block copolymers: synthesis, characterization, and initial evaluation as a biomaterial.

Block copolyimides with varying amounts of polyethylene glycol (PEG) were synthesized and characterized by copolymerization of diaminodiphenyl ether (DDE), amino terminated PEG, and benzophenone tetracarboxylic acid dianhydride (BTDA). Strong materials were obtained, with enhanced flexibility as compared to the parent DDE-BTDA polyimide homopolymer. Incorporation of PEG led to an increase in water absorption by these copolymers, and hydrophilicity was increased as reflected by a decrease in air-water-polymer contact angle. These materials supported less cell adhesion in vitro than the parent polyimide homopolymer. Short term in vivo evaluation of these copolymers showed reduced fibrous encapsulation than was observed in the absence of PEG.

[1]  Xuehai Yu,et al.  Polyether–polyimide thermoplastic elastomers. I. Synthesis and properties , 1992 .

[2]  A. Takahara,et al.  Surface Properties and Platelet Reactivity of Segmented Poly(etherurethanes) and Poly(etherurethaneureas) , 1991, Journal of biomaterials applications.

[3]  I. Hinberg,et al.  In vitro degradation of a poly(ether urethane) by trypsin. , 1991, Journal of biomedical materials research.

[4]  J. Hubbell,et al.  Solution technique to incorporate polyethylene oxide and other water-soluble polymers into surfaces of polymeric biomaterials. , 1991, Biomaterials.

[5]  J M Anderson,et al.  Foreign-body giant cells and polyurethane biostability: in vivo correlation of cell adhesion and surface cracking. , 1991, Journal of biomedical materials research.

[6]  C. Batich,et al.  Toxic hydrolysis product from a biodegradable foam implant. , 1989, Journal of biomedical materials research.

[7]  Wang Guanghui,et al.  Immobilization of poly(ethylene oxide) on poly(ethylene terephthalate) using a plasma polymerization process , 1989 .

[8]  B. Ratner,et al.  Analysis of in vitro enzymatic and oxidative degradation of polyurethanes. , 1988, Journal of biomedical materials research.

[9]  A. Hiltner,et al.  Long term biodegradation in vitro of poly(ether urethane urea): a mechanical property study , 1987 .

[10]  K. Mukai,et al.  Planar multilevel interconnection technology employing a polyimide , 1978 .

[11]  C. S. Schollenberger,et al.  Thermoplastic Polyurethane Hydrolysis Stability , 1971 .

[12]  J. Dillon,et al.  Degradation of five polyurethane gastric bubbles following in vivo use: SEC, ATR-IR and DSC studies. , 1992, Biomaterials.

[13]  J. Hubbell,et al.  Tissue response to intraperitoneal implants of polyethylene oxide-modified polyethylene terephthalate. , 1992, Biomaterials.

[14]  J. A. Hubbell,et al.  Poly(ethylene oxide)-graft-poly(L-lysine) copolymers to enhance the biocompatibility of poly(L-lysine)-alginate microcapsule membranes. , 1992, Biomaterials.

[15]  S. Cooper,et al.  Bulk, surface, and blood-contacting properties of polyetherurethanes modified with polyethylene oxide. , 1989, Journal of biomaterials science. Polymer edition.

[16]  Y. Ito,et al.  Synthesis and non-thrombogenicity of polyurethanes with poly(oxyethylene) side chains in soft segment regions. , 1989, Journal of biomaterials science. Polymer edition.

[17]  H. S. Lusted,et al.  Histological reaction to polyimide films in the cochlea. , 1989, Acta oto-laryngologica.

[18]  A. Horwitz,et al.  Cell surface receptors for extracellular matrix molecules. , 1987, Annual review of cell biology.