In vivo quantification of propylene glycol, glucose and glycerol diffusion in human skin with optical coherence tomography

The purpose of study is to quantify and compare diffusion of propylene glycol, glucose, glycerol in the human skin in vivo noninvasively. Optical coherence tomography (OCT) was utilized in the functional imaging of optical cleaning agents for monitoring and quantifying the permeability coefficients (PCs) of them. Our experiments showed that the permeability coefficient of 40% propylene glycol from different subjects was averaged and found to be (2.52 ± 0.02) × 10−6 cm/s, the permeability coefficient of 40% glucose was (1.94 ± 0.05) × 10−6 cm/s, and the permeability coefficient of 40% glycerol was (1.82 ± 0.04) × 10−6 cm/s. The results indicated that the diffusion of propylene glycol solutions was faster than that of glucose solution, and the diffusion of glucose solutions was faster than that of glycerol solutions. The dependence of the permeability on the different hyperosmotic analytes could potentially be used in various basic science and clinical fields, such as optical clearing of tissues and cells as well as in clinical pharmacology.

[1]  Huajiang Wei,et al.  Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography , 2010 .

[2]  Valery V Tuchin,et al.  Nondestructive quantification of analyte diffusion in cornea and sclera using optical coherence tomography. , 2007, Investigative ophthalmology & visual science.

[3]  Mohamad G. Ghosn,et al.  Nonlinear diffusivity of analytes in tissues , 2008, SPIE BiOS.

[4]  Andrew K. Dunn,et al.  Three-dimensional computation of light scattering from cells , 1996 .

[5]  Ruikang K. Wang,et al.  Penetration kinetics of dimethyl sulphoxide and glycerol in dynamic optical clearing of porcine skin tissue in vitro studied by Fourier transform infrared spectroscopic imaging. , 2008, Journal of biomedical optics.

[6]  Valentin M. Gelikonov,et al.  Broadband digital holographic technique of optical coherence tomography for 3-dimensional biotissue visualization , 2009 .

[7]  Zhouyi Guo,et al.  Quantitative analysis on tongue inspection in traditional Chinese medicine using optical coherence tomography. , 2008, Journal of biomedical optics.

[8]  R. Kuranov,et al.  In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography. , 2006, Physics in medicine and biology.

[9]  Adrian Glasser,et al.  Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography , 2009, Journal of biophotonics.

[10]  Massoud Motamedi,et al.  Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: a pilot study. , 2003, Physics in medicine and biology.

[11]  Mohamad G. Ghosn,et al.  Depth-resolved monitoring of analytes diffusion in ocular tissues , 2007, SPIE BiOS.

[12]  A J Welch,et al.  Using sandpaper for noninvasive transepidermal optical skin clearing agent delivery. , 2006, Journal of biomedical optics.

[13]  John V Frangioni,et al.  Optical clearing of the skin for near-infrared fluorescence image-guided surgery. , 2009, Journal of biomedical optics.

[14]  A. Gomes,et al.  Determination of dental decay rates with optical coherence tomography , 2009 .

[15]  Valery V. Tuchin,et al.  Optical clearing of tissues and blood using the immersion method , 2005 .

[16]  Valery V. Tuchin,et al.  Functional imaging and assessment of the glucose diffusion rate in epithelial tissues in optical coherence tomography , 2008 .

[17]  Ruikang K. Wang,et al.  Improvement of low-level light imaging performance using optical clearing method. , 2004, Biosensors & bioelectronics.

[18]  V V Tuchin,et al.  Optical clearing of skin using flashlamp‐induced enhancement of epidermal permeability , 2006, Lasers in surgery and medicine.

[19]  Bernard Choi,et al.  Correlation between collagen solubility and skin optical clearing using sugars , 2007, Lasers in surgery and medicine.

[20]  Bernard Choi,et al.  Determination of chemical agent optical clearing potential using in vitro human skin , 2005, Lasers in surgery and medicine.

[21]  Valery V Tuchin,et al.  Glucose and mannitol diffusion in human dura mater. , 2003, Biophysical journal.

[22]  P. So,et al.  Confocal microscopy and multi-photon excitation microscopy of human skin in vivo. , 2001, Optics express.

[23]  Valery V. Tuchin,et al.  Enhanced OCT imaging of embryonic tissue with optical clearing , 2008 .

[24]  Valery V. Tuchin,et al.  Possible mechanisms for optical clearing of whole blood by dextrans , 2003, SPIE BiOS.

[25]  Dan Zhu,et al.  Influence of alcohols on the optical clearing effect of skin in vitro. , 2008, Journal of biomedical optics.

[26]  Valery V Tuchin,et al.  Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera. , 2008, Journal of biomedical optics.

[27]  Adam Boretsky,et al.  Dermal scatter reduction in human skin: A method using controlled application of glycerol , 2009, Lasers in surgery and medicine.

[28]  Xiangqun Xu,et al.  Assessment of the effects of ultrasound-mediated alcohols on skin optical clearing. , 2009, Journal of biomedical optics.

[29]  Sergey G. Proskurin,et al.  Optical coherence tomography imaging depth enhancement by superficial skin optical clearing , 2007 .

[30]  I. Meglinski,et al.  Plant photonics: application of optical coherence tomography to monitor defects and rots in onion , 2010 .

[31]  M. Coroneo,et al.  In vivo confocal microscopy of the human cornea , 2003, The British journal of ophthalmology.

[32]  V. Tuchin.  Optical immersion as a new tool for controlling the optical properties of tissues and blood , 2005 .

[33]  Ruikang K. Wang,et al.  Dynamic optical clearing effect of tissue impregnated with hyperosmotic agents and studied with optical coherence tomography. , 2004, Journal of biomedical optics.

[34]  Huajiang Wei,et al.  Enhancement of permeability of glycerol with ultrasound in human normal and cancer breast tissues in vitro using optical coherence tomography , 2010 .

[35]  Kirill V Larin,et al.  Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues. , 2008, Journal of biomedical optics.

[36]  J. Lademann,et al.  Application of optical non-invasive methods in skin physiology , 2008 .

[37]  V. Gelikonov,et al.  Optical method for the screening of doping substances , 2008 .

[38]  Bernard Choi,et al.  Optical clearing of in vivo human skin: Implications for light‐based diagnostic imaging and therapeutics , 2004, Lasers in surgery and medicine.

[39]  Christopher G. Rylander,et al.  Mechanical tissue optical clearing devices: Enhancement of light penetration in ex vivo porcine skin and adipose tissue , 2008, Lasers in surgery and medicine.

[40]  Igor Meglinski,et al.  Application of wavelet analysis in optical coherence tomography for obscured pattern recognition , 2009 .

[41]  A J Welch,et al.  Enhancement of transepidermal skin clearing agent delivery using a 980 nm diode laser , 2005, Lasers in surgery and medicine.

[42]  Massoud Motamedi,et al.  Temporary dermal scatter reduction: Quantitative assessment and implications for improved laser tattoo removal , 2005, Lasers in surgery and medicine.

[43]  V V Tuchin,et al.  Light propagation in tissues with controlled optical properties , 1996, European Conference on Biomedical Optics.

[44]  Qingming Luo,et al.  Short-term and long-term effects of optical clearing agents on blood vessels in chick chorioallantoic membrane. , 2008, Journal of biomedical optics.

[45]  Xiangqun Xu,et al.  Feasibility of Sonophoretic Delivery for Effective Skin Optical Clearing , 2008, IEEE Transactions on Biomedical Engineering.

[46]  R. Samad,et al.  Determination of ablation threshold for composite resins and amalgam irradiated with femtosecond laser pulses , 2010 .

[47]  Juan Zhai,et al.  Using low-frequency ultrasound to improve the optical clearing of porcine skin , 2008, Photonics and Optoelectronics Meetings.

[48]  W. Briels,et al.  Modulating the skin barrier function by DMSO : molecular dynamics simulations of hydrophilic and hydrophobic transmembrane pores , 2008 .

[49]  R. Esenaliev,et al.  Noninvasive blood glucose monitoring with optical coherence tomography: a pilot study in human subjects. , 2002, Diabetes care.

[50]  Kirill V. Larin,et al.  Quantification of glucose diffusion in arterial tissues by using optical coherence tomography , 2007 .

[51]  Dan Zhu,et al.  In vivo skin optical clearing by glycerol solutions: mechanism , 2009, Journal of biophotonics.

[52]  Xiangqun Xu,et al.  Evaluation of skin optical clearing enhancement with Azone as a penetration enhancer , 2007 .

[53]  Vasilis Ntziachristos,et al.  Small-animal optical imaging. , 2008, Journal of biomedical optics.

[54]  Bernard Choi,et al.  Enhancement of optical skin clearing efficacy using a microneedle roller. , 2008, Journal of biomedical optics.

[55]  Duco Jansen,et al.  Use of glycerol as an optical clearing agent for enhancing photonic transference and detection of Salmonella typhimurium through porcine skin. , 2006, Journal of biomedical optics.

[56]  Igor Meglinski,et al.  Application of optical coherence tomography for imaging of scaffold structure and micro-flows characterization , 2008 .

[57]  Valery V. Tuchin,et al.  Concentration effect on the diffusion of glucose in ocular tissues , 2008 .