Dopamine and preparatory behavior: II. A neurochemical analysis.

: Changes in the activity of dopamine-containing systems in relation to preparatory and consummatory feeding responses were investigated. In Experiment 1 rats were conditioned to associate food delivery with the presentation of a conditional stimulus (CS+). When sacrificed after exposure to the CS+ alone on a test trial, the ratio of the dopamine metabolite 3,4-dihydroxyphenylacetic acid to dopamine (DOPAC/DA ratio) was increased significantly in the nucleus accumbens. A similar trend in the ratio of homovanillic acid to dopamine (HVA/DA ratio) was also observed. Similar increases were observed in the striatum, but these were not statistically significant. In contrast, no increases were observed in the DOPAC/DA ratio or the HVA/DA ratio in either brain region when rats were permitted to consume an unsignaled meal for 7 min. These findings suggest that activation of dopamine terminals in the nucleus accumbens occurs during the anticipation of a meal, at which times the rat is engaged in preparatory feeding behaviors, but does not accompany the performance of short bouts of consummatory feeding behavior.

[1]  C. Sherrington.  Integrative Action of the Nervous System , 1907 .

[2]  William Rowan,et al.  The Study of Instinct , 1953 .

[3]  N. Tinbergen,et al.  The Study of Instinct , 1953 .

[4]  T. Sourkes,et al.  Homovanillic acid and dihydroxyphenylacetic acid in the striatum of monkeys with brain lesions. , 1967, Canadian journal of physiology and pharmacology.

[5]  J. Konorski.  Integrative activity of the brain , 1967 .

[6]  B. Żernicki.  Reflex as the unit of neuro-behavioral activity: a theoretical multidisciplinary approach to the reflex activity in higher animals. , 1968, Acta biologiae experimentalis.

[7]  D. Bindra.  Neuropsychological interpretation of the effects of drive and incentive-motivation on general activity and instrumental behavior. , 1968 .

[8]  I. Eibl-Eibesfeldt.  Ethology, the biology of behavior , 1970 .

[9]  M. H. Aprison.  Advances in biochemical psychopharmacology: Volume 1, edited by E. Costa and P. Greengard, Raven press (1969) , 1970 .

[10]  E. Domino.  Amphetamines and related compounds : E. Costa and S. Garattini (Editors.) (Raven Press, New York, 1970, 962 p. $ 28.50) , 1971 .

[11]  R. Bolles.  Reinforcement, expectancy, and learning. , 1972 .

[12]  T. Crow,et al.  Catecholamine-containing neurones and electrical self-stimulation: 2. A theoretical interpretation and some psychiatric implications , 1973, Psychological Medicine.

[13]  P. Teitelbaum,et al.  Nigrostriatal bundle damage and the lateral hypothalamic syndrome. , 1974, Journal of comparative and physiological psychology.

[14]  F. G. Worden,et al.  The neurosciences : third study program , 1974 .

[15]  B. Weiss,et al.  Behavioral pharmacology : the current status , 1975 .

[16]  Joseph F. Williams.  Annual Review of Pharmacology , 1975 .

[17]  B. Migler.  Conditioned approach: An analogue of conditioned avoidance; Effects of chlorpromazine and diazepam , 1975, Pharmacology Biochemistry and Behavior.

[18]  J. Korf,et al.  Turnover of acid dopamine metabolites in striatal and mesolimbic tissue of the rat brain. , 1976, European journal of pharmacology.

[19]  M. Zigmond,et al.  Effects of dopaminergic agonists and antagonists of feeding in intact and 6-hydroxydopamine-treated rats. , 1977, The Journal of pharmacology and experimental therapeutics.

[20]  J. Blundell,et al.  Pharmacological manipulation of hoarding: Further analysis of amphetamine isomers and pimozide , 1977 .

[21]  Changes in dopamine metabolism associated with fasting and satiation. , 1977, Advances in biochemical psychopharmacology.

[22]  M. Le Moal,et al.  Behavioral effects of a lesion in the ventral mesencephalic tegmentum: evidence for involvement of A10 dopaminergic neurons. , 1977, Advances in biochemical psychopharmacology.

[23]  Anthony G. Phillips,et al.  Decreased resistance to extinction after haloperidol: Implications for the role of dopamine in reinforcement , 1979, Pharmacology Biochemistry and Behavior.

[24]  J. Korf,et al.  TURNOVER OF FREE AND CONJUGATED (SULPHONYLOXY) DIHYDROXYPHENYLACETIC ACID AND HOMOVANILLIC ACID IN RAT STRIATUM , 1979, Journal of neurochemistry.

[25]  A. Lowe.  The neural regulation of tongue movements , 1980, Progress in Neurobiology.

[26]  T. Heffner,et al.  Feeding increases dopamine metabolism in the rat brain. , 1980, Science.

[27]  A. Sclafani,et al.  The effects of pimozide on the consumption of a palatable saccharin-glucose solution in the rat , 1981, Pharmacology Biochemistry and Behavior.

[28]  A. Phillips,et al.  Disruption of autoshaped responding to a signal of brain-stimulation reward by neuroleptic drugs , 1981, Pharmacology Biochemistry and Behavior.

[29]  F. Toates.  The Control of Ingestive Behaviour by Internal and External Stimuli—A Theoretical Review , 1981, Appetite.

[30]  N. Lobaugh,et al.  Tactile extinction: Distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage , 1982, Pharmacology Biochemistry and Behavior.

[31]  T. Schallert,et al.  Cholecystokinin-octapeptide effects on eating elicited by “external” versus “internal” cues in rats , 1982, Appetite.

[32]  R. Dantzer,et al.  Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat. , 1982, Life sciences.

[33]  B. Westerink,et al.  Estimation of the Turnover of 3‐Methoxytyramine in the Rat Striatum by HPLC with Electrochemical Detection: Implications for the Sequence in the Cerebral Metabolism of Dopamine , 1982, Journal of neurochemistry.

[34]  Jaak Panksepp,et al.  Toward a general psychobiological theory of emotions , 1982, Behavioral and Brain Sciences.

[35]  S. Schiff.  Conditioned dopaminergic activity. , 1982, Biological psychiatry.

[36]  R. Roth,et al.  Pharmacology of mesocortical dopamine neurons. , 1983, Pharmacological reviews.

[37]  H. de Wit,et al.  Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. , 1984, Psychological review.

[38]  H. Weingarten.  Meal initiation controlled by learned cues: Basic behavioral properties , 1984, Appetite.

[39]  K. Ishii,et al.  Voltammetry in unanesthetized rat: Increases of striatal dopamine turnover after unilateral haloperidol injection into the substantia nigra , 1984, Neuroscience Letters.

[40]  T. Heffner,et al.  Time-dependent changes in hypothalamic dopamine metabolism during feeding in the rat , 1984, Pharmacology Biochemistry and Behavior.

[41]  Trigeminal reflexes and ingestive behavior in the rat. , 1984 .

[42]  T. Heffner,et al.  Increased transport of 3,4-dihydroxyphenylacetic acid from brain during performance of operant behavior in the rat , 1984, Brain Research.

[43]  N. Geary,et al.  Pimozide decreases the positive reinforcing effect of sham fed sucrose in the rat , 1985, Pharmacology Biochemistry and Behavior.

[44]  A. Kelley,et al.  Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with L-dopa. , 1985, Behavioral Neuroscience.

[45]  J. Commissiong.  Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity. , 1985, Biochemical pharmacology.

[46]  Gerard P. Smith,et al.  Food-related stimuli increase the ratio of 3,4-dihydroxyphenylacetic acid to dopamine in the hypothalamus , 1985, Pharmacology Biochemistry and Behavior.

[47]  H. Weingarten.  Stimulus control of eating: Implications for a two-factor theory of hunger , 1985, Appetite.

[48]  Pharmacological manipulations of the nucleus accumbens: effects on classically conditioned responses and locomotor activity in the cat. , 1985 .

[49]  A. Phillips,et al.  Increased dopamine metabolism in the nucleus accumbens and striatum following consumption of a nutritive meal but not a palatable non-nutritive saccharin solution , 1986, Pharmacology Biochemistry and Behavior.

[50]  N. White.  Control of sensorimotor function by dopaminergic nigrostriatal neurons: Influence on eating and drinking , 1986, Neuroscience & Biobehavioral Reviews.

[51]  W. Schultz.  Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey. , 1986, Journal of neurophysiology.

[52]  H. Fibiger,et al.  Factors affecting the stability and separation of biogenic amines and their metabolites. Simultaneous measurement by HPLC with electrochemical detection. , 1987, Journal of pharmacological methods.

[53]  G. P. Smith,et al.  Sham feeding of sucrose increases the ratio of 3,4-dihydroxyphenylacetic acid to dopamine in the hypothalamus , 1987, Pharmacology Biochemistry and Behavior.

[54]  A. Phillips,et al.  Dopamine and preparatory behavior: I. Effects of pimozide. , 1987, Behavioral neuroscience.

[55]  J. Engel,et al.  Brain Reward Systems and Abuse , 1987 .