α-Synuclein Affects the MAPK Pathway and Accelerates Cell Death*
暂无分享,去创建一个
I. Kanazawa | N. Nukina | A. Iwata | I Kanazawa | M Maruyama | N Nukina | M. Maruyama | A Iwata | I. Kanazawa | Mieko Maruyama
[1] B. Giasson,et al. Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. , 2000, The Journal of biological chemistry.
[2] L. Mahadevan,et al. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun , 1994, Molecular and cellular biology.
[3] J. Trojanowski,et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. , 2000, Science.
[4] Sid Gilman,et al. Widespread Alterations of α-Synuclein in Multiple System Atrophy , 1999 .
[5] H. K. Sluss,et al. Selective interaction of JNK protein kinase isoforms with transcription factors. , 1996, The EMBO journal.
[6] A. Brunet,et al. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). , 1994, The EMBO journal.
[7] W. Schiemann,et al. Involvement of protein kinase C during activation of the mitogen-activated protein kinase cascade by leukemia inhibitory factor. Evidence for participation of multiple signaling pathways. , 1994, The Journal of biological chemistry.
[8] Nigel J. Cairns,et al. Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies , 1998, Neuroscience Letters.
[9] F. Hobbs,et al. Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase* , 1998, The Journal of Biological Chemistry.
[10] J. Schwartz,et al. Growth Hormone Stimulates Phosphorylation and Activation of Elk-1 and Expression of c-fos, egr-1, andjunB through Activation of Extracellular Signal-regulated Kinases 1 and 2* , 1998, The Journal of Biological Chemistry.
[11] Jiahuai Han,et al. Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6) (*) , 1996, The Journal of Biological Chemistry.
[12] MoonHee Lee,et al. Effect of the overexpression of wild‐type or mutant α‐synuclein on cell susceptibility to insult , 2001 .
[13] J Kim,et al. Copper(II)-induced self-oligomerization of alpha-synuclein. , 1999, The Biochemical journal.
[14] R. Alexander,et al. p38 Mitogen-activated Protein Kinase Is a Critical Component of the Redox-sensitive Signaling Pathways Activated by Angiotensin II , 1998, The Journal of Biological Chemistry.
[15] J. Trojanowski,et al. Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. , 2000, The American journal of pathology.
[16] R. Scheller,et al. Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[17] Olaf Riess,et al. AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease , 1998, Nature Genetics.
[18] Heidi Phillips,et al. Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.
[19] L. Meijer,et al. Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein* , 2000, The Journal of Biological Chemistry.
[20] M. Diaz-Meco,et al. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. , 1995, The EMBO journal.
[21] Jiahuai Han,et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms , 1995, Science.
[22] A. Clerk,et al. Stimulation of “Stress-regulated” Mitogen-activated Protein Kinases (Stress-activated Protein Kinases/c-Jun N-terminal Kinases and p38-Mitogen-activated Protein Kinases) in Perfused Rat Hearts by Oxidative and Other Stresses* , 1998, The Journal of Biological Chemistry.
[23] Ichiro Kanazawa,et al. alpha-Synuclein forms a complex with transcription factor Elk-1. , 2001 .
[24] D. Stumpo,et al. Protein kinase C-dependent and -independent pathways of proto-oncogene induction in human astrocytoma cells. , 1987, The Journal of biological chemistry.
[25] M. Lisanti,et al. Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr(14)) via activation of p38 mitogen-activated protein kinase and c-Src kinase. Evidence for caveolae, the actin cytoskeleton, and focal adhesions as mechanical sensors of osmotic stress. , 2001, The Journal of biological chemistry.
[26] D. Dickson,et al. Multiple System Atrophy: A Sporadic Synucleinopathy , 1999, Brain pathology.
[27] P. Cohen,et al. The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells. , 1995, The Biochemical journal.
[28] J. Benovic,et al. Synucleins Are a Novel Class of Substrates for G Protein-coupled Receptor Kinases* , 2000, The Journal of Biological Chemistry.
[29] T. Mosmann. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.
[30] K. Fukunaga,et al. Dephosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin by Calcineurin , 1985, Journal of neurochemistry.
[31] M. Ishizawa,et al. Simple procedure of DNA isolation from human serum. , 1991, Nucleic acids research.
[32] L. Zon,et al. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun , 1994, Nature.
[33] J. Trojanowski,et al. Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro * , 1999, The Journal of Biological Chemistry.
[34] J. Woodgett,et al. The stress-activated protein kinase subfamily of c-Jun kinases , 1994, Nature.
[35] A. Goldberg,et al. Cellular Defenses against Unfolded Proteins A Cell Biologist Thinks about Neurodegenerative Diseases , 2001, Neuron.
[36] S. Nakashima,et al. Possible Involvement of Mitogen‐Activated Protein Kinase in Phospholipase D Activation Induced by H2O2, but Not by Carbachol, in Rat Pheochromocytoma PC12 Cells , 1998, Journal of neurochemistry.
[37] S. Parsons,et al. Roles for Protein Kinase C and Mitogen‐Activated Protein Kinase in Nicotine‐Induced Secretion from Bovine Adrenal Chromaffin Cells , 1997, Journal of neurochemistry.
[38] M. Karin,et al. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. , 1993, Genes & development.
[39] J Q Trojanowski,et al. Synucleinopathies: clinical and pathological implications. , 2001, Archives of neurology.
[40] Jerry L. Adams,et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis , 1994, Nature.
[41] Tetsuya Takahashi,et al. Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. , 2001, Biochemical and biophysical research communications.
[42] C. Slaughter,et al. ERK phosphorylation potentiates Elk‐1‐mediated ternary complex formation and transactivation. , 1995, The EMBO journal.
[43] Robert L. Nussbaum,et al. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .
[44] N. Wilkie,et al. Stimulated Mitogen-activated Protein Kinase Is Necessary but Not Sufficient for the Mitogenic Response to Angiotensin II , 1996, The Journal of Biological Chemistry.
[45] Richard Treisman,et al. Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity , 1995, Cell.
[46] J Q Trojanowski,et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein , 1998, Annals of neurology.
[47] C. Crews,et al. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. , 1992, Science.
[48] A. Morris,et al. Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. , 1998, Biochemistry.
[49] John Hardy,et al. The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity , 2000, The Journal of Neuroscience.
[50] M. Karin,et al. Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)* , 1999, The Journal of Biological Chemistry.
[51] E. Masliah,et al. Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro , 1999 .
[52] Y. Yang,et al. Enhanced vulnerability to oxidative stress by α-synuclein mutations and C-terminal truncation , 2000, Neuroscience.
[53] W. Bender,et al. A Drosophila model of Parkinson's disease , 2000, Nature.
[54] M. Citron,et al. Both Familial Parkinson’s Disease Mutations Accelerate α-Synuclein Aggregation* , 1999, The Journal of Biological Chemistry.
[55] J Q Trojanowski,et al. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. , 1998, The American journal of pathology.
[56] E. Masliah,et al. α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress , 2000 .
[57] J. Kimura,et al. Cyclin-dependent Kinase 5 and Mitogen-activated Protein Kinase in Glial Cytoplasmic Inclusions in Multiple System Atrophy , 1998, Journal of neuropathology and experimental neurology.
[58] M. Linial,et al. Involvement of extracellular signal-regulated kinase (ERK) in pardaxin-induced dopamine release from PC12 cells. , 2001, The Journal of pharmacology and experimental therapeutics.
[59] F. McCormick,et al. Reconstitution of the Raf-1—MEK—ERK Signal Transduction Pathway In Vitro , 1993, Molecular and cellular biology.
[60] M. Karin,et al. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain , 1994, Cell.
[61] L. Petrucelli,et al. α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins , 1999, The Journal of Neuroscience.
[62] E. Masliah,et al. Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease* , 1999, The Journal of Biological Chemistry.
[63] J Q Trojanowski,et al. A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly* , 2001, The Journal of Biological Chemistry.
[64] R. Nussbaum,et al. α-Synuclein Is Phosphorylated by Members of the Src Family of Protein-tyrosine Kinases* , 2001, The Journal of Biological Chemistry.
[65] M. L. Schmidt,et al. α-Synuclein in Lewy bodies , 1997, Nature.
[66] L. Mucke,et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. , 2000, Science.